Search Results - "Hamilton, John A."

GM-CSF in inflammation by Hamilton, John A

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) has many more functions than its original in vitro identification as an inducer of granulocyte and…”
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GM-CSF-Dependent Inflammatory Pathways by Hamilton, John A

“…Pre-clinical models and clinical trials demonstrate that targeting the action of the cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), can…”
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Colony-stimulating factors in inflammation and autoimmunity by Hamilton, John A

“…Key Points Colony-stimulating factors (CSFs) — granulocyte/macrophage CSF (GM-CSF), macrophage CSF (M-CSF) and granulocyte CSF (G-CSF) — have wider functions…”
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Colony stimulating factors and myeloid cell biology in health and disease by Hamilton, John A, Achuthan, Adrian

“…The colony stimulating factors (CSFs), granulocyte macrophage-CSF (GM-CSF), macrophage-CSF (M-CSF or CSF-1) and granulocyte-CSF (G-CSF) were first identified…”
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Therapeutic options for targeting inflammatory osteoarthritis pain by Conaghan, Philip G., Cook, Andrew D., Hamilton, John A., Tak, Paul P.

“…Pain is the major symptom of osteoarthritis (OA) and is an important factor in strategies to manage this disease. However, the current standard of care does…”
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Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases by Hamilton, John A., Cook, Andrew D., Tak, Paul P.

“…Key Points Colony-stimulating factors (CSFs) are pleiotropic, but each has its own unique biological role. All CSFs control myeloid cell numbers, but each has…”
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Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry by Huang, Yu-Kuan, Wang, Minyu, Sun, Yu, Di Costanzo, Natasha, Mitchell, Catherine, Achuthan, Adrian, Hamilton, John A., Busuttil, Rita A., Boussioutas, Alex

“…Tumor-associated macrophages (TAMs), one of the most abundant immune components in gastric cancer (GC), are difficult to characterize due to their…”
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GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential by Hamilton, John A

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) can be viewed as a pro-inflammatory cytokine rather than as a key regulator of steady state and…”
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Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models by Lacey, Derek C, Achuthan, Adrian, Fleetwood, Andrew J, Dinh, Hang, Roiniotis, John, Scholz, Glen M, Chang, Melody W, Beckman, Sandra K, Cook, Andrew D, Hamilton, John A

“…GM-CSF and M-CSF (CSF-1) induce different phenotypic changes in macrophage lineage populations. The nature, extent, and generality of these differences were…”
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K/BxN Serum-Transfer Arthritis as a Model for Human Inflammatory Arthritis by Christensen, Anne D, Haase, Claus, Cook, Andrew D, Hamilton, John A

“…The K/BxN serum-transfer arthritis (STA) model is a murine model in which the immunological mechanisms occurring in rheumatoid arthritis (RA) and other…”
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Targeting transcription factors for therapeutic benefit in rheumatoid arthritis by Balendran, Thivya, Lim, Keith, Hamilton, John A, Achuthan, Adrian A

“…Rheumatoid arthritis (RA) is a destructive inflammatory autoimmune disease that causes pain and disability. Many of the currently available drugs for treating…”
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GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling by Fleetwood, Andrew J., Dinh, Hang, Cook, Andrew D., Hertzog, Paul J, Hamilton, John A.

“…Type I IFN differentially regulates the phenotype, function and polarization of particular macrophage populations. M‐CSF and GM‐CSF are mediators involved in…”
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Granulocyte-Macrophage Colony-Stimulating Factor (CSF) and Macrophage CSF-Dependent Macrophage Phenotypes Display Differences in Cytokine Profiles and Transcription Factor Activities: Implications for CSF Blockade in Inflammation by Fleetwood, Andrew J, Lawrence, Toby, Hamilton, John A, Cook, Andrew D

“…GM-CSF and M-CSF (CSF-1) can enhance macrophage lineage numbers as well as modulate their differentiation and function. Of recent potential significance for…”
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CCL17 blockade as a therapy for osteoarthritis pain and disease by Lee, Ming-Chin, Saleh, Reem, Achuthan, Adrian, Fleetwood, Andrew J, Förster, Irmgard, Hamilton, John A, Cook, Andrew D

“…Granulocyte macrophage-colony stimulating factor (GM-CSF) has been implicated in the pathogenesis of a number of inflammatory diseases and in osteoarthritis…”
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Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages by Hsu, Amy T., Lupancu, Tanya J., Lee, Ming-Chin, Fleetwood, Andrew J., Cook, Andrew D., Hamilton, John A., Achuthan, Adrian

“…Interleukin 4 (IL4) is generally viewed as a Th2 cytokine capable of polarizing macrophages into an anti-inflammatory phenotype, whereas granulocyte…”
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The mode of action of IL-23 in experimental inflammatory arthritic pain and disease by Lee, Kevin M-C, Lupancu, Tanya, Chang, Leon, Manthey, Carl L, Zeeman, Martha, Fourie, Anne M, Hamilton, John A

“…We have previously reported using gene-deficient mice that the interleukin (IL)-23p19 subunit is required for the development of innate immune-driven arthritic…”
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Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles by Fleetwood, Andrew J, Lee, Man K S, Singleton, William, Achuthan, Adrian, Lee, Ming-Chin, O'Brien-Simpson, Neil M, Cook, Andrew D, Murphy, Andrew J, Dashper, Stuart G, Reynolds, Eric C, Hamilton, John A

“…is one of the bacterial species most closely associated with periodontitis and can shed large numbers of outer membrane vesicles (OMVs), which are increasingly…”
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Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation by Achuthan, Adrian, Cook, Andrew D, Lee, Ming-Chin, Saleh, Reem, Khiew, Hsu-Wei, Chang, Melody W N, Louis, Cynthia, Fleetwood, Andrew J, Lacey, Derek C, Christensen, Anne D, Frye, Ashlee T, Lam, Pui Yeng, Kusano, Hitoshi, Nomura, Koji, Steiner, Nancy, Förster, Irmgard, Nutt, Stephen L, Olshansky, Moshe, Turner, Stephen J, Hamilton, John A

“…Data from preclinical and clinical studies have demonstrated that granulocyte macrophage colony-stimulating factor (GM-CSF) can function as a key…”
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The role of interleukin (IL)-23 in regulating pain in arthritis by Lee, Kevin M-C, Sherlock, Jonathan P, Hamilton, John A

“…Current understanding of IL-23 biology, with its link to other pro-inflammatory cytokines, for example, IL-17 and granulocyte macrophage-colony stimulating…”
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Specific Contributions of CSF-1 and GM-CSF to the Dynamics of the Mononuclear Phagocyte System by Louis, Cynthia, Cook, Andrew D, Lacey, Derek, Fleetwood, Andrew J, Vlahos, Ross, Anderson, Gary P, Hamilton, John A

“…M-CSF (or CSF-1) and GM-CSF can regulate the development and function of the mononuclear phagocyte system (MPS). To address some of the outstanding and…”
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