Search Results - "Hamelin, David"

Conformational sampling of membranes by Akt controls its activation and inactivation by Lučić, Iva, Rathinaswamy, Manoj K., Truebestein, Linda, Hamelin, David J., Burke, John E., Leonard, Thomas A.

“…The protein kinase Akt controls myriad signaling processes in cells, ranging from growth and proliferation to differentiation and metabolism. Akt is activated…”
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Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 by Jenkins, Meredith L., Margaria, Jean Piero, Stariha, Jordan T. B., Hoffmann, Reece M., McPhail, Jacob A., Hamelin, David J., Boulanger, Martin J., Hirsch, Emilio, Burke, John E.

“…The GTPase Rab11 plays key roles in receptor recycling, oogenesis, autophagosome formation, and ciliogenesis. However, investigating Rab11 regulation has been…”
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Probing the Architecture, Dynamics, and Inhibition of the PI4KIIIα/TTC7/FAM126 Complex by Dornan, Gillian L., Dalwadi, Udit, Hamelin, David J., Hoffmann, Reece M., Yip, Calvin K., Burke, John E.

“…Phosphatidylinositol 4-kinase IIIα (PI4KIIIα) is the lipid kinase primarily responsible for generating the lipid phosphatidylinositol 4-phosphate (PI4P) at the…”
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MhcVizPipe: A Quality Control Software for Rapid Assessment of Small- to Large-Scale Immunopeptidome Datasets by Kovalchik, Kevin A., Ma, Qing, Wessling, Laura, Saab, Frederic, Duquette, Jérôme D., Kubiniok, Peter, Hamelin, David J., Faridi, Pouya, Li, Chen, Purcell, Anthony W., Jang, Anne, Paramithiotis, Eustache, Tognetti, Marco, Reiter, Lukas, Bruderer, Roland, Lanoix, Joël, Bonneil, Éric, Courcelles, Mathieu, Thibault, Pierre, Caron, Etienne, Sirois, Isabelle

“…MS-based immunopeptidomics is maturing into an automatized and high-throughput technology, producing small- to large-scale datasets of clinically relevant…”
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The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme by Shanbhogue, Prajna, Hoffmann, Reece M., Airola, Michael V., Maini, Rohan, Hamelin, David J., Garcia-Diaz, Miguel, Burke, John E., Hannun, Yusuf A.

“…Neutral sphingomyelinase 2 (nSMase2) produces the bioactive lipid ceramide and has important roles in neurodegeneration, cancer, and exosome formation…”
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Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from Toxoplasma gondii by Powell, Cameron J., Ramaswamy, Raghavendran, Kelsen, Anne, Hamelin, David J., Warshaw, David M., Bosch, Jürgen, Burke, John E., Ward, Gary E., Boulanger, Martin J.

“…Parasites of the phylum Apicomplexa are responsible for significant morbidity and mortality on a global scale. Central to the virulence of these pathogens are…”
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The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA-supertype-dependent manner by Hamelin, David J, Fournelle, Dominique, Grenier, Jean-Christophe, Schockaert, Jana, Kovalchik, Kevin A, Kubiniok, Peter, Mostefai, Fatima, Duquette, Jérôme D, Saab, Frederic, Sirois, Isabelle, Smith, Martin A, Pattijn, Sofie, Soudeyns, Hugo, Decaluwe, Hélène, Hussin, Julie, Caron, Etienne

“…The rapid, global dispersion of SARS-CoV-2 has led to the emergence of a diverse range of variants. Here, we describe how the mutational landscape of…”
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La difficile acquisition de la « science de son malheur by Hamelin, David

“…La construction et le développement du syndicalisme français à la Belle Époque s’accompagnent de l’exigence partagée de construire des savoirs militants. Ils…”
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Understanding the constitutive presentation of MHC class I immunopeptidomes in primary tissues by Kubiniok, Peter, Marcu, Ana, Bichmann, Leon, Kuchenbecker, Leon, Schuster, Heiko, Hamelin, David J., Duquette, Jérôme D., Kovalchik, Kevin A., Wessling, Laura, Kohlbacher, Oliver, Rammensee, Hans-Georg, Neidert, Marian C., Sirois, Isabelle, Caron, Etienne

“…Understanding the molecular principles that govern the composition of the MHC-I immunopeptidome across different primary tissues is fundamentally important to…”
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RHybridFinder: An R package to process immunopeptidomic data for putative hybrid peptide discovery by Saab, Frederic, Hamelin, David J., Ma, Qing, Kovalchik, Kevin A., Sirois, Isabelle, Faridi, Pouya, Li, Chen, Purcell, Anthony W., Kubiniok, Peter, Caron, Etienne

“…Identification of proteasomal spliced peptides (PSPs) by mass spectrometry (MS) is not possible with traditional search engines. Here, we provide a protocol…”
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A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion by Heitz, Samantha D., Hamelin, David J., Hoffmann, Reece M., Greenberg, Nili, Salloum, Gilbert, Erami, Zahra, Khalil, Bassem D., Shymanets, Aliaksei, Steidle, Elizabeth A., Gong, Grace Q., Nürnberg, Bernd, Burke, John E., Flanagan, Jack U., Bresnick, Anne R., Backer, Jonathan M.

“…Phosphoinositide 3-kinase β (PI3Kβ) is regulated by receptor tyrosine kinases (RTKs), G protein–coupled receptors (GPCRs), and small GTPases such as Rac1 and…”
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Population Genomics Approaches for Genetic Characterization of SARS-CoV-2 Lineages by Mostefai, Fatima, Gamache, Isabel, N'Guessan, Arnaud, Pelletier, Justin, Huang, Jessie, Murall, Carmen Lia, Pesaranghader, Ahmad, Gaonac'h-Lovejoy, Vanda, Hamelin, David J, Poujol, Raphaël, Grenier, Jean-Christophe, Smith, Martin, Caron, Etienne, Craig, Morgan, Wolf, Guy, Krishnaswamy, Smita, Shapiro, B Jesse, Hussin, Julie G

“…The genome of the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), the pathogen that causes coronavirus disease 2019 (COVID-19), has been…”
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Quand les syndicats se saisissent de l’image by Béroud, Sophie, Hamelin, David

“…Tout au long de son histoire, ancienne ou récente, le syndicalisme, qu’il soit salarié, agricole, étudiant ou patronal, catégoriel ou interprofessionnel, local…”
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Rendre accessibles et valoriser les archives visuelles du syndicalisme by Baumard, Raphaël, Hamelin, David

“…Vous est-il possible de revenir sur ce que sont les Archives nationales du monde du travail ? Les Archives nationales du monde du travail ont ouvert au public…”
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Introduction : Les migrations internationales au prisme du travail by Hamelin, David

“…L’immigration dans toute sa complexité est un sujet que l’actualité appréhende de la plus mauvaise des façons. Médias et organisations politiques surtout, que…”
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La fabrique européenne de la race (17e-20e siècles) : Introduction by Hamelin, David, Jahan, Sébastien

“…Dans un article de la revue Mouvements paru en 2007, le philosophe Étienne Balibar évoquait le « retour de la race », un retour qui s’opère non pas de manière…”
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Pour une histoire du travail by Hamelin, David

“…L’Association française pour l’histoire des mondes du travail (AFHMT) a été constituée le 15 juin 2013. Cette nouvelle structure, initiée par Nicolas Hatzfeld,…”
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Introduction : Ce que l’engagement fait aux savoirs, ce que les savoirs font à l’engagement by Hamelin, David, Lamy, Jérôme, Willemez, Laurent

“…Les articulations entre les formes d’engagement politique et l’accumulation d’un certain nombre de connaissances opérationnelles pour la lutte font aujourd’hui…”
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Les enjeux d’une meilleure articulation entre immigration, travail, histoire et mémoire by Ouaddane, Mohammed, Hamelin, David

“…Depuis une trentaine d’années, une foule d’initiatives et de mobilisations participent à l’émergence d’une mémoire de l’immigration. La question du travail,…”
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Aux sources de l’histoire syndicale française, retour sur les Bourses du travail by Hamelin, David

“…Toute recherche portant sur les Bourses du travail se trouve très rapidement confrontée à une situation pour le moins déstabilisante pour l’historien. Bien que…”
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