Search Results - "Hamilton, Nicholas A"

Anillin Promotes Cell Contractility by Cyclic Resetting of RhoA Residence Kinetics by Budnar, Srikanth, Husain, Kabir B., Gomez, Guillermo A., Naghibosadat, Maedeh, Varma, Amrita, Verma, Suzie, Hamilton, Nicholas A., Morris, Richard G., Yap, Alpha S.

“…RhoA stimulates cell contractility by recruiting downstream effectors to the cortical plasma membrane. We now show that direct binding by anillin is required…”
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Global Quantification of Tissue Dynamics in the Developing Mouse Kidney by Short, Kieran M., Combes, Alexander N., Lefevre, James, Ju, Adler L., Georgas, Kylie M., Lamberton, Timothy, Cairncross, Oliver, Rumballe, Bree A., McMahon, Andrew P., Hamilton, Nicholas A., Smyth, Ian M., Little, Melissa H.

“…Although kidneys of equal size can vary 10-fold in nephron number at birth, discovering what regulates such variation has been hampered by a lack of…”
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The Vps35 D620N Mutation Linked to Parkinson's Disease Disrupts the Cargo Sorting Function of Retromer by Follett, Jordan, Norwood, Suzanne J., Hamilton, Nicholas A., Mohan, Megha, Kovtun, Oleksiy, Tay, Stephanie, Zhe, Yang, Wood, Stephen A., Mellick, George D., Silburn, Peter A., Collins, Brett M., Bugarcic, Andrea, Teasdale, Rohan D.

“…A genetic mutation in the Vps35 subunit of retromer has recently been linked to late onset Parkinson's disease. We observed that the distribution and…”
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Nephron progenitor commitment is a stochastic process influenced by cell migration by Lawlor, Kynan T, Zappia, Luke, Lefevre, James, Park, Joo-Seop, Hamilton, Nicholas A, Oshlack, Alicia, Little, Melissa H, Combes, Alexander N

“…Progenitor self-renewal and differentiation is often regulated by spatially restricted cues within a tissue microenvironment. Here, we examine how progenitor…”
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N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway by Yap, Alpha S, Kovacs, Eva M, Verma, Suzie, Ali, Radiya G, Ratheesh, Aparna, Hamilton, Nicholas A, Akhmanova, Anna

“…N-WASP activates Arp2/3-mediated actin nucleation. N-WASP is now shown to stabilize and organize the actin cytoskeleton at cell–cell junctions through its…”
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LLAMA: a robust and scalable machine learning pipeline for analysis of large scale 4D microscopy data: analysis of cell ruffles and filopodia by Lefevre, James G, Koh, Yvette W. H, Wall, Adam A, Condon, Nicholas D, Stow, Jennifer L, Hamilton, Nicholas A

“…Abstract Background With recent advances in microscopy, recordings of cell behaviour can result in terabyte-size datasets. The lattice light sheet microscope…”
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A Multicenter Analysis of Distal Pancreatectomy for Adenocarcinoma: Is Laparoscopic Resection Appropriate? by Kooby, David A., MD, FACS, Hawkins, William G., MD, FACS, Schmidt, C. Max, MD, PhD, FACS, Weber, Sharon M., MD, FACS, Bentrem, David J., MD, MS, FACS, Gillespie, Theresa W., PhD, Sellers, Johnita Byrd, MS, Merchant, Nipun B., MD, FACS, Scoggins, Charles R., MD, MBA, FACS, Martin, Robert C.G., MD, PhD, FACS, Kim, Hong Jin, MD, FACS, Ahmad, Syed, MD, FACS, Cho, Clifford S., MD, Parikh, Alexander A., MD, FACS, Chu, Carrie K., MD, Hamilton, Nicholas A., MD, Doyle, Courtney J., MD, Pinchot, Scott, MD, Hayman, Amanda, MD, MPH, McClaine, Rebecca, MD, Nakeeb, Attila, MD, FACS, Staley, Charles A., MD, FACS, McMasters, Kelly M., MD, PhD, FACS, Lillemoe, Keith D., MD, FACS

“…Background As compared with open distal pancreatectomy (ODP), laparoscopic distal pancreatectomy (LDP) affords improved perioperative outcomes. The role of LDP…”
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Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1 by Liang, Xuan, Budnar, Srikanth, Gupta, Shafali, Verma, Suzie, Han, Siew-Ping, Hill, Michelle M., Daly, Roger J., Parton, Robert G., Hamilton, Nicholas A., Gomez, Guillermo A., Yap, Alpha S.

“…Contractile adherens junctions support cell−cell adhesion, epithelial integrity, and morphogenesis. Much effort has been devoted to understanding how…”
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Fast automated cell phenotype image classification by Hamilton, Nicholas A, Pantelic, Radosav S, Hanson, Kelly, Teasdale, Rohan D

“…The genomic revolution has led to rapid growth in sequencing of genes and proteins, and attention is now turning to the function of the encoded proteins. In…”
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Ki-67 predicts disease recurrence and poor prognosis in pancreatic neuroendocrine neoplasms by Hamilton, Nicholas A., MD, Liu, Ta-Chiang, MD, PhD, Cavatiao, Antonino, BS, Mawad, Kareem, MD, Chen, Ling, PhD, Strasberg, Steven S., MD, Linehan, David C., MD, Cao, Dengfeng, MD, PhD, Hawkins, William G., MD

“…Background Pancreatic neuroendocrine neoplasms are rare malignancies for which the ideal staging method remains controversial. Ki-67 is a cell proliferation…”
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A cost and outcome analysis of pediatric single incision appendectomy by Wieck, Minna M., MD, Hamilton, Nicholas A., MD, Krishnaswami, Sanjay, MD

“…Abstract Background For appendicitis, single-incision laparoscopic appendectomy (SIA) has been proposed as an alternative to 3-port appendectomy (3PA)…”
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An integrated pipeline for the multidimensional analysis of branching morphogenesis by Combes, Alexander N, Short, Kieran M, Lefevre, James, Hamilton, Nicholas A, Little, Melissa H, Smyth, Ian M

“…In this Protocol, data obtained from optical projection tomography and confocal microscopy is analyzed with Tree Surveyor and Imaris to obtain information…”
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Postlipolytic insulin-dependent remodeling of micro lipid droplets in adipocytes by Ariotti, Nicholas, Murphy, Samantha, Hamilton, Nicholas A, Wu, Lizhen, Green, Kathryn, Schieber, Nicole L, Li, Peng, Martin, Sally, Parton, Robert G

“…Despite the lipolysis-lipogenesis cycle being a fundamental process in adipocyte biology, very little is known about the morphological changes that occur…”
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Non-melanoma skin cancer segmentation for histopathology dataset by Thomas, Simon M., Lefevre, James G., Baxter, Glenn, Hamilton, Nicholas A.

“…Densely labelled segmentation data for digital pathology images is costly to produce but is invaluable to training effective machine learning models. We make…”
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Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration by Short, Kieran M, Combes, Alexander N, Lisnyak, Valerie, Lefevre, James G, Jones, Lynelle K, Little, Melissa H, Hamilton, Nicholas A, Smyth, Ian M

“…Branching morphogenesis of the ureteric bud is integral to kidney development; establishing the collecting ducts of the adult organ and driving organ expansion…”
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Rapid Surveillance for Vector Presence (RSVP): Development of a novel system for detecting Aedes aegypti and Aedes albopictus by Montgomery, Brian L, Shivas, Martin A, Hall-Mendelin, Sonja, Edwards, Jim, Hamilton, Nicholas A, Jansen, Cassie C, McMahon, Jamie L, Warrilow, David, van den Hurk, Andrew F

“…The globally important Zika, dengue and chikungunya viruses are primarily transmitted by the invasive mosquitoes, Aedes aegypti and Aedes albopictus. In…”
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Hepatocyte Growth Factor Acutely Perturbs Actin Filament Anchorage at the Epithelial Zonula Adherens by Mangold, Sabine, Wu, Selwin K., Norwood, Suzanne J., Collins, Brett M., Hamilton, Nicholas A., Thorn, Peter, Yap, Alpha S.

“…Cadherin adhesion molecules function in close cooperation with the actin cytoskeleton. At the zonula adherens (ZA) of polarized epithelial cells, E-cadherin…”
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RAZA: A Rapid 3D z-crossings algorithm to segment electron tomograms and extract organelles and macromolecules by Ali, Rubbiya A., Mehdi, Ahmed M., Rothnagel, Rosalba, Hamilton, Nicholas A., Gerle, Christoph, Landsberg, Michael J., Hankamer, Ben

“…Resolving the 3D architecture of cells to atomic resolution is one of the most ambitious challenges of cellular and structural biology. Central to this process…”
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The Recycling Endosome Protein Rab17 Regulates Melanocytic Filopodia Formation and Melanosome Trafficking by Beaumont, Kimberley A., Hamilton, Nicholas A., Moores, Matthew T., Brown, Darren L., Ohbayashi, Norihiko, Cairncross, Oliver, Cook, Anthony L., Smith, Aaron G., Misaki, Ryo, Fukuda, Mitsunori, Taguchi, Tomohiko, Sturm, Richard A., Stow, Jennifer L.

“…Rab GTPases including Rab27a, Rab38 and Rab32 function in melanosome maturation or trafficking in melanocytes. A screen to identify additional Rabs involved in…”
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Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella by Kerr, Markus C, Wang, Jack T H, Castro, Natalie A, Hamilton, Nicholas A, Town, Liam, Brown, Darren L, Meunier, Frederic A, Brown, Nat F, Stow, Jennifer L, Teasdale, Rohan D

“…3‐phosphorylated phosphoinositides (3‐PtdIns) orchestrate endocytic trafficking pathways exploited by intracellular pathogens such as Salmonella to gain entry…”
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