Search Results - "Hamilton, Karyn"

Can exercise prevent the age‐related decline in adaptive homeostasis? Evidence across organisms and tissues by Hamilton, Karyn L., Selman, Colin

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Peer review: the imprimatur of scientific publication by Berg, Ronan M. G., Hamilton, Karyn L., Murray, Joanne Fiona, Fong, Peying

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Exercise-Induced Mitohormesis for the Maintenance of Skeletal Muscle and Healthspan Extension by Musci, Robert V, Hamilton, Karyn L, Linden, Melissa A

“…Oxidative damage is one mechanism linking aging with chronic diseases including the progressive loss of skeletal muscle mass and function called sarcopenia…”
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Mitochondrial proteostasis as a shared characteristic of slowed aging: the importance of considering cell proliferation by Hamilton, Karyn L., Miller, Benjamin F.

“…Proteostasis is one of the seven “pillars of aging research” identified by the Trans‐NIH Geroscience Initiative and loss of proteostasis is associated with…”
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A practical perspective on how to develop, implement, execute, and reproduce high‐resolution respirometry experiments: The physiologist's guide to an Oroboros O2k by Walsh, Maureen A., Musci, Robert V., Jacobs, Robert A., Hamilton, Karyn L.

“…The development of high‐resolution respirometry (HRR) has greatly expanded the analytical scope to study mitochondrial respiratory control relative to specific…”
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Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults by Konopka, Adam R., Laurin, Jaime L., Schoenberg, Hayden M., Reid, Justin J., Castor, William M., Wolff, Christopher A., Musci, Robert V., Safairad, Oscar D., Linden, Melissa A., Biela, Laurie M., Bailey, Susan M., Hamilton, Karyn L., Miller, Benjamin F.

“…Metformin and exercise independently improve insulin sensitivity and decrease the risk of diabetes. Metformin was also recently proposed as a potential therapy…”
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Peer review: the imprimatur of scientific publication by Berg, Ronan M. G., Hamilton, Karyn L., Murray, Joanne Fiona, Fong, Peying

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The combination of NRF1 and Nrf2 activators in myoblasts stimulate mechanisms of proteostasis without changes in mitochondrial respiration by Walsh, Maureen A., Zhang, Qian, Musci, Robert V., Hamilton, Karyn L.

“…Persistent oxidative stress contributes to hallmarks of aging, including impaired proteostasis and mitochondrial dysfunction, while acute oxidative challenges…”
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The rigorous study of exercise adaptations: why mRNA might not be enough by Miller, Benjamin F, Konopka, Adam R, Hamilton, Karyn L

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Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer by Strong, Randy, Miller, Richard A., Antebi, Adam, Astle, Clinton M., Bogue, Molly, Denzel, Martin S., Fernandez, Elizabeth, Flurkey, Kevin, Hamilton, Karyn L., Lamming, Dudley W., Javors, Martin A., Magalhães, João Pedro, Martinez, Paul Anthony, McCord, Joe M., Miller, Benjamin F., Müller, Michael, Nelson, James F., Ndukum, Juliet, Rainger, G. Ed, Richardson, Arlan, Sabatini, David M., Salmon, Adam B., Simpkins, James W., Steegenga, Wilma T., Nadon, Nancy L., Harrison, David E.

“…Summary The National Institute on Aging Interventions Testing Program (ITP) evaluates agents hypothesized to increase healthy lifespan in genetically…”
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A perspective on the determination of mitochondrial biogenesis by Miller, Benjamin F, Hamilton, Karyn L

“…The measurement of mitochondrial biogenesis is important in the determination of aging and disease processes and the assessment of countermeasurements to them…”
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Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an [alpha]-glucosidase inhibitor or a Nrf2-inducer by Strong, Randy, Miller, Richard A, Antebi, Adam, Astle, Clinton M, Bogue, Molly, Denzel, Martin S, Fernandez, Elizabeth, Flurkey, Kevin, Hamilton, Karyn L, Lamming, Dudley W, Javors, Martin A, Magalhaes, João Pedro, Martinez, Paul Anthony, McCord, Joe M, Miller, Benjamin F, Muller, Michael, Nelson, James F, Ndukum, Juliet, Rainger, G Ed, Richardson, Arlan, Sabatini, David M, Salmon, Adam B, Simpkins, James W, Steegenga, Wilma T, Nadon, Nancy L, Harrison, David E

“…Summary The National Institute on Aging Interventions Testing Program (ITP) evaluates agents hypothesized to increase healthy lifespan in genetically…”
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The ketogenic diet preserves skeletal muscle with aging in mice by Wallace, Marita A., Aguirre, Nicholas W., Marcotte, George R., Marshall, Andrea G., Baehr, Leslie M., Hughes, David C., Hamilton, Karyn L., Roberts, Megan N., Lopez‐Dominguez, Jose Alberto, Miller, Benjamin F., Ramsey, Jon J., Baar, Keith

“…The causes of the decline in skeletal muscle mass and function with age, known as sarcopenia, are poorly understood. Nutrition (calorie restriction)…”
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Pigmented and Dunkin‐Hartley Guinea Pigs as Natural Models for Brain Aging and Alzheimer’s Disease by Wahl, Devin, Moreno, Julie, Santangelo, Kelly, Cavalier, Alyssa N., Hamilton, Karyn L., LaRocca, Thomas J.

“…Aging is the primary risk factor for most chronic diseases, including Alzheimer’s disease (AD). Current pre‐clinical approaches for studying brain aging and AD…”
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Mechanisms of In Vivo Ribosome Maintenance Change in Response to Nutrient Signals by Mathis, Andrew D., Naylor, Bradley C., Carson, Richard H., Evans, Eric, Harwell, Justin, Knecht, Jared, Hexem, Eric, Peelor, Fredrick F., Miller, Benjamin F., Hamilton, Karyn L., Transtrum, Mark K., Bikman, Benjamin T., Price, John C.

“…Control of protein homeostasis is fundamental to the health and longevity of all organisms. Because the rate of protein synthesis by ribosomes is a central…”
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Muscle‐specific changes in protein synthesis with aging and reloading after disuse atrophy by Miller, Benjamin F., Baehr, Leslie M., Musci, Robert V., Reid, Justin J., Peelor, Frederick F., Hamilton, Karyn L., Bodine, Sue C.

“…Background Successful strategies to halt or reverse sarcopenia require a basic understanding of the factors that cause muscle loss with age. Acute periods of…”
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Targeting mitochondrial function and proteostasis to mitigate dynapenia by Musci, Robert V., Hamilton, Karyn L., Miller, Benjamin F.

“…Traditionally, interventions to treat skeletal muscle aging have largely targeted sarcopenia—the age-related loss of skeletal muscle mass. Dynapenia refers to…”
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A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction by Miller, Benjamin F., Robinson, Matthew M, Bruss, Matthew D., Hellerstein, Marc, Hamilton, Karyn L.

“…Summary It is proposed that caloric restriction (CR) increases mitochondrial biogenesis. However, it is not clear why CR increases an energetically costly…”
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A viewpoint on considering physiological principles to study stress resistance and resilience with aging by Miller, Benjamin F, Seals, Douglas R, Hamilton, Karyn L

“…Adaptation to stress is identified as one of the seven pillars of aging research. Our viewpoint discusses the importance of the distinction between stress…”
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Modeling the contribution of individual proteins to mixed skeletal muscle protein synthetic rates over increasing periods of label incorporation by Miller, Benjamin F, Wolff, Christopher A, Peelor, 3rd, Fredrick F, Shipman, Patrick D, Hamilton, Karyn L

“…Advances in stable isotope approaches, primarily the use of deuterium oxide ((2)H2O), allow for long-term measurements of protein synthesis, as well as the…”
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