Search Results - "Hamilton, D A"

Behavioral flexibility in rats and mice: contributions of distinct frontocortical regions by Hamilton, D. A., Brigman, J. L.

“…Research examining the contribution of genetics to behavior is increasingly focused on higher order behavioral and cognitive processes including the ability to…”
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Antipsychotic drug effects in schizophrenia: a review of longitudinal FMRI investigations and neural interpretations by Abbott, C C, Jaramillo, A, Wilcox, C E, Hamilton, D A

“…The evidence that antipsychotics improve brain function and reduce symptoms in schizophrenia is unmistakable, but how antipsychotics change brain function is…”
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Medical professional involvement in smartphone 'apps' in dermatology by Hamilton, A.D., Brady, R.R.W.

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Selective Anion Binding by a Macrocycle with Convergent Hydrogen Bonding Functionality by Choi, Kihang, Hamilton, Andrew D

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The gelation of CO2 : A sustainable route to the creation of microcellular materials by SHI, C, HUANG, Z, KILIC, S, XU, J, ENICK, R. M, BECKMAN, E. J, CARR, A. J, MELENDEZ, R. E, HAMILTON, A. D

“…Compounds with strong thermodynamic affinity for carbon dioxide have been designed and synthesized that dissolve in CO2, then associate to form gels. Upon…”
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Toward Proteomimetics:  Terphenyl Derivatives as Structural and Functional Mimics of Extended Regions of an α-Helix by Orner, Brendan P, Ernst, Justin T, Hamilton, Andrew D

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Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter by DELARUE, F. L, ADNANE, J, CHELLAPPAN, S, SEBTI, S. M, JOSHI, B, BLASKOVICH, M. A, WANG, D.-A, HAWKER, J, BIZOUARN, F, OHKANDA, J, ZHU, K, HAMILTON, A. D

“…Recently, we have shown that RhoB suppresses EGFR-, ErbB2-, Ras- and Akt-mediated malignant transformation and metastasis. In this paper, we demonstrate that…”
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The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells by BOLICK, S. C. E, LANDOWSKIL, T. H, BOULWARE, D, OSHIRO, M. M, OHKANDA, J, HAMILTON, A. D, SEBTI, S. M, DALTON, W. S

“…Mutations of the ras gene are among the most commonly identified transforming events in human cancers, including multiple myeloma. Farnesyltransferase…”
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Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I : Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine by JIAZHI SUN, BLASKOVICH, M. A, KNOWLES, D, YIMIN QIAN, OHKANDA, J, BAILEY, R. D, HAMILTON, A. D, SEBTI, S. M

“…Ras malignant transformation requires posttranslational modification by farnesyltransferase (FTase). Here we report on the design and antitumor activity, in…”
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BCL2 gene abnormalities define distinct clinical subsets of follicular lymphoma by Goodlad, J R, Batstone, P J, Hamilton, D A, Kernohan, N M, Levison, D A, White, J M

“…Aims:  Follicular lymphoma (FL) arising primarily in the skin has recently been proposed as a distinct entity on the basis of a low incidence of…”
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Genetic responses to climate in Pinus contorta: niche breadth, climate change, and reforestation by Rehfeldt, Gerald E., Ying, Cheng C., Spittlehouse, David L., Hamilton, David A.

“…Fundamental plant-environment relationships were revealed by analyses of 20-yr height and survival of 118 populations representing two subspecies of Pinus…”
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Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts by SUN, J, YIMIN QIAN, HAMILTON, A. D, SEBTI, S. M

“…The ability of Ras oncoproteins to cause malignant transformation requires their post-translational modifications by prenyl groups. Because K-Ras can be both…”
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Thermodynamic Aspects of Dicarboxylate Recognition by Simple Artificial Receptors by Linton, Brian R, Goodman, M. Scott, Fan, Erkang, van Arman, Scott A, Hamilton, Andrew D

“…Recognition of dicarboxylates by bis-functional hydrogen-bonding receptors displays divergent thermodynamics in different solvent systems. NMR titration and…”
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Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines by LERNER, E. C, ZHANG, T.-T, KNOWLES, D. B, QIAN, Y, HAMILTON, A. D, SEBTI, S. M

“…The farnesyltransferase (FTase) inhibitor FTI-277 is highly effective at blocking oncogenic H-Ras but not K-Ras4B processing and signaling. While inhibition of…”
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Inhibiting ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes by BERNHARD, E. J, MCKENNA, W. G, HAMILTON, A. D, SEBTI, S. M, YIMIN QIAN, JUNMIN WU, MUSCHEL, R. J

“…The influence of activated ras oncogenes on the sensitivity of human tumor cells to killing by radiation has been an unresolved question in radiobiology. We…”
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The differential expression of a heat shock promoter in floral and reproductive tissues by Crone, D., Rueda, J., Martin, K. L., Hamilton, D. A., Mascarenhas, J. P.

“…A detailed histochemical analysis of the expression of the soybean small heat shock protein gene promoter, GmHSP 17·5E, fused to the GUS reporter gene, has…”
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Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion by JIAZHI SUN, YIMIN QIAN, HAMILTON, A. D, SEBTI, S. M

“…Farnesylation of the oncoprotein Ras is required for its cancer-causing activity. We have designed farnesyltransferase inhibitor (FTI)-276, a tetrapeptide…”
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The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts by BERNHARD, E. J, KAO, G, COX, A. D, SEBTI, S. M, HAMILTON, A. D, MUSCHEL, R. J, MCKENNA, W. G

“…Many tumor cells have a greater resistance to ionizing radiation than their normal counterparts, suggesting that the development of drugs that can reduce that…”
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Potent, Highly Selective, and Non-Thiol Inhibitors of Protein Geranylgeranyltransferase-I by Vasudevan, Anil, Qian, Yimin, Vogt, Andreas, Blaskovich, Michelle A, Ohkanda, Junko, Sebti, Said M, Hamilton, Andrew D

“…The design, synthesis, and biological evaluation of a family of peptidomimetic inhibitors of protein geranylgeranyltransferase-I (PGGTase-I) are reported. The…”
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Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues by Sebti, S M, Hamilton, A D

“…The fact that proteins such as Ras, Rac and RhoA require farnesylation or geranylgeranylation to induce malignant transformation prompted many investigators to…”
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