Search Results - "Hamed, Kamal A"

Safety and pharmacokinetics of SPR206 in subjects with varying degrees of renal impairment by Bruss, Jon B, Bader, Justin, Hamed, Kamal A

“…SPR206 is a novel polymyxin derivative with potent activity against susceptible and multidrug-resistant strains of , , , , and species. SPR206 is eliminated…”
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Efficacy of SPR720 in murine models of non-tuberculous mycobacterial pulmonary infection by Cotroneo, Nicole, Stokes, Suzanne S, Pucci, Michael J, Rubio, Aileen, Hamed, Kamal A, Critchley, Ian A

“…Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is increasing worldwide, with Mycobacterium avium complex (MAC) and Mycobacterium abscessus as the…”
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Ceftobiprole Compared With Vancomycin Plus Aztreonam in the Treatment of Acute Bacterial Skin and Skin Structure Infections: Results of a Phase 3, Randomized, Double-blind Trial (TARGET) by Overcash, J Scott, Kim, Charles, Keech, Richard, Gumenchuk, Illia, Ninov, Borislav, Gonzalez-Rojas, Yaneicy, Waters, Michael, Simeonov, Simeon, Engelhardt, Marc, Saulay, Mikael, Ionescu, Daniel, Smart, Jennifer I, Jones, Mark E, Hamed, Kamal A

“…The development of novel broad-spectrum antibiotics, with efficacy against both gram-positive and gram-negative bacteria, has the potential to enhance…”
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A Phase 3, Randomized, Investigator-blinded Trial Comparing Ceftobiprole With a Standard-of-care Cephalosporin, With or Without Vancomycin, for the Treatment of Pneumonia in Pediatric Patients by Bosheva, Miroslava, Gujabidze, Rusudan, Károly, Éva, Nemeth, Agnes, Saulay, Mikael, Smart, Jennifer I., Hamed, Kamal A.

“…The advanced-generation, broad-spectrum, intravenous (IV) cephalosporin, ceftobiprole, is an effective and well-tolerated treatment for adults with…”
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Impact of antibiotic pharmacokinetics in urine on recurrent bacteriuria following treatment of complicated urinary tract infections by Melnick, David, Talley, Angela K., Gupta, Vipul K., Critchley, Ian A., Eckburg, Paul B., Hamed, Kamal A., Bhatt, Nivedita, Moore, Gary, Austin, Daren, Rubino, Christopher M., Bhavnani, Sujata M., Ambrose, Paul G.

“…ABSTRACT The clinical relevance of bacteriuria following antibiotic treatment of complicated urinary tract infections in clinical trials remains controversial…”
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Ceftobiprole Activity against Bacteria from Skin and Skin Structure Infections in the United States from 2016 through 2018 by Flamm, Robert K, Duncan, Leonard R, Hamed, Kamal A, Smart, Jennifer I, Mendes, Rodrigo E, Pfaller, Michael A

“…Ceftobiprole medocaril is an advanced-generation cephalosporin prodrug that has qualified infectious disease product status granted by the US FDA and is…”
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Ceftobiprole Activity against Gram-Positive and -Negative Pathogens Collected from the United States in 2006 and 2016 by Pfaller, Michael A, Flamm, Robert K, Mendes, Rodrigo E, Streit, Jennifer M, Smart, Jennifer I, Hamed, Kamal A, Duncan, Leonard R, Sader, Helio S

“…Ceftobiprole is an advanced cephalosporin with potent activity against Gram-positive and Gram-negative bacteria that has been approved in many European and…”
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Ceftobiprole activity against Gram-positive and Gram-negative pathogens causing bone and joint infections in the United States from 2016 to 2020 by Duncan, Leonard R., Hamed, Kamal A., Smart, Jennifer I., Pfaller, Michael A., Flamm, Robert K., Mendes, Rodrigo E.

“…Bone and joint infections (BJIs) present significant treatment challenges. Ceftobiprole, a broad-spectrum cephalosporin with activity against…”
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Ceftobiprole activity when tested against contemporary bacteria causing bloodstream infections in the United States (2016–2017) by Pfaller, Michael A., Flamm, Robert K., Duncan, Leonard R., Shortridge, Dee, Smart, Jennifer I., Hamed, Kamal A., Mendes, Rodrigo E., Sader, Helio S.

“…Ceftobiprole medocaril, the prodrug of ceftobiprole, is an advanced-generation cephalosporin that is approved in many European and non-European countries for…”
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Evaluation of Factors Predictive of Efficacy Among Patients With Complicated Urinary Tract Infection and/or Acute Pyelonephritis by Bhavnani, Sujata M, Hammel, Jeffrey P, Rubino, Christopher M, Talley, Angela K, Eckburg, Paul B, Liolios, Kathryn, Gupta, Vipul K, Ambrose, Paul G, Hamed, Kamal A, Melnick, David A

“…Abstract Background Antibiotic treatment for complicated urinary tract infections (cUTI)/acute pyelonephritis (AP) is often followed by recurrent bacteriuria…”
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Successful Treatment of Primary Actinomyces viscosus Endocarditis with Third-Generation Cephalosporins by Hamed, Kamal A.

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Randomized, Investigator-Blinded, Multicenter, Comparative Study of Gatifloxacin Versus Amoxicillin/Clavulanate in Recurrent Otitis Media and Acute Otitis Media Treatment Failure in Children by Sher, Lawrence, Arguedas, Adriano, Husseman, Michael, Pichichero, Michael, Hamed, Kamal A, Biswas, Debjit, Pierce, Phillip, Echols, Roger

“…BACKGROUND:Recurrent otitis media and acute otitis media treatment failure are commonly encountered in the pediatric population. OBJECTIVE:To compare the…”
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Randomized, Investigator-Blinded, Multicenter Study of Gatifloxacin Versus Amoxicillin/Clavulanate Treatment of Recurrent and Nonresponsive Otitis Media in Children by Sáez-Llorens, Xavier, Rodriguez, Adib, Arguedas, Adriano, Hamed, Kamal A, Yang, Joanna, Pierce, Phillip, Echols, Roger

“…BACKGROUND:Decreased susceptibility of pathogens to currently used agents for recurrent otitis media has provided the impetus for identifying new antimicrobial…”
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Comparison of once-daily extended-release ciprofloxacin and conventional twice-daily ciprofloxacin for the treatment of uncomplicated urinary tract infection in women by Henry, Dan C., Bettis, Robert B., Riffer, Ernie, Haverstock, Daniel C., Kowalsky, Steven F., Manning, Kathryn, Hamed, Kamal A., Church, Deborah A.

“…Background: Trimethoprim/sulfamethoxazole (TMP/SMX) is currently the first choice for empiric therapy of acute uncomplicated urinary tract infection (UTI) in…”
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Bacteriologic and clinical efficacy of oral gatifloxacin for the treatment of recurrent/nonresponsive acute otitis media: an open label, noncomparative, double tympanocentesis study by LEIBOVITZ, EUGENE, PIGLANSKY, LOLITA, RAIZ, SIMON, GREENBERG, DAVID, HAMED, KAMAL A, LEDEINE, JEAN-MARIE, PRESS, JOSEPH, LEIBERMAN, ALBERTO, ECHOLS, ROGER M, PIERCE, PHILLIP F, JACOBS, MICHAEL R, DAGAN, RON

“…BACKGROUND.Gatifloxacin is an 8-methoxyfluoroquinolone with good activity against respiratory pathogens. OBJECTIVES.To document the bacteriologic and clinical…”
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A Phase 3, Randomized, Investigator-blinded Trial Comparing Ceftobiprole With a Standard-of-care Cephalosporin, With or Without Vancomycin, for the Treatment of Pneumonia in Pediatric Patients by Bosheva, Miroslava, Gujabidze, Rusudan, Károly, Éva, Nemeth, Agnes, Saulay, Mikael, Smart, Jennifer I., Hamed, Kamal A.

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The diagnostic and prognostic performance of transforming growth factor-B and survivin as non-invasive biomarkers for hepatitis C related hepatocellular carcinoma: a longitudinal study by Kamal, S, Fathi Soliman Mohamed, A, Halim Moustafa, A, Hamed Kamal, A, AbdelHakam, S, Ghoraba, D A

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Kaposi's sarcoma of the breast by Hamed, K A, Muller, K E, Nawab, R A

“…Kaposi's sarcoma of the breast is extremely rare. We report a case of a patient with AIDS presenting with Kaposi's sarcoma localized to the breast and review…”
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Haemophilus parainfluenzae Endocarditis: Application of a Molecular Approach for Identification of Pathogenic Bacterial Species by Hamed, Kamal A., Dormitzer, Philip R., Su, Catherine K., Relman, David A.

“…Haemophilus parainfluenzae is both a human oropharyngeal commensal bacterium and a cause of serious invasive disease. The fastidious growth characteristics of…”
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Pulmonary mucormycosis presenting as an endobronchial lesion by Husari, A W, Jensen, W A, Kirsch, C M, Campagna, A C, Kagawa, F T, Hamed, K A, Azzi, R L, Stevens, D A

“…A 56-year-old diabetic man presented with left upper lobe collapse and postobstructive pneumonitis. Fiberoptic bronchoscopy revealed an endobronchial mass…”
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