Search Results - "Hamik, Anne"

Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice by Zhou, Guangjin, Hamik, Anne, Nayak, Lalitha, Tian, Hongmei, Shi, Hong, Lu, Yuan, Sharma, Nikunj, Liao, Xudong, Hale, Andrew, Boerboom, Lauren, Feaver, Ryan E, Gao, Huiyun, Desai, Amar, Schmaier, Alvin, Gerson, Stanton L, Wang, Yunmei, Atkins, G Brandon, Blackman, Brett R, Simon, Daniel I, Jain, Mukesh K

“…The endothelium regulates vascular homeostasis, and endothelial dysfunction is a proximate event in the pathogenesis of atherothrombosis. Stimulation of the…”
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A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction by Hsieh, Paishiun N., Zhou, Guangjin, Yuan, Yiyuan, Zhang, Rongli, Prosdocimo, Domenick A., Sangwung, Panjamaporn, Borton, Anna H., Boriushkin, Evgenii, Hamik, Anne, Fujioka, Hisashi, Fealy, Ciaran E., Kirwan, John P., Peters, Maureen, Lu, Yuan, Liao, Xudong, Ramírez-Bergeron, Diana, Feng, Zhaoyang, Jain, Mukesh K.

“…Loss of protein and organelle quality control secondary to reduced autophagy is a hallmark of aging. However, the physiologic and molecular regulation of…”
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ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4 by Choi, Dongwon, Park, Eunkyung, Jung, Eunson, Seong, Young Jin, Hong, Mingu, Lee, Sunju, Burford, James, Gyarmati, Georgina, Peti-Peterdi, Janos, Srikanth, Sonal, Gwack, Yousang, Koh, Chester J, Boriushkin, Evgenii, Hamik, Anne, Wong, Alex K, Hong, Young-Kwon

“…RATIONALE:Lymphatic vessels function to drain interstitial fluid from a variety of tissues. Although shear stress generated by fluid flow is known to trigger…”
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Streptococcus oralis MitraClip endocarditis following a dental procedure: a case report by Papamanoli, Aikaterini, Rahman, Tahmid, Kalogeropoulos, Andreas P, Lobo, Zeena, Diggs, Paul, Hamik, Anne, Psevdos, George

“…Abstract Background Transcatheter edge-to-edge mitral valve repair using the MitraClip device is increasingly used for high surgical risk patients with severe…”
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Endothelial Krüppel-like Factor 4 Regulates Angiogenesis and the Notch Signaling Pathway by Hale, Andrew T., Tian, Hongmei, Anih, Ejike, Recio, Fernando O., Shatat, Mohammad A., Johnson, Trent, Liao, Xudong, Ramirez-Bergeron, Diana L., Proweller, Aaron, Ishikawa, Masakazu, Hamik, Anne

“…Regulation of endothelial cell biology by the Notch signaling pathway (Notch) is essential to vascular development, homeostasis, and sprouting angiogenesis…”
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Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells by SEN-BANERJEE, Sucharita, MIR, Samy, ZHIYONG LIN, HAMIK, Anne, ATKINS, G. Brandon, DAS, Hiranmoy, BANERJEE, Pallab, KUMAR, Ajay, JAIN, Mukesh K

“…Although 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are known to modulate endothelial function, the transcriptional mechanisms…”
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Inhibition of Vascular Permeability Factor/Vascular Endothelial Growth Factor-mediated Angiogenesis by the Kruppel-like Factor KLF2 by Bhattacharya, Resham, SenBanerjee, Sucharita, Lin, Zhiyong, Mir, Samy, Hamik, Anne, Wang, Ping, Mukherjee, Priyabrata, Mukhopadhyay, Debabrata, Jain, Mukesh K.

“…The Kruppel-like factor KLF2 was recently identified as a novel regulator of endothelial pro-inflammatory and pro-thrombotic function. Here it is shown that…”
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Kruppel-like Factor 4 Regulates Endothelial Inflammation by Hamik, Anne, Lin, Zhiyong, Kumar, Ajay, Balcells, Mercedes, Sinha, Sumita, Katz, Jonathan, Feinberg, Mark W., Gerszten, Robert E., Edelman, Elazer R., Jain, Mukesh K.

“…The vascular endothelium plays a critical role in vascular homeostasis. Inflammatory cytokines and non-laminar blood flow induce endothelial dysfunction and…”
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Endothelial Grb2-Associated Binder 1 Is Crucial for Postnatal Angiogenesis by Zhao, Jinjing, Wang, Weiye, Ha, Chang Hoon, Kim, Ji Young, Wong, Chelsea, Redmond, Eileen M, Hamik, Anne, Jain, Mukesh K, Feng, Gen-Sheng, Jin, Zheng Gen

“…OBJECTIVE—Grb2-associated binder 1 (Gab1), a scaffolding adaptor protein, plays an important role in transmitting key signals that control cell growth,…”
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Kruppel-Like Factor 2 Inhibits Protease Activated Receptor-1 Expression and Thrombin-Mediated Endothelial Activation by Lin, Zhiyong, Hamik, Anne, Jain, Rajan, Kumar, Ajay, Jain, Mukesh K

“…OBJECTIVE—The serine protease thrombin can dramatically alter endothelial gene expression in a manner that confers a proinflammatory phenotype. Recent studies…”
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A novel role of CCN3 in regulating endothelial inflammation by Lin, Zhiyong, Natesan, Viswanath, Shi, Hong, Hamik, Anne, Kawanami, Daiji, Hao, Caili, Mahabaleshwar, Ganapati H., Wang, Weiye, Jin, Zheng-Gen, Atkins, G. Brandon, Firth, Sue M., Rittié, Laure, Perbal, Bernard, Jain, Mukesh K.

“…The vascular endothelium plays a fundamental role in the health and disease of the cardiovascular system. The molecular mechanisms regulating endothelial…”
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Down-regulation of Monocyte Tissue Factor Mediated by Tissue Factor Pathway Inhibitor and the Low Density Lipoprotein Receptor-related Protein by Hamik, A, Setiadi, H, Bu, G, McEver, R P, Morrissey, J H

“…Inflammatory mediators like bacterial lipopolysaccharide induce monocytes to express tissue factor (TF), the cell-surface protein that triggers the blood…”
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Regulation of an Inflammatory Disease: Krüppel-Like Factors and Atherosclerosis by Jain, Mukesh K, Sangwung, Panjamaporn, Hamik, Anne

“…This invited review summarizes work presented in the Russell Ross lecture delivered at the 2012 proceedings of the American Heart Association. We begin with a…”
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Krüppel-like factor 4 regulates macrophage polarization by Liao, Xudong, Sharma, Nikunj, Kapadia, Fehmida, Zhou, Guangjin, Lu, Yuan, Hong, Hong, Paruchuri, Kaavya, Mahabeleshwar, Ganapati H, Dalmas, Elise, Venteclef, Nicolas, Flask, Chris A, Kim, Julian, Doreian, Bryan W, Lu, Kurt Q, Kaestner, Klaus H, Hamik, Anne, Clément, Karine, Jain, Mukesh K

“…Current paradigms suggest that two macrophage subsets, termed M1 and M2, are involved in inflammation and host defense. While the distinct functions of M1 and…”
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Endothelial Differentiation: Molecular Mechanisms of Specification and Heterogeneity by Atkins, G Brandon, Jain, Mukesh K, Hamik, Anne

“…A complex and diverse vascular system is requisite for the survival of higher organisms. The process of vascular development is highly regulated, involving the…”
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Kruppel-like factor 4 regulates developmental angiogenesis through disruption of the RBP-J–NICD–MAML complex in intron 3 of Dll4 by Boriushkin, Evgenii, Zhang, Hui, Becker, Mitchell, Peachey, Janet, Shatat, Mohammad A., Adams, Ralf H., Hamik, Anne

“…Angiogenesis is a multistep process that requires highly regulated endothelial cell (EC) behavior. The transcription factor Krüppel-like factor 4 (KLF4) is a…”
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Cardiorespiratory Fitness and Atherosclerosis: Recent Data and Future Directions by Mehanna, Emile, Hamik, Anne, Josephson, Richard A

“…Historically, the relationship between exercise and the cardiovascular system was viewed as unidirectional, with a disease resulting in exercise limitation and…”
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Endothelial cell activation by antiphospholipid antibodies is modulated by Krüppel-like transcription factors by Allen, Kristi L., Hamik, Anne, Jain, Mukesh K., McCrae, Keith R.

“…Antiphospholipid syndrome is characterized by thrombosis and/or recurrent pregnancy loss in the presence of antiphospholipid antibodies (APLAs). The majority…”
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MiRrored Regulation of KLF2 and KLF4 by Hamik, Anne, Jain, Mukesh K

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Endothelial Krüppel-like factor 4 modulates pulmonary arterial hypertension by Shatat, Mohammad A, Tian, Hongmei, Zhang, Rongli, Tandon, Gaurav, Hale, Andrew, Fritz, Jason S, Zhou, Guangjin, Martínez-González, José, Rodríguez, Cristina, Champion, Hunter C, Jain, Mukesh K, Hamik, Anne

“…Krüppel-like factor 4 (KLF4) is a transcription factor expressed in the vascular endothelium, where it promotes anti-inflammatory and anticoagulant states, and…”
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