Search Results - "Hamilton, Kara L"

Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis by Grosse, Ann S, Pressprich, Mark F, Curley, Lauren B, Hamilton, Kara L, Margolis, Ben, Hildebrand, Jeffrey D, Gumucio, Deborah L

“…The cellular mechanisms that drive growth and remodeling of the early intestinal epithelium are poorly understood. Current dogma suggests that the murine fetal…”
Get full text

A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry by Rajabli, Farid, Beecham, Gary W, Hendrie, Hugh C, Baiyewu, Olusegun, Ogunniyi, Adesola, Gao, Sujuan, Kushch, Nicholas A, Lipkin-Vasquez, Marina, Hamilton-Nelson, Kara L, Young, Juan I, Dykxhoorn, Derek M, Nuytemans, Karen, Kunkle, Brian W, Wang, Liyong, Jin, Fulai, Liu, Xiaoxiao, Feliciano-Astacio, Briseida E, Schellenberg, Gerard D, Dalgard, Clifton L, Griswold, Anthony J, Byrd, Goldie S, Reitz, Christiane, Cuccaro, Michael L, Haines, Jonathan L, Pericak-Vance, Margaret A, Vance, Jeffery M

“…African descent populations have a lower Alzheimer disease risk from ApoE ε4 compared to other populations. Ancestry analysis showed that the difference in…”
Get full text

Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer’s disease by Zhang, Lanyu, Silva, Tiago C., Young, Juan I., Gomez, Lissette, Schmidt, Michael A., Hamilton-Nelson, Kara L., Kunkle, Brian W., Chen, Xi, Martin, Eden R., Wang, Lily

“…DNA methylation differences in Alzheimer’s disease (AD) have been reported. Here, we conducted a meta-analysis of more than 1000 prefrontal cortex brain…”
Get full text

Salivary Soluble CD44: A Potential Molecular Marker for Head and Neck Cancer by FRANZMANN, Elizabeth J, REATEGUI, Erika P, CARRAWAY, Kermit L, HAMILTON, Kara L, WEED, Donald T, JARRARD GOODWIN, W

“…Objective: Head and neck squamous cell carcinoma (HNSCC) is a debilitating disease which is cured only 50% of the time. If diagnosed early, survival rates…”
Get full text

Genome-wide association analysis and admixture mapping in a Puerto Rican cohort supports an Alzheimer disease risk locus on chromosome 12 by Akgun, Bilcag, Feliciano-Astacio, Briseida E, Hamilton-Nelson, Kara L, Scott, Kyle, Rivero, Joe, Adams, Larry D, Sanchez, Jose J, Valladares, Glenies S, Tejada, Sergio, Bussies, Parker L, Silva-Vergara, Concepcion, Rodriguez, Vanessa C, Mena, Pedro R, Celis, Katrina, Whitehead, Patrice G, Prough, Michael, Kosanovic, Christina, Van Booven, Derek J, Schmidt, Michael A, Acosta, Heriberto, Griswold, Anthony J, Dalgard, Clifton L, McInerney, Katalina F, Beecham, Gary W, Cuccaro, Michael L, Vance, Jeffery M, Pericak-Vance, Margaret A, Rajabli, Farid

“…Hispanic/Latino populations are underrepresented in Alzheimer Disease (AD) genetic studies. Puerto Ricans (PR), a three-way admixed (European, African, and…”
Get full text

Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds by Griswold, Anthony J., Celis, Katrina, Bussies, Parker L., Rajabli, Farid, Whitehead, Patrice L., Hamilton‐Nelson, Kara L., Beecham, Gary W., Dykxhoorn, Derek M., Nuytemans, Karen, Wang, Liyong, Gardner, Olivia K., Dorfsman, Daniel A., Bigio, Eileen H., Mesulam, Marek Marsel, Weintraub, Sandra, Geula, Changiz, Gearing, Marla, McGrath‐Martinez, Elisa, Dalgard, Clifton L., Scott, William K., Haines, Jonathan L., Pericak‐Vance, Margaret A., Young, Juan I., Vance, Jeffery M.

“…Introduction Apolipoprotein E (APOE) ε4 confers less risk for Alzheimer's disease (AD) in carriers with African local genomic ancestry (ALA) than APOE ε4…”
Get full text

RNA editing alterations in a multi-ethnic Alzheimer disease cohort converge on immune and endocytic molecular pathways by Gardner, Olivia K, Wang, Lily, Van Booven, Derek, Whitehead, Patrice L, Hamilton-Nelson, Kara L, Adams, Larry D, Starks, Takiyah D, Hofmann, Natalia K, Vance, Jeffery M, Cuccaro, Michael L, Martin, Eden R, Byrd, Goldie S, Haines, Jonathan L, Bush, William S, Beecham, Gary W, Pericak-Vance, Margaret A, Griswold, Anthony J

“…Little is known about the post-transcriptional mechanisms that modulate the genetic effects in the molecular pathways underlying Alzheimer disease (AD), and…”
Get full text

Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans by Rajabli, Farid, Tosto, Giuseppe, Hamilton‐Nelson, Kara L., Kunkle, Brian W., Vardarajan, Badri N., Naj, Adam, Whitehead, Patrice G., Gardner, Olivia K., Bush, William S., Sariya, Sanjeev, Mayeux, Richard P., Farrer, Lindsay A., Cuccaro, Michael L., Vance, Jeffrey M., Griswold, Anthony J., Schellenberg, Gerard D., Haines, Jonathan L., Byrd, Goldie S., Reitz, Christiane, Beecham, Gary W., Pericak‐Vance, Margaret A., Martin, Eden R.

“…Background This study used admixture mapping to prioritize the genetic regions associated with Alzheimer's disease (AD) in African American (AA) individuals,…”
Get full text

African locus reduces the effect of ApoE ε4 allele in Alzheimer’s disease by Rajabli, Farid, Kunkle, Brian W., Reitz, Christiane, Hendrie, Hugh C, Baiyewu, Olusegun, Ogunniyi, Adesola, Gao, Sujuan, Kushch, Nicholas A., Hamilton‐Nelson, Kara L., Beecham, Gary W., Pericak‐Vance, Margaret A., Vance, Jeffery M.

“…Background Strong associations between ApoE ε4 and Alzheimer disease (AD) risk have been confirmed worldwide, but there is variability in the effect size…”
Get full text

Linkage analysis identifies novel loci in early‐onset Alzheimer disease in non‐Hispanic white families by Jean‐Francois, Melissa N., Pericak‐Vance, Margaret A., da Fonseca, Eder Lucio, Baez, Penelope, Ayodele, Temitope, Welch, Jacob, Hamilton‐Nelson, Kara L., Martin, Eden R., Cuccaro, Michael L., Reitz, Christiane, Beecham, Gary W.

“…Background Early‐onset Alzheimer disease (EOAD) is a highly genetic dementia typically defined as Alzheimer disease dementia with an age of onset of 65 years…”
Get full text

The Puerto Rico Alzheimer Disease Initiative (PRADI): A Multisource Ascertainment Approach by Feliciano-Astacio, Briseida E, Celis, Katrina, Ramos, Jairo, Rajabli, Farid, Adams, Larry Deon, Rodriguez, Alejandra, Rodriguez, Vanessa, Bussies, Parker L, Sierra, Carolina, Manrique, Patricia, Mena, Pedro R, Grana, Antonella, Prough, Michael, Hamilton-Nelson, Kara L, Feliciano, Nereida, Chinea, Angel, Acosta, Heriberto, McCauley, Jacob L, Vance, Jeffery M, Beecham, Gary W, Pericak-Vance, Margaret A, Cuccaro, Michael L

“…Puerto Ricans, the second largest Latino group in the continental US, are underrepresented in genomic studies of Alzheimer disease (AD). To increase…”
Get full text

Expression quantitative trait loci (eQTL) analysis in a diverse Alzheimer disease cohort reveals ancestry‐specific regulatory architectures by Griswold, Anthony J., Gardner, Olivia K., Feliciano‐Astacio, Briseida E., Van Booven, Derek, Hamilton‐Nelson, Kara L., Whitehead, Patrice L., Adams, Larry D., Starks, Takiyah D., Acosta, Heriberto, Cuccaro, Michael L., Vance, Jeffery M., Byrd, Goldie S., Haines, Jonathan L., Bush, William S., Beecham, Gary W., Pericak‐Vance, Margaret A.

“…Background Generalization of Alzheimer disease (AD) genetic findings to ancestrally admixed populations, such as African Americans (AA) and Caribbean Hispanics…”
Get full text

Admixture mapping identifies novel regions influencing Alzheimer disease in African Americans by Hamilton‐Nelson, Kara L., Rajabli, Farid, Kunkle, Brian W., Tosto, Giuseppe, Reitz, Christiane, Naj, Adam C, Whitehead, Patrice L., Kushch, Nicholas A., Beecham, Gary W., Byrd, Goldie S., Bush, William S., Mayeux, Richard, Farrer, Lindsay A., Haines, Jonathan L., Schellenberg, Gerard D., Pericak‐Vance, Margaret A., Martin, Eden R

“…Background African Americans (AA) are substantially underrepresented in Alzheimer's disease (AD) genetic studies, yet their admixed genetic ancestry (African…”
Get full text

Characterization of CD44v3 containing isoforms in head and neck cancer by Reategui, Erika P, Mayolo, Adriana Antúnez de, Das, Parpha M., Astor, Frank C., Singal, Rakesh, Hamilton, Kara L., Goodwin, W. Jarrard, Carraway, Kermit L., Franzmann, Elizabeth J.

“…Head and neck squamous cell carcinoma (HNSCC) is a debilitating and deadly disease that is only cured 50% of the time. A better understanding of the molecular…”
Get full text

APOE‐stratified genome‐wide association analysis identifies novel Alzheimer disease candidate risk loci for African Americans by Kunkle, Brian W., Jean‐Francois, Melissa N., Hamilton‐Nelson, Kara L., Schmidt, Michael A., Naj, Adam C, Martin, Eden R, Vance, Jeffery M., Cuccaro, Michael L., Rajabli, Farid, Jun, Gyungah R, Wang, Li‐San, Farrer, Lindsay A., Haines, Jonathan L., Byrd, Goldie S., Schellenberg, Gerard D., Mayeux, Richard, Beecham, Gary W., Pericak‐Vance, Margaret A., Reitz, Christiane

“…Background We recently published a genome‐wide association study (GWAS) for Alzheimer disease (AD) in African Americans (AA; 2,784 cases, 5,222 cognitively…”
Get full text

African Ancestry Individuals with Higher Educational Attainment Are Resilient to Alzheimer's Disease Measured by pTau181 by Rajabli, Farid, Seixas, Azizi A, Akgun, Bilcag, Adams, Larry D, Inciute, Jovita, Hamilton, Kara L, Whithead, Patrice G, Konidari, Ioanna, Gu, Tianjie, Arvizu, Jamie, Golightly, Charles G, Starks, Takiyah D, Laux, Renee, Byrd, Goldie S, Haines, Jonathan L, Beecham, Gary W, Griswold, Anthony J, Vance, Jeffery M, Cuccaro, Michael L, Pericak-Vance, Margaret A

“…Cognitive and functional abilities in individuals with Alzheimer's disease (AD) pathology (ADP) are highly variable. Factors contributing to this variability…”
Get more information

Positive surgical margins after radical retropubic prostatectomy: the influence of site and number on progression by Sofer, Mario, Hamilton-Nelson, Kara L, Civantos, Francisco, Soloway, Mark S

“…We assessed the effect of location and number of positive margins on biochemical progression in patients after radical retropubic prostatectomy for prostate…”
Get more information

Risk of Positive Margins and Biochemical Recurrence in Relation to Nerve-Sparing Radical Prostatectomy by Sofer, Mario, Hamilton-Nelson, Kara L, Schlesselman, James J, Soloway, Mark S

“…To assess the effect of nerve-sparing (NS) radical retropubic prostatectomy (RRP) on surgical margins and biochemical recurrence. Location and incidence of…”
Get full text

Exploring the Relationship Between Autism Spectrum Disorder and Epilepsy Using Latent Class Cluster Analysis by Cuccaro, Michael L., Tuchman, Roberto F., Hamilton, Kara L., Wright, Harry H., Abramson, Ruth K., Haines, Jonathan L., Gilbert, John R., Pericak-Vance, Margaret

“…Epilepsy co-occurs frequently in autism spectrum disorders (ASD). Understanding this co-occurrence requires a better understanding of the ASD-epilepsy…”
Get full text

A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice by Tapanes-Castillo, Alexis, Weaver, Eli J., Smith, Robin P., Kamei, Yoshimasa, Caspary, Tamara, Hamilton-Nelson, Kara L., Slifer, Susan H., Martin, Eden R., Bixby, John L., Lemmon, Vance P.

“…Humans with L1 cell adhesion molecule ( L1CAM ) mutations exhibit X-linked hydrocephalus, as well as other severe neurological disorders. L1-6D mutant mice,…”
Get full text