Search Results - "Hamilton, Jacob T."
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Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination
Published in Immunity (Cambridge, Mass.) (14-09-2021)“…SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions remain about the nature and kinetics of T cell priming. We performed…”
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Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine
Published in Cell (26-05-2022)“…We examined antibody and memory B cell responses longitudinally for ∼9–10 months after primary 2-dose SARS-CoV-2 mRNA vaccination and 3 months after a 3rd…”
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Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination
Published in Science immunology (15-04-2021)“…Novel mRNA vaccines for SARS-CoV-2 have been authorized for emergency use. Despite their efficacy in clinical trials, data on mRNA vaccine-induced immune…”
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Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
Published in Science (American Association for the Advancement of Science) (04-09-2020)“…Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional…”
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mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern
Published in Science (American Association for the Advancement of Science) (03-12-2021)“…The durability of immune memory after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccination remains unclear. In this…”
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Cytomegalovirus Latent Infection is Associated with an Increased Risk of COVID-19-Related Hospitalization
Published in The Journal of infectious diseases (26-08-2022)“…Abstract Some risk factors for severe coronavirus disease 2019 (COVID-19) have been identified, including age, race, and obesity. However, 20%–50% of severe…”
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Immunologic predictors of vaccine responsiveness in patients with lymphoma and CLL
Published in The Journal of infectious diseases (04-03-2024)“…Patients with B-cell lymphomas have altered cellular components of vaccine responses due to malignancy and therapy, and the optimal timing of vaccination…”
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Immunologic Predictors of Vaccine Responsiveness in Patients With Lymphoma and Chronic Lymphocytic Leukemia
Published in The Journal of infectious diseases (25-07-2024)“…Patients with B-cell lymphomas have altered cellular components of vaccine responses due to malignancy and therapy, and the optimal timing of vaccination…”
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Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19
Published in Frontiers in immunology (03-03-2022)“…Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality…”
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