Search Results - "Hamerlik, P."

Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells by Venere, M, Hamerlik, P, Wu, Q, Rasmussen, R D, Song, L A, Vasanji, A, Tenley, N, Flavahan, W A, Hjelmeland, A B, Bartek, J, Rich, J N

“…Glioblastoma-initiating cells (GICs) are self-renewing tumorigenic sub-populations, contributing to therapeutic resistance via decreased sensitivity to…”
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Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas by Bartkova, J, Hamerlik, P, Stockhausen, M-T, Ehrmann, J, Hlobilkova, A, Laursen, H, Kalita, O, Kolar, Z, Poulsen, H S, Broholm, H, Lukas, J, Bartek, J

“…Malignant gliomas, the deadliest of brain neoplasms, show rampant genetic instability and resistance to genotoxic therapies, implicating potentially aberrant…”
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Cytomegalovirus infection induces a stem cell phenotype in human primary glioblastoma cells: prognostic significance and biological impact by Fornara, O, Bartek Jr, J, Rahbar, A, Odeberg, J, Khan, Z, Peredo, I, Hamerlik, P, Bartek, J, Stragliotto, G, Landázuri, N, Söderberg-Nauclér, C

“…Glioblastoma (GBM) is associated with poor prognosis despite aggressive surgical resection, chemotherapy, and radiation therapy. Unfortunately, this standard…”
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Early indicators of primary brain tumours: a population‐based study with 10 years’ follow‐up by Marku, M., Rasmussen, B. K., Dalton, S. O., Johansen, C., Hamerlik, P., Andersen, K. K., Meier, S. M., Bidstrup, P. E.

“…Background and purpose To improve diagnoses of primary brain tumours, knowledge about early indicators is needed. Nationwide Danish health registries were used…”
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Acquisition of meiotic DNA repair regulators maintain genome stability in glioblastoma by Rivera, M, Wu, Q, Hamerlik, P, Hjelmeland, A B, Bao, S, Rich, J N

“…Glioblastoma (GBM), the most prevalent type of primary intrinsic brain cancer in adults, remains universally fatal despite maximal therapy, including…”
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P02.05.B Targeted therapies of Glioblastoma using single cell sequencing and drug-response analysis in a phase 2 clinical trial setting by Lü, M, Hendriksen, J, Urup, T, Hamerlik, P, Wennerberg, K, Lassen, U, Skovgaard, H, Weischenfeldt, J

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P26.03.B AN INTERNATIONAL ACCELERATOR PROGRAMME FOR NOVEL BRAIN TUMOUR THERAPIES by Aitken, C K, Huskens, N, Bushby, K, Noble, K, Hamerlik, P, Kobayashi, D, Mathew, R, McCall, J, Plummer, R, Rahman, R, Lopez, J

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AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity by Maiani, Emiliano, Milletti, Giacomo, Nazio, Francesca, Holdgaard, Søs Grønbæk, Bartkova, Jirina, Rizza, Salvatore, Cianfanelli, Valentina, Lorente, Mar, Simoneschi, Daniele, Di Marco, Miriam, D’Acunzo, Pasquale, Di Leo, Luca, Rasmussen, Rikke, Montagna, Costanza, Raciti, Marilena, De Stefanis, Cristiano, Gabicagogeascoa, Estibaliz, Rona, Gergely, Salvador, Nélida, Pupo, Emanuela, Merchut-Maya, Joanna Maria, Daniel, Colin J., Carinci, Marianna, Cesarini, Valeriana, O’sullivan, Alfie, Jeong, Yeon-Tae, Bordi, Matteo, Russo, Francesco, Campello, Silvia, Gallo, Angela, Filomeni, Giuseppe, Lanzetti, Letizia, Sears, Rosalie C., Hamerlik, Petra, Bartolazzi, Armando, Hynds, Robert E., Pearce, David R., Swanton, Charles, Pagano, Michele, Velasco, Guillermo, Papaleo, Elena, De Zio, Daniela, Maya-Mendoza, Apolinar, Locatelli, Franco, Bartek, Jiri, Cecconi, Francesco

“…Mammalian development, adult tissue homeostasis and the avoidance of severe diseases including cancer require a properly orchestrated cell cycle, as well as…”
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Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth by Hamerlik, Petra, Lathia, Justin D, Rasmussen, Rikke, Wu, Qiulian, Bartkova, Jirina, Lee, MyungHee, Moudry, Pavel, Bartek, Jr, Jiri, Fischer, Walter, Lukas, Jiri, Rich, Jeremy N, Bartek, Jiri

“…Although vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) is traditionally regarded as an endothelial cell protein, evidence suggests that VEGFRs…”
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BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity by Rasmussen, Rikke D., Gajjar, Madhavsai K., Tuckova, Lucie, Jensen, Kamilla E., Maya-Mendoza, Apolinar, Holst, Camilla B., Møllgaard, Kjeld, Rasmussen, Jane S., Brennum, Jannick, Bartek, Jiri, Syrucek, Martin, Sedlakova, Eva, Andersen, Klaus K., Frederiksen, Marie H., Bartek, Jiri, Hamerlik, Petra

“…Oncogene-evoked replication stress (RS) fuels genomic instability in diverse cancer types. Here we report that BRCA1, traditionally regarded a tumour…”
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P01.05.A DRUG-RESPONSE ANALYSIS AND SINGLE NUCLEUS RNA SEQUENCING ON PATIENT-DERIVED NEUROSPHERES TO REVEAL DRUG RESPONSE AND RESISTANCE MECHANISMS IN GLIOBLASTOMA by Lü, M J S, Hendriksen, J D, Ariey-Bonnet, J, Anand, A, Michaelsen, S R, González, F G R, Locallo, A, Azam, A, Skjøth-Rasmussen, J, Hamerlik, P, Nørøxe, D S, Hasselbalch, B, Vik-Mo, E, Kristensen, B W, Urup, T, Lassen, U, Poulsen, H S, Wennerberg, K, Weischenfeldt, J

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Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1 by Staniszewska, Anna D, Pilger, Domenic, Gill, Sonja J, Jamal, Kunzah, Bohin, Natacha, Guzzetti, Sofia, Gordon, Jacob, Hamm, Gregory, Mundin, Gill, Illuzzi, Giuditta, Pike, Andy, McWilliams, Lisa, Maglennon, Gareth, Rose, Jonathan, Hawthorne, Glen, Cortes Gonzalez, Miguel, Halldin, Christer, Johnström, Peter, Schou, Magnus, Critchlow, Susan E, Fawell, Stephen, Johannes, Jeffrey W, Leo, Elisabetta, Davies, Barry R, Cosulich, Sabina, Sarkaria, Jann N, O'Connor, Mark J, Hamerlik, Petra

“…We evaluated the properties and activity of AZD9574, a blood-brain barrier (BBB) penetrant selective inhibitor of PARP1, and assessed its efficacy and safety…”
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SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells by Obara, Elisabeth Anne Adanma, Aguilar-Morante, Diana, Rasmussen, Rikke Darling, Frias, Alex, Vitting-Serup, Kristoffer, Lim, Yi Chieh, Elbæk, Kirstine Juul, Pedersen, Henriette, Vardouli, Lina, Jensen, Kamilla Ellermann, Skjoth-Rasmussen, Jane, Brennum, Jannick, Tuckova, Lucie, Strauss, Robert, Dinant, Christoffel, Bartek, Jiri, Hamerlik, Petra

“…Glioblastoma cancer-stem like cells (GSCs) display marked resistance to ionizing radiation (IR), a standard of care for glioblastoma patients. Mechanisms…”
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P08.18 Replication stress as a driver of genomic instability in malignant gliomas by Rasmussen, R., Gajjar, M., Tuckova, L., Jensen, K., Maya-Mendoza, A., Bartek, J., Hamerlik, P.

“…Glioblastoma (GBM, WHO grade IV astrocytoma) is among the deadliest of solid tumors with median survival rates of only approximately 15 months. In spite of…”
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SP-0450: Replication stress as a driver of genomic instability in malignant gliomas by Hamerlik, P., Rikke Darling Rasmussen, R., Elisabeth, E., Obara, A., Kamilla, K., Jensen, E., Diana, D., Morante, A., Alex, A., Hernandez, F., Christoffel Dinant, C., Jiri Bartek, J.

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P01.12 VEGF-C contributes to autocrine VEGF Receptor 2 signaling and cellular maintenance in Glioblastoma by Michaelsen, S. R., Nedergaard, M. K., Broholm, H., Bartkova, J., Staberg, M., Aghi, M., Lucacova, S., Perryman, L., Poulsen, H. S., Hamerlik, P.

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P08.06 Transcriptional changes induced by bevacizumab combination therapy in responding and non-responding recurrent glioblastoma patients by Urup, T., Staunstrup, L., Michaelsen, S., Vitting-Seerup, K., Bennedbæk, M., Toft, A., Broholm, H., Hamerlik, P., Poulsen, H., Lassen, U.

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First imaging of PARP1 in the living human brain - a translational PET study with [ 11 C]AZ3391 by Schou, M, Pike, A, Jucaite, A, Johnstrom, P, Gonzalez, MC, Hognasbacka, A, Dahl, K, Ghosh, A, Johannes, J, Staniszewska, A, Leo, E, Hamerlik, P, Davies, B, Cosulich, S, Swales, J, Lawrence, R, Squatrito, M, Mueller, N, Sousa, V, Bartek, J, Stragliotto, G, Stenkrona, P, Farde, L, Halldin, C, Cselenyi, Z

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Author Correction: BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity by Rasmussen, Rikke D., Gajjar, Madhavsai K., Tuckova, Lucie, Jensen, Kamilla E., Maya-Mendoza, Apolinar, Holst, Camilla B., Møllgård, Kjeld, Rasmussen, Jane S., Brennum, Jannick, Bartek, Jiri, Syrucek, Martin, Sedlakova, Eva, Andersen, Klaus K., Frederiksen, Marie H., Bartek, Jiri, Hamerlik, Petra

“…This Article contains an error in the spelling of the author Kjeld Møllgård, which is incorrectly given as Kjeld Møllgaard. The error has not been fixed in the…”
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SC-22 GLIOMA STEM CELLS INTERNALIZE BEVACIZUMAB FOUND IN THE PERIVASCULAR NICHE AND TARGET IT FOR RECYCLING OR DEGRADATION by Muller-Greven, G., Carlin, C., Lathia, J., Rich, J., Hamerlik, P., Gladson, C.

“…Antiangiogenic therapy shows great promise for treatment of cancer. Bevacizumab is a humanized mAb that blocks VEGF-A, thereby inhibiting angiogenesis. It has…”
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