Search Results - "Hamelmann Eckard"

Establishment of the intestinal microbiota and its role for atopic dermatitis in early childhood by Penders, John, PhD, Gerhold, Kerstin, MD, PhD, Stobberingh, Ellen E., PhD, Thijs, Carel, MD, PhD, Zimmermann, Kurt, PhD, Lau, Susanne, MD, PhD, Hamelmann, Eckard, MD, PhD

“…Background Perturbations in the intestinal microbiota may disrupt mechanisms involved in the development of immunologic tolerance. The present study aimed to…”
Get full text

Efficacy and Safety of Tiotropium in Children and Adolescents by Hamelmann, Eckard, Szefler, Stanley J.

“…Asthma is one of the most common chronic diseases in children, with a high proportion of patients demonstrating poor control despite the availability of…”
Get full text

A randomised controlled trial of tiotropium in adolescents with severe symptomatic asthma by Hamelmann, Eckard, Bernstein, Jonathan A, Vandewalker, Mark, Moroni-Zentgraf, Petra, Verri, Daniela, Unseld, Anna, Engel, Michael, Boner, Attilio L

“…We present results from the first phase III trial of once-daily tiotropium add-on to inhaled corticosteroids (ICS) plus one or more controller therapies in…”
Get full text

Tiotropium add-on therapy in adolescents with moderate asthma: A 1-year randomized controlled trial by Hamelmann, Eckard, MD, Bateman, Eric D., MD, Vogelberg, Christian, MD, Szefler, Stanley J., MD, Vandewalker, Mark, MD, Moroni-Zentgraf, Petra, MD, Avis, Mandy, PhD, Unseld, Anna, MSc, Engel, Michael, MD, Boner, Attilio L., MD

“…Background Results from phase III clinical trials in adults and phase II clinical trials in children and adolescents demonstrate that tiotropium is an…”
Get full text

Toward clinically applicable biomarkers for asthma: An EAACI position paper by Diamant, Zuzana, Vijverberg, Susanne, Alving, Kjell, Bakirtas, Arzu, Bjermer, Leif, Custovic, Adnan, Dahlen, Sven‐Erik, Gaga, Mina, Gerth van Wijk, Roy, Giacco, Stefano Del, Hamelmann, Eckard, Heaney, Liam G., Heffler, Enrico, Kalayci, Ömer, Kostikas, Konstantinos, Lutter, Rene, Olin, Anna‐Carin, Sergejeva, Svetlana, Simpson, Angela, Sterk, Peter J., Tufvesson, Ellen, Agache, Ioana, Seys, Sven F.

“…Inflammation, structural, and functional abnormalities within the airways are key features of asthma. Although these processes are well documented, their…”
Get full text

Childhood asthma outcomes during the COVID‐19 pandemic: Findings from the PeARL multi‐national cohort by Papadopoulos, Nikolaos G., Mathioudakis, Alexander G., Custovic, Adnan, Deschildre, Antoine, Phipatanakul, Wanda, Wong, Gary, Xepapadaki, Paraskevi, Abou‐Taam, Rola, Agache, Ioana, Castro‐Rodriguez, Jose A., Chen, Zhimin, Cros, Pierrick, Dubus, Jean‐Christophe, El‐Sayed, Zeinab Awad, El‐Owaidy, Rasha, Feleszko, Wojciech, Fierro, Vincenzo, Fiocchi, Alessandro, Garcia‐Marcos, Luis, Goh, Anne, Hossny, Elham M., Huerta Villalobos, Yunuen R., Jartti, Tuomas, Le Roux, Pascal, Levina, Julia, López García, Aida Inés, Ramos, Ángel Mazón, Morais‐Almeida, Mário, Murray, Clare, Nagaraju, Karthik, Nagaraju, Major K., Navarrete Rodriguez, Elsy Maureen, Namazova‐Baranova, Leyla, Nieto Garcia, Antonio, Pozo Beltrán, Cesar Fireth, Ratchataswan, Thanaporn, Rivero Yeverino, Daniela, Rodríguez Zagal, Eréndira, Schweitzer, Cyril E., Tulkki, Marleena, Wasilczuk, Katarzyna, Xu, Dan, Alekseeva, Anna, Almeida, Bethan, Andre, Maud, Arimova, Polina, Blonde, Aurore, Cunningham, Amparito, Da Mota, Sofia, Efendieva, Kamilla, Kalugina, Vera, Kiefer, Sébastien, Klein, Anais, López, Chrystopherson Gengyny Caballero, López, Juan Jesús Ríos, Moratellti, Caroline, Fuentes Pérez, Miguel, Simermann, Meryl, Tapia, José Sergio Papaqui, Tatopoulos, Aurelie, Vishneva, Elena, Volkov, Κonstantin, Bacharier, Leonard, Bonini, Matteo, Craig, Timothy, Diamant, Zuzana, Ducharme, Francine M, Gern, James E., Grigg, Jonathan, Hamelmann, Eckard H, Hedlin, Gunilla, Jartti, Tuomas, Kalayci, Omer, Kaplan, Alan, Konradsen, Jon, Kuna, Piotr, Lau, Susanne, Le Souef, Peter, Lemanske, Robert F, Makela, Mika J, Matricardi, Paolo M, Gómez, René‐Maximiliano, Miligkos, Michael, Pitrez, Paulo MC, Price, David, Pohunek, Petr, Roberts, Graham C, Sheikh, Aziz, Tsiligianni, Ioanna, Turner, Steve, Valiulis, Arunas, Winders, Tonya, Yusuf, Osman M, Zar, Heather

“…Background The interplay between COVID‐19 pandemic and asthma in children is still unclear. We evaluated the impact of COVID‐19 pandemic on childhood asthma…”
Get full text

A phase III randomized controlled trial of tiotropium add-on therapy in children with severe symptomatic asthma by Szefler, Stanley J., MD, Murphy, Kevin, MD, Harper, Thomas, MD, Boner, Attilio, MD, Laki, István, MD, Engel, Michael, MD, El Azzi, Georges, MD, Moroni-Zentgraf, Petra, MD, Finnigan, Helen, MSc, Hamelmann, Eckard, MD

“…Background Studies in adults and adolescents have demonstrated that tiotropium is efficacious as an add-on therapy to inhaled corticosteroids (ICSs) with or…”
Get full text

Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells by Vu Van, Dana, Beier, Katja C., Pietzke, Lea-Jean, Al Baz, Maysun S., Feist, Randi K., Gurka, Stephanie, Hamelmann, Eckard, Kroczek, Richard A., Hutloff, Andreas

“…Autoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close…”
Get full text

Chronic stridor in a toddler after ingestion of a discharged button battery: a case report by Oftring, Zoe S, Mehrtens, Doortje M, Mollin, Julian, Hamelmann, Eckard, Gaus, Sebastian

“…Button battery (BB) ingestions (BBI) are increasingly prevalent in children and constitute a significant, potentially life-threatening health hazard, and thus…”
Get full text

Modified oral food challenge used with sensitization biomarkers provides more real-life clinical thresholds for peanut allergy by Blumchen, Katharina, MD, Beder, Alena, Beschorner, John, MD, Ahrens, Frank, MD, Gruebl, Armin, MD, Hamelmann, Eckard, MD, Hansen, Gesine, MD, Heinzmann, Andrea, MD, Nemat, Katja, MD, Niggemann, Bodo, MD, Wahn, Ulrich, MD, Beyer, Kirsten, MD

“…Background Threshold levels for peanut allergy determined by using oral challenges are important for the food industry with regard to allergen labeling…”
Get full text

A comparison of tiotropium, long-acting β2-agonists and leukotriene receptor antagonists on lung function and exacerbations in paediatric patients with asthma by Vogelberg, Christian, Goldstein, Stanley, Graham, LeRoy, Kaplan, Alan, de la Hoz, Alberto, Hamelmann, Eckard

“…Abstract Diagnosing and treating asthma in paediatric patients remains challenging, with many children and adolescents remaining uncontrolled despite…”
Get full text

Tiotropium add-on therapy is safe and reduces seasonal worsening in paediatric asthma patients by Vogelberg, Christian, Szefler, Stanley J, Vrijlandt, Elianne J L E, Boner, Attilio L, Engel, Michael, El Azzi, Georges, Vulcu, Sebastian Dan, Moroni-Zentgraf, Petra M, Eickmeier, Olaf, Hamelmann, Eckard H

“…There remains an unmet need for effective, well-tolerated therapeutic options in paediatric patients with not fully controlled asthma, for whom safety is of…”
Get full text

A Helminth Immunomodulator Reduces Allergic and Inflammatory Responses by Induction of IL-10-Producing Macrophages by Schnoeller, Corinna, Rausch, Sebastian, Pillai, Smitha, Avagyan, Angela, Wittig, Bianca M, Loddenkemper, Christoph, Hamann, Alf, Hamelmann, Eckard, Lucius, Richard, Hartmann, Susanne

“…The coincidence between infections with parasitic worms and the reduced prevalence of allergic disease in humans and in animal models has prompted the search…”
Get full text

Inflammatory Markers in Induced Sputum of School Children Born Before 32 Completed Weeks of Gestation by Teig, Norbert, MD, Allali, Manel, MD, Rieger, Christian, PhD, Hamelmann, Eckard, PhD

“…Objective To test whether chronic bronchial inflammation may be a contributing risk factor for persistent airflow limitation in children born before 32 weeks…”
Get full text

Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases by Hanusch, Beatrice, Sinningen, Kathrin, Brinkmann, Folke, Dillenhöfer, Stefanie, Frank, Mirjam, Jöckel, Karl-Heinz, Koerner-Rettberg, Cordula, Holtmann, Martin, Legenbauer, Tanja, Langrock, Christian, Reinehr, Thomas, Maasjosthusmann, Patricia, Beckmann, Bibiana, Hamelmann, Eckard, Tsikas, Dimitrios, Lücke, Thomas

“…L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent…”
Get full text

Ingestion of several rubber gloves: A case report on Pica syndrome by Winterland, Sarah, Schmidt, Jeremy, Nordhoff, Dennis, Barthlen, Winfried, Hamelmann, Eckard, Gaus, Sebastian

“…Key Clinical Message After ingestion rubber gloves harden and can produce dangerous complications. Therefore the choice of treatment is of utmost importance…”
Get full text

Comparing LAMA with LABA and LTRA as add-on therapies in primary care asthma management by Kaplan, Alan, FitzGerald, J. Mark, Buhl, Roland, Vogelberg, Christian, Hamelmann, Eckard

“…The Global Initiative for Asthma recommends a stepwise approach to adjust asthma treatment to the needs of individual patients; inhaled corticosteroids (ICS)…”
Get full text

EUFOREUM Berlin 2023: Optimizing care for type 2 inflammatory diseases from clinic to AI: A pediatric focus by Conti, Diego M., Vibeke, Backer, Kirsten, Beyer, Leif, Bjermer, Adam, Chaker, Stephanie, Dramburg, Mina, Gaga, Monika, Gappa, Philippe, Gevaert, Eckard, Hamelmann, Hellings, Peter W., Milos, Jesenak, Kopp, Matthias V., Marcus, Maurer, Marcia, Podesta, Dermot, Ryan, Scadding, Glenis K., Eike, Wüstenberg, Ulrich, Wahn, Susanne, Lau

“…The European Forum for Research and Education in Allergy and Airways diseases (EUFOREA) organized its bi‐annual forum EUFOREUM in Berlin in November 2023. The…”
Get full text

Diversities of allergic pathologies and their modifiers: Report from the second DGAKI-JSA meeting by Asano, Koichiro, Tamari, Mayumi, Zuberbier, Torsten, Yasudo, Hiroki, Morita, Hideaki, Fujieda, Shigeharu, Nakamura, Yuumi, Traidl, Stephan, Hamelmann, Eckard, Raap, Ulrike, Babina, Magda, Nagase, Hiroyuki, Okano, Mitsuhiro, Katoh, Norito, Ebisawa, Motohiro, Renz, Harald, Izuhara, Kenji, Worm, Margitta

“…In October 2021, researchers from the German Society of Allergy and Clinical Immunology (DGAKI) and from the Japanese Society of Allergology (JSA) focused…”
Get full text

Early identification of atopy in the prediction of persistent asthma in children by Sly, Peter D, Prof, Boner, Attilio L, Prof, Björksten, Bengt, Prof, Bush, Andy, Prof, Custovic, Adnan, Prof, Eigenmann, Philippe A, Prof, Gern, James E, Prof, Gerritsen, Jorrit, Prof, Hamelmann, Eckard, Prof, Helms, Peter J, Prof, Lemanske, Robert F, Prof, Martinez, Fernando, Prof, Pedersen, Soren, Prof, Renz, Harald, Prof, Sampson, Hugh, Prof, von Mutius, Erika, Prof, Wahn, Ulrich, Prof, Holt, Patrick G, Prof

“…Summary The long-term solution to the asthma epidemic is thought to be prevention, and not treatment of established disease. Atopic asthma arises from…”
Get full text