Search Results - "Hamerman, Jessica A."

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19 by Rodda, Lauren B., Netland, Jason, Shehata, Laila, Pruner, Kurt B., Morawski, Peter A., Thouvenel, Christopher D., Takehara, Kennidy K., Eggenberger, Julie, Hemann, Emily A., Waterman, Hayley R., Fahning, Mitchell L., Chen, Yu, Hale, Malika, Rathe, Jennifer, Stokes, Caleb, Wrenn, Samuel, Fiala, Brooke, Carter, Lauren, Hamerman, Jessica A., King, Neil P., Gale, Michael, Campbell, Daniel J., Rawlings, David J., Pepper, Marion

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is causing a global pandemic, and cases continue to rise. Most infected individuals…”
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TREM‐2, triggering receptor expressed on myeloid cell‐2, negatively regulates TLR responses in dendritic cells by Ito, Hiroaki, Hamerman, Jessica A.

“…DCs play a key role in defense against infections and also in preventing inflammatory and autoimmune diseases. The response of DCs to pathogens is tightly…”
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Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes by Akilesh, Holly M, Buechler, Matthew B, Duggan, Jeffrey M, Hahn, William O, Matta, Bharati, Sun, Xizhang, Gessay, Griffin, Whalen, Elizabeth, Mason, Michael, Presnell, Scott R, Elkon, Keith B, Lacy-Hulbert, Adam, Barnes, Betsy J, Pepper, Marion, Hamerman, Jessica A

“…Cytopenias are an important clinical problem associated with inflammatory disease and infection. We show that specialized phagocytes that internalize red blood…”
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Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells by Baharom, Faezzah, Ramirez-Valdez, Ramiro A., Tobin, Kennedy K. S., Yamane, Hidehiro, Dutertre, Charles-Antoine, Khalilnezhad, Ahad, Reynoso, Glennys V., Coble, Vincent L., Lynn, Geoffrey M., Mulè, Matthew P., Martins, Andrew J., Finnigan, John P., Zhang, Xiao Meng, Hamerman, Jessica A., Bhardwaj, Nina, Tsang, John S., Hickman, Heather D., Ginhoux, Florent, Ishizuka, Andrew S., Seder, Robert A.

“…Personalized cancer vaccines are a promising approach for inducing T cell immunity to tumor neoantigens. Using a self-assembling nanoparticle vaccine that…”
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Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases by Hamerman, Jessica A., Pottle, Jessica, Ni, Minjian, He, Yantao, Zhang, Zhong-Yin, Buckner, Jane H.

“…Summary Toll‐like receptors (TLR) are transmembrane pattern recognition receptors that recognize microbial ligands and signal for production of inflammatory…”
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Mediators of monocyte chemotaxis and matrix remodeling are associated with mortality and pulmonary fibroproliferation in patients with severe COVID-19 by Holton, Sarah E, Mitchem, Mallorie, Chalian, Hamid, Pipavath, Sudhakar, Morrell, Eric D, Bhatraju, Pavan K, Hamerman, Jessica A, Speake, Cate, Malhotra, Uma, Wurfel, Mark M, Ziegler, Steven E, Mikacenic, Carmen

“…Acute respiratory distress syndrome (ARDS) has a fibroproliferative phase that may be followed by pulmonary fibrosis. Pulmonary fibrosis following COVID-19…”
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TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria by N'Diaye, Elsa-Noah, Branda, Catherine S, Branda, Steven S, Nevarez, Lisette, Colonna, Marco, Lowell, Clifford, Hamerman, Jessica A, Seaman, William E

“…Phagocytosis, which is essential for the immune response to pathogens, is initiated by specific interactions between pathogens and cell surface receptors…”
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Endotracheal aspirates contain a limited number of lower respiratory tract immune cells by Orlov, Marika, Morrell, Eric D, Dmyterko, Victoria, Hamerman, Jessica A, Wurfel, Mark M, Mikacenic, Carmen

“…[...]there is a paucity of information regarding whether ETAs are a reasonable surrogate for bronchoalveolar lavage (BAL) to study lung specific immune…”
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Cutting Edge: Inhibition of TLR and FcR Responses in Macrophages by Triggering Receptor Expressed on Myeloid Cells (TREM)-2 and DAP12 by Hamerman, Jessica A, Jarjoura, Jessica R, Humphrey, Mary Beth, Nakamura, Mary C, Seaman, William E, Lanier, Lewis L

“…DAP12 is an ITAM-containing adapter that associates with receptors in myeloid and NK cells. DAP12-associated receptors can give activation signals leading to…”
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Cutting edge: Type I IFN drives emergency myelopoiesis and peripheral myeloid expansion during chronic TLR7 signaling by Buechler, Matthew B, Teal, Thomas H, Elkon, Keith B, Hamerman, Jessica A

“…Mice overexpressing TLR7 (TLR7.1 mice) are a model of systemic lupus erythematosus pathogenesis and exhibit peripheral myeloid expansion. We show that TLR7.1…”
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Tracing Conidial Fate and Measuring Host Cell Antifungal Activity Using a Reporter of Microbial Viability in the Lung by Jhingran, Anupam, Mar, Katrina B., Kumasaka, Debra K., Knoblaugh, Sue E., Ngo, Lisa Y., Segal, Brahm H., Iwakura, Yoichiro, Lowell, Clifford A., Hamerman, Jessica A., Lin, Xin, Hohl, Tobias M.

“…Fluorescence can be harnessed to monitor microbial fate and to investigate functional outcomes of individual microbial cell-host cell encounters at portals of…”
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Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells by Giltiay, Natalia V, Chappell, Craig P, Sun, Xizhang, Kolhatkar, Nikita, Teal, Thomas H, Wiedeman, Alice E, Kim, Jinoh, Tanaka, Lena, Buechler, Matthew B, Hamerman, Jessica A, Imanishi-Kari, Thereza, Clark, Edward A, Elkon, Keith B

“…Toll-like receptor (TLR), a ligand for single-stranded RNA, has been implicated in the development of pathogenic anti-RNA autoantibodies both in systemic lupus…”
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TLR-2/TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney injury by Campanholle, Gabriela, Mittelsteadt, Kristen, Nakagawa, Shunsaku, Kobayashi, Akio, Lin, Shuei-Liong, Gharib, Sina A, Heinecke, Jay W, Hamerman, Jessica A, Altemeier, William A, Duffield, Jeremy S

“…Inflammatory macrophages are abundant in kidney disease, stimulating repair, or driving chronic inflammation and fibrosis. Damage associated molecules (DAMPs),…”
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Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12 by Lanier, Lewis L, Hamerman, Jessica A, Tchao, Nadia K, Lowell, Clifford A

“…DAP12 is a signaling adaptor containing an immunoreceptor tyrosine-based activation motif (ITAM) that pairs with receptors on myeloid cells and natural killer…”
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B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K by Ni, Minjian, MacFarlane, Alexander W., Toft, Michelle, Lowell, Clifford A., Campbell, Kerry S., Hamerman, Jessica A.

“…Toll-like receptors (TLRs) recognize pathogens and their components, thereby initiating immune responses to infectious organisms. TLR ligation leads to the…”
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Cutting Edge: Toll-Like Receptor Signaling in Macrophages Induces Ligands for the NKG2D Receptor by Hamerman, Jessica A, Ogasawara, Kouetsu, Lanier, Lewis L

“…Macrophages recognize the presence of infection by using the Toll-like receptor (TLR) family of proteins that detect ligands on bacterial, viral, and fungal…”
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The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages by Tampella, Giacomo, Kerns, Hannah M, Niu, Deqiang, Singh, Swati, Khim, Socheath, Bosch, Katherine A, Garrett, Meghan E, Moguche, Albanus, Evans, Erica, Browning, Beth, Jahan, Tahmina A, Nacht, Mariana, Wolf-Yadlin, Alejandro, Plebani, Alessandro, Hamerman, Jessica A, Rawlings, David J, James, Richard G

“…Previous work has shown conflicting roles for Tec family kinases in regulation of TLR-dependent signaling in myeloid cells. In the present study, we performed…”
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NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules by Lodoen, Melissa, Ogasawara, Kouetsu, Hamerman, Jessica A, Arase, Hisashi, Houchins, Jeffrey P, Mocarski, Edward S, Lanier, Lewis L

“…Natural killer (NK) cells play a critical role in the innate immune response against cytomegalovirus (CMV) infections. Although CMV encodes several gene…”
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The Activating Immunoreceptor NKG2D and Its Ligands Are Involved in Allograft Transplant Rejection by Kim, Jim, Chang, Catherine K, Hayden, Tracy, Liu, Feng-Chun, Benjamin, Jonathan, Hamerman, Jessica A, Lanier, Lewis L, Kang, Sang-Mo

“…Although the linkage between innate and adaptive immunity in transplantation has been recognized, the mechanisms underlying this cooperation remain to be fully…”
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cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses by Hahn, William O, Butler, Noah S, Lindner, Scott E, Akilesh, Holly M, Sather, D Noah, Kappe, Stefan Hi, Hamerman, Jessica A, Gale, Jr, Michael, Liles, W Conrad, Pepper, Marion

“…Sensing of pathogens by host pattern recognition receptors is essential for activating the immune response during infection. We used a nonlethal murine model…”
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