Search Results - "Hamilton, Gregory S."

Antibody-drug conjugates for cancer therapy: The technological and regulatory challenges of developing drug-biologic hybrids by Hamilton, Gregory S.

“…Antibody-drug conjugates (ADCs) are a new class of therapeutic agents that combine the targeting ability of monoclonal antibodies (mAbs) with small molecule…”
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Neurotrophic Immunophilin Ligands Stimulate Structural and Functional Recovery in Neurodegenerative Animal Models by Steiner, Joseph P., Hamilton, Gregory S., Ross, Douglas T., Valentine, Heather L., Guo, Hongzhi, Connolly, Maureen A., Liang, Shi, Ramsey, Cynthia, Li, Jia-He J., Huang, Wei, Howorth, Pamela, Soni, Rajat, Fuller, Michael, Sauer, Hans, Nowotnik, Alison C., Suzdak, Peter D.

“…Although immunosuppressant immunophilin ligands promote neurite outgrowth in vitro, their neurotrophic activities are clearly independent of their…”
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Direct Synthesis of Guanidines Using Di(imidazole-1-yl)methanimine by Wu, Yong-Qian, Hamilton, Sean K, Wilkinson, Douglas E, Hamilton, Gregory S

“…A direct synthetic approach to guanidine compounds is reported here using di(imidazole-1-yl)methanimine and di(imidazole-1-yl)cyanomethanimine as guanylating…”
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A mild deprotection procedure for tert-butyl esters and tert-butyl ethers using ZnBr2 in methylene chloride by Wu, Yong-qian, Limburg, David C, Wilkinson, Douglas E, Vaal, Mark J, Hamilton, Gregory S

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Rigid molecular tweezers: preorganized hosts for electron donor-acceptor complexation in organic solvents by Zimmerman, Steven C, VanZyl, Craig M, Hamilton, Gregory S

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Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A by Steiner, Joseph P, Connolly, Maureen A, Valentine, Heather L, Hamilton, Gregory S, Dawson, Ted M, Hester, Lynda, Snyder, Solomon H

“…We show that the nonimmunosuppressive analogues of the immunosuppressive drugs FK506, rapamycin and cyclosporin A promote neurite outgrowth both in PC12 cells…”
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1-Cyanoimidazole as a Mild and Efficient Electrophilic Cyanating Agent by Wu, Yong-qian, Limburg, David C, Wilkinson, Douglas E, Hamilton, Gregory S

“…A mild and high-yielding cyanating reaction of amine, sulfur, and carbanion nucleophiles is reported here using 1-cyanoimidazole as an electrophilic cyanating…”
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Microwave-Assisted Synthesis of N,N ‘-Diaryl Cyanoguanidines by Hamilton, Sean K, Wilkinson, Doug E, Hamilton, Gregory S, Wu, Yong-Qian

“…A mild, efficient, and high-yielding method for the synthesis of N,N‘-diaryl cyanoguanidines from their corresponding thioureas under microwave-assisted…”
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Fluorenylalkanoic and Benzoic Acids as Novel Inhibitors of Cell Adhesion Processes in Leukocytes by Hamilton, Gregory S, Mewshaw, Richard E, Bryant, Carmen M, Feng, Ying, Endemann, Gerda, Madden, Kip S, Danczak, Jennifer E, Perumattam, John, Stanton, Lawrence W

“…A series of fluoren-9-ylalkanoic and alkylbenzoic acids was prepared as simplified analogues of a previously reported series of antiinflammatory agents which…”
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Synthesis and neurotrophic activity of nonimmunosuppressant cyclosporin A derivatives by Wei, Ling, Steiner, Joseph P, Hamilton, Gregory S, Wu, Yong-Qian

“…In order to exploit cyclophilin as a potential target for neurological drug design, we demonstrate in this presentation that several nonimmunosuppressant…”
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Synthesis of N-Glyoxyl Prolyl and Pipecolyl Amides and Thioesters and Evaluation of Their In Vitro and In Vivo Nerve Regenerative Effects by Hamilton, Gregory S, Wu, Yong-Qian, Limburg, David C, Wilkinson, Douglas E, Vaal, Mark J, Li, Jia-He, Thomas, Christine, Huang, Wei, Sauer, Hansjorg, Ross, Douglas T, Soni, Raj, Chen, Yi, Guo, Hongshi, Howorth, Pamela, Valentine, Heather, Liang, Shi, Spicer, Dawn, Fuller, Mike, Steiner, Joseph P

“…The recent discovery that small molecule ligands for the peptidyl−prolyl isomerase (PPIase) FKBP12 possess powerful neuroprotective and neuroregenerative…”
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Synthesis and Biological Evaluation of Non-Peptidic Cyclophilin Ligands by Wu, Yong-Qian, Belyakov, Sergei, Choi, Chi, Limburg, David, Thomas, Vaal, Mark, Wei, Ling, Wilkinson, Douglas E, Holmes, Agnes, Fuller, Mike, McCormick, Jocelyn, Connolly, Maureen, Moeller, Tim, Steiner, Joseph, Hamilton, Gregory S

“…Peptidylprolyl isomerase cyclophilins play critical roles in a variety of biological processes. Recent findings that cyclophilins are present at high levels in…”
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Regeneration of Dopaminergic Function in 6-Hydroxydopamine-Lesioned Rats by Neuroimmunophilin Ligand Treatment by Zhang, Chunyi, Steiner, Joseph P, Hamilton, Gregory S, Hicks, T. Phillip, Poulter, Michael O

“…Nonimmunosuppressant immunophilin ligands have been found previously to stimulate neurite growth in culture and to promote regeneration of peripheral and…”
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Synthesis, molecular modeling and biological evaluation of aza-proline and aza-pipecolic derivatives as FKBP12 ligands and their in vivo neuroprotective effects by Wilkinson, Douglas E, Thomas, Bert E, Limburg, David C, Holmes, Agnes, Sauer, Hansjorg, Ross, Douglas T, Soni, Raj, Chen, Yi, Guo, Hong, Howorth, Pamela, Valentine, Heather, Spicer, Dawn, Fuller, Mike, Steiner, Joseph P, Hamilton, Gregory S, Wu, Yong-Qian

“…Nonimmunosuppressant ligands, exemplified by GPI 1046 ( 1), for the peptidyl-prolyl isomerase FKBP12 have been found to unexpectedly possess powerful…”
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The small molecule FKBP ligand GPI 1046 induces partial striatal re-innervation after intranigral 6-hydroxydopamine lesion in rats by Ross, Douglas T, Guo, Hongzhi, Howorth, Pamela, Chen, Yi, Hamilton, Gregory S, Steiner, Joseph P

“…Extensive unilateral striatal deafferentation was produced by intranigral 6-hydroxydopamine (6-OHDA) in rats. Beginning 60 days after 6-OHDA injection animals…”
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Formation of nitrogen-containing heterocycles using di(imidazole-1-yl)methanimine by Wu, Yong-Qian, Limburg, David C., Wilkinson, Douglas E., Hamilton, Gregory S.

“…A mild and efficient synthesis of five‐ and six‐membered nitrogen containing heterocyclic compounds, in which di(imidazole‐1‐yl)methanimine serves as a…”
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Systemic treatment with GPI 1046 improves spatial memory and reverses cholinergic neuron atrophy in the medial septal nucleus of aged mice by Sauer, Hansjörg, Francis, Jonathan M, Jiang, Hong, Hamilton, Gregory S, Steiner, Joseph P

“…Systemic treatment with GPI 1046, a non-immunosuppressive ligand of the immunophilin FKBP12 (FK-506-binding protein 12 kDa), has previously been shown to…”
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Synthesis and evaluation of chiral bicyclic proline FKBP12 ligands by LIMBURG, David C, THOMAS, Bert E, LI, Jia-He, FULLER, Mike, SPICER, Dawn, YI CHEN, HONGZHI GUO, STEINER, Joseph P, HAMILTON, Gregory S, WU, Yong-Qian

“…As part of our ongoing program to explore novel structural classes of FKBP12 ligands, we herein wish to report a new class of FKBP12 ligands containing chiral…”
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Synthesis of Ketone Analogues of Prolyl and Pipecolyl Ester FKBP12 Ligands by Wu, Yong-Qian, Wilkinson, Douglas E, Limburg, David, Li, Jia-He, Sauer, Hansjorg, Ross, Doug, Liang, Shi, Spicer, Dawn, Valentine, Heather, Fuller, Mike, Guo, Hong, Howorth, Pam, Soni, Raj, Chen, Yi, Steiner, Joseph P, Hamilton, Gregory S

“…The recently discovered small-molecule ligands for the peptidyl and prolyl isomerases (PPIase) of FKBP12 have been shown to possess powerful neuroprotective…”
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Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors by Choi, Chi, Li, Jia-He, Vaal, Mark, Thomas, Christine, Limburg, David, Wu, Yong-Qian, Chen, Yi, Soni, Raj, Scott, Chad, Ross, Douglas T, Guo, Hong, Howorth, Pamela, Valentine, Heather, Liang, Shi, Spicer, Dawn, Fuller, Mike, Steiner, Joseph, Hamilton, Gregory S

“…Using simple, inexpensive equipment, we have used solution-phase parallel synthesis to rapidly prepare hundreds of sulfonamide- and urea-containing FKBP…”
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