Search Results - "Hamilton, Alina M"

Reproducibility and intratumoral heterogeneity of the PAM50 breast cancer assay by Hurson, Amber N., Hamilton, Alina M., Olsson, Linnea T., Kirk, Erin L., Sherman, Mark E., Calhoun, Benjamin C., Geradts, Joseph, Troester, Melissa A.

“…Background The PAM50 assay is used routinely in clinical practice to determine breast cancer prognosis and management; however, research assessing how…”
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BIRC5 expression by race, age and clinical factors in breast cancer patients by Hamilton, Alina M, Walens, Andrea, Van Alsten, Sarah C, Olsson, Linnea T, Nsonwu-Farley, Joseph, Gao, Xiaohua, Kirk, Erin L, Perou, Charles M, Carey, Lisa A, Troester, Melissa A, Abdou, Yara

“…Survivin/BIRC5 is a proliferation marker that is associated with poor prognosis in breast cancer and an attractive therapeutic target. However, BIRC5 has not…”
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Hepatocyte growth factor pathway expression in breast cancer by race and subtype by Jones, Gieira S, Hoadley, Katherine A, Olsson, Linnea T, Hamilton, Alina M, Bhattacharya, Arjun, Kirk, Erin L, Tipaldos, Heather J, Fleming, Jodie M, Love, Michael I, Nichols, Hazel B, Olshan, Andrew F, Troester, Melissa A

“…African American women have the highest risk of breast cancer mortality compared to other racial groups. Differences in tumor characteristics have been…”
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Prognostic significance of RNA-based TP53 pathway function among estrogen receptor positive and negative breast cancer cases by Hurson, Amber N., Abubakar, Mustapha, Hamilton, Alina M., Conway, Kathleen, Hoadley, Katherine A., Love, Michael I., Olshan, Andrew F., Perou, Charles M., Garcia-Closas, Montserrat, Troester, Melissa A.

“…TP53 and estrogen receptor (ER) are essential in breast cancer development and progression, but TP53 status (by DNA sequencing or protein expression) has been…”
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An approach for normalization and quality control for NanoString RNA expression data by Bhattacharya, Arjun, Hamilton, Alina M, Furberg, Helena, Pietzak, Eugene, Purdue, Mark P, Troester, Melissa A, Hoadley, Katherine A, Love, Michael I

“…The NanoString RNA counting assay for formalin-fixed paraffin embedded samples is unique in its sensitivity, technical reproducibility and robustness for…”
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Race and Ancestry in Immune Response to Breast Cancer by Hamilton, Alina M, Hoadley, Katherine A, Troester, Melissa A

“…Martini and colleagues performed genetic ancestry estimation on a unique international triple-negative breast cancer (TNBC) study enriched for participants…”
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DeCompress: tissue compartment deconvolution of targeted mRNA expression panels using compressed sensing by Bhattacharya, Arjun, Hamilton, Alina M, Troester, Melissa A, Love, Michael I

“…Abstract Targeted mRNA expression panels, measuring up to 800 genes, are used in academic and clinical settings due to low cost and high sensitivity for…”
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Molecular Features of Cancers Exhibiting Exceptional Responses to Treatment by Wheeler, David A., Takebe, Naoko, Hinoue, Toshinori, Hoadley, Katherine A., Cardenas, Maria F., Hamilton, Alina M., Laird, Peter W., Wang, Linghua, Johnson, Adrienne, Dewal, Ninad, Miller, Vincent, Piñeyro, David, Castro de Moura, Manuel, Esteller, Manel, Shen, Hui, Zenklusen, Jean Claude, Tarnuzzer, Roy, McShane, Lisa M., Tricoli, James V., Williams, Paul M., Lubensky, Irina, O'Sullivan-Coyne, Geraldine, Kohn, Elise C., Little, Richard F., White, Jeffrey, Malik, Shakun, Harris, Lyndsay, Weil, Carol, Chen, Alice P., Karlovich, Chris, Rodgers, Brian, Shankar, Lalitha, Jacobs, Paula, Nolan, Tracy, Hu, Jianhong, Muzny, Donna M., Doddapaneni, Harshavardhan, Korchina, Viktoriya, Gastier-Foster, Julie, Bowen, Jay, Leraas, Kristen, Edmondson, Elijah F., Doroshow, James H., Conley, Barbara A., Ivy, S. Percy, Staudt, Louis M.

“…A small fraction of cancer patients with advanced disease survive significantly longer than patients with clinically comparable tumors. Molecular mechanisms…”
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Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer by Pingili, Ajeeth K., Chaib, Mehdi, Sipe, Laura M., Miller, Emily J., Teng, Bin, Sharma, Rahul, Yarbro, Johnathan R., Asemota, Sarah, Al Abdallah, Qusai, Mims, Tahliyah S., Marion, Tony N., Daria, Deidre, Sekhri, Radhika, Hamilton, Alina M., Troester, Melissa A., Jo, Heejoon, Choi, Hyo Young, Hayes, D. Neil, Cook, Katherine L., Narayanan, Ramesh, Pierre, Joseph F., Makowski, Liza

“…Immune checkpoint blockade (ICB) has improved outcomes in some cancers. A major limitation of ICB is that most patients fail to respond, which is partly…”
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Associations of prostate tumor immune landscape with vigorous physical activity and prostate cancer progression by Huang, Lanshan, Winter, Sarah J, Olsson, Linnea T, Hamilton, Alina M, Halliday, Sophia R, Kirk, Erin L, Farnan, Laura, Gerstel, Adrian, Craig, Stephanie G, Finn, Stephen P, LaBonte Wilson, Melissa, Jain, Suneil, Troester, Melissa A, Butler, Eboneé N, Bensen, Jeannette T, Wobker, Sara E, Allott, Emma H

“…Vigorous physical activity has been associated with lower risk of fatal prostate cancer. However, mechanisms contributing to this relationship are not…”
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Patterns of chemotherapy receipt among patients with hormone receptor-positive, HER2-negative breast cancer by Olsson, Linnea T., Hamilton, Alina M., Van Alsten, Sarah C., Lund, Jennifer L., Stürmer, Til, Nichols, Hazel B., Reeder-Hayes, Katherine E., Troester, Melissa A.

“…Background Breast cancer chemotherapy utilization not only may differ by race and age, but also varies by genomic risk, tumor characteristics, and patient…”
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The Landscape of Immune Microenvironments in Racially Diverse Breast Cancer Patients by Hamilton, Alina M, Hurson, Amber N, Olsson, Linnea T, Walens, Andrea, Nsonwu-Farley, Joseph, Kirk, Erin L, Abdou, Yara, Downs-Canner, Stephanie M, Serody, Jonathan S, Perou, Charles M, Calhoun, Benjamin C, Troester, Melissa A, Hoadley, Katherine A

“…Immunotherapy is a rapidly evolving treatment option in breast cancer; However, the breast cancer immune microenvironment is understudied in Black and younger…”
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RNA-Based Classification of Homologous Recombination Deficiency in Racially Diverse Patients with Breast Cancer by Walens, Andrea, Van Alsten, Sarah C, Olsson, Linnea T, Smith, Markia A, Lockhart, Alex, Gao, Xiaohua, Hamilton, Alina M, Kirk, Erin L, Love, Michael I, Gupta, Gaorav P, Perou, Charles M, Vaziri, Cyrus, Hoadley, Katherine A, Troester, Melissa A

“…Aberrant expression of DNA repair pathways such as homologous recombination (HR) can lead to DNA repair imbalance, genomic instability, and altered…”
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Spatial Characterization of Tumor-Infiltrating Lymphocytes and Breast Cancer Progression by Fassler, Danielle J, Torre-Healy, Luke A, Gupta, Rajarsi, Hamilton, Alina M, Kobayashi, Soma, Van Alsten, Sarah C, Zhang, Yuwei, Kurc, Tahsin, Moffitt, Richard A, Troester, Melissa A, Hoadley, Katherine A, Saltz, Joel

“…Tumor-infiltrating lymphocytes (TILs) have been established as a robust prognostic biomarker in breast cancer, with emerging utility in predicting treatment…”
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Obesity and Breast Cancer Metastasis across Genomic Subtypes by Olsson, Linnea T, Walens, Andrea, Hamilton, Alina M, Benefield, Halei C, Fleming, Jodie M, Carey, Lisa A, Hursting, Stephen D, Williams, Kevin P, Troester, Melissa A

“…Obese women have higher risk of aggressive breast tumors and distant metastasis. However, obesity has rarely been assessed in association with metastasis in…”
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Disparities in OncotypeDx Testing and Subsequent Chemotherapy Receipt by Geography and Socioeconomic Status by Van Alsten, Sarah C, Dunn, Matthew R, Hamilton, Alina M, Ivory, Joannie M, Gao, Xiaohua, Kirk, Erin L, Nsonwu-Farley, Joseph S, Carey, Lisa A, Abdou, Yara, Reeder-Hayes, Katherine E, Roberson, Mya L, Wheeler, Stephanie B, Emerson, Marc A, Hyslop, Terry, Troester, Melissa A

“…OncotypeDx is a prognostic and predictive genomic assay used in early-stage hormone receptor-positive, HER2- (HR+/HER2-) breast cancer. It is used to inform…”
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Molecular and Clinical Characterization of Postpartum-Associated Breast Cancer in the Carolina Breast Cancer Study Phase I-III, 1993-2013 by Vohra, Sanah N, Walens, Andrea, Hamilton, Alina M, Sherman, Mark E, Schedin, Pepper, Nichols, Hazel B, Reeder-Hayes, Katherine E, Olshan, Andrew F, Love, Michael I, Troester, Melissa A

“…Breast cancers in recently postpartum women may have worse outcomes, but studies examining tumor molecular features by pregnancy recency have shown conflicting…”
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TP53 Pathway Function, Estrogen Receptor Status, and Breast Cancer Risk Factors in the Carolina Breast Cancer Study by Hurson, Amber N, Abubakar, Mustapha, Hamilton, Alina M, Conway, Kathleen, Hoadley, Katherine A, Love, Michael I, Olshan, Andrew F, Perou, Charles M, Garcia-Closas, Montserrat, Troester, Melissa A

“…TP53 and estrogen receptor (ER) both play essential roles in breast cancer development and progression, with recent research revealing cross-talk between TP53…”
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Protein-based immune profiles of basal-like vs. luminal breast cancers by Walens, Andrea, Olsson, Linnea T., Gao, Xiaohua, Hamilton, Alina M., Kirk, Erin L., Cohen, Stephanie M., Midkiff, Bentley R., Xia, Yongjuan, Sherman, Mark E., Nikolaishvili-Feinberg, Nana, Serody, Jonathan S., Hoadley, Katherine A., Troester, Melissa A., Calhoun, Benjamin C.

“…Tumor-infiltrating lymphocytes play an important, but incompletely understood role in chemotherapy response and prognosis. In breast cancer, there appear to be…”
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Epithelial p53 Status Modifies Stromal-Epithelial Interactions During Basal-Like Breast Carcinogenesis by Fuller, Ashley M., Yang, Lin, Hamilton, Alina M., Pirone, Jason R., Oldenburg, Amy L., Troester, Melissa A.

“…Basal-like breast cancers (BBC) exhibit subtype-specific phenotypic and transcriptional responses to stroma, but little research has addressed how…”
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