Search Results - "Hamdulay, S"

Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State by ZAKKAR, Mustafa, VAN DER HEIDEN, Kim, HASKARD, Dorian O, MASON, Justin C, EVANS, Paul C, LUONG, Le Anh, CHAUDHURY, Hera, CUHLMANN, Simon, HAMDULAY, Shahir S, KRAMS, Rob, EDIRISINGHE, Indika, RAHMAN, Irfan, CARLSEN, Harald

“…Proinflammatory mediators influence atherosclerosis by inducing adhesion molecules (eg, VCAM-1) on endothelial cells (ECs) via signaling intermediaries…”
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Is it lupus? TAMA: an important multi-system autoimmune disease entity physicians need to consider by Mouyis, M, Dollman, G, Penn, H, John, L, Hamdulay, S

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Induction of the Cytoprotective Enzyme Heme Oxygenase-1 by Statins Is Enhanced in Vascular Endothelium Exposed to Laminar Shear Stress and Impaired by Disturbed Flow by Ali, Faisal, Zakkar, Mustafa, Karu, Kersti, Lidington, Elaine A., Hamdulay, Shahir S., Boyle, Joseph J., Zloh, Mire, Bauer, Andrea, Haskard, Dorian O., Evans, Paul C., Mason, Justin C.

“…In addition to cholesterol-lowering properties, statins exhibit lipid-independent immunomodulatory, anti-inflammatory actions. However, high concentrations are…”
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IgG4-related disease in a multi-ethnic community: clinical characteristics and association with malignancy by Poo, S X, Tham, C S W, Smith, C, Lee, J, Cairns, T, Galliford, J, Hamdulay, S, Jacyna, M, Levy, J B, McAdoo, S P, Roufosse, C, Wernig, F, Mason, J C, Pusey, C D, Tam, F W K, Tomlinson, J A P

“…Abstract Background Immunoglobulin-G4-related disease (IgG4-RD) is a recently recognized fibro-inflammatory condition that can affect multiple organs. Despite…”
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Serial analysis of clinical and imaging indices reveals prolonged efficacy of TNF-α and IL-6 receptor targeted therapies in refractory Takayasu arteritis by Youngstein, Taryn, Peters, James E, Hamdulay, Shahir S, Mewar, Devesh, Price-Forbes, Alec, Lloyd, Mark, Jeffery, Rachel, Kinderlerer, Anne R, Mason, Justin C

“…We analysed a large cohort of patients with Takayasu arteritis, seeking robust clinical evidence for prolonged responses to tumour necrosis factor-α (TNF-α)…”
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Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin by Kinderlerer, Anne R., Pombo Gregoire, Isabel, Hamdulay, Shahir S., Ali, Faisal, Steinberg, Rivka, Silva, Gabriela, Ali, Nadira, Wang, Bufei, Haskard, Dorian O., Soares, Miguel P., Mason, Justin C.

“…Catabolism of free heme by heme oxygenase-1 (HO-1) generates carbon monoxide, biliverdin, and free iron (Fe). These end-products are responsible for much of…”
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Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium by Hamdulay, Shahir S., Wang, Bufei, Birdsey, Graeme M., Ali, Faisal, Dumont, Odile, Evans, Paul C., Haskard, Dorian O., Wheeler-Jones, Caroline P., Mason, Justin C.

“…Although nonsteroidal anti-inflammatory drugs (NSAIDs) provide important control of pain and inflammation, they have been overshadowed by concerns regarding…”
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Wireless capsule endoscopy in the investigation of intestinal Behçet's syndrome by Hamdulay, S. S., Cheent, K., Ghosh, C., Stocks, J., Ghosh, S., Haskard, D. O.

“…Objective. Intestinal Behçet's Syndrome (BS) is a difficult diagnosis to establish. We describe the use of wireless capsule endoscopy (WCE) in the…”
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When is arthritis reactive? by Hamdulay, S S, Glynne, S J, Keat, A

“…Reactive arthritis is an important cause of lower limb oligoarthritis, mainly in young adults. It is one of the spondyloarthropathy family; it is…”
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Statin‐mediated cytoprotection of human vascular endothelial cells: a role for Kruppel‐like factor 2‐dependent induction of heme oxygenase‐1 by ALI, F., HAMDULAY, S. S., KINDERLERER, A. R., BOYLE, J. J., LIDINGTON, E. A., YAMAGUCHI, T., SOARES, M. P., HASKARD, D. O., RANDI, A. M., MASON, J. C.

“…Background: Heme oxygenase‐1 (HO‐1), by exerting anti‐inflammatory, antiproliferative, antiapoptotic and antioxidant effects in the vasculature, protects…”
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A sleepless young man with red eyes and slurred speech? by Tsui, A., Issacs, A., Cohen, D.L., Hamdulay, S.S.

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Disease-modifying anti-rheumatic drugs: do they reduce cardiac complications of RA? by Hamdulay, Shahir S, Mason, Justin C

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Protein kinase Cε activity induces anti-inflammatory and anti-apoptotic genes via an ERK1/2- and NF-κB-dependent pathway to enhance vascular protection by Dumont, Odile, Mylroie, Hayley, Bauer, Andrea, Calay, Damien, Sperone, Andrea, Thornton, Clare, Hamdulay, Shahir S, Ali, Nadira, Boyle, Joseph J, Choo, Joan R, Samarel, Allen M, Haskard, Dorian O, Randi, Anna M, Evans, Paul C, Mason, Justin C

“…Vascular endothelial injury predisposes to endothelial dysfunction and atherogenesis. We have investigated the hypothesis that PKCε (protein kinase Cε) is an…”
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PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis by Mylroie, Hayley, Dumont, Odile, Bauer, Andrea, Thornton, Clare C, Mackey, John, Calay, Damien, Hamdulay, Shahir S, Choo, Joan R, Boyle, Joseph J, Samarel, Allen M, Randi, Anna M, Evans, Paul C, Mason, Justin C

“…Vascular injury leading to endothelial dysfunction is a characteristic feature of chronic renal disease, diabetes mellitus, and systemic inflammatory…”
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Glucose-insulin and potassium infusions in septic shock by Hamdulay, Shahir S, Al-Khafaji, Ali, Montgomery, Hugh

“…Glucose-insulin and potassium (GIK) infusions are beneficial in treating ischemic myocardial depression. Myocardial depression is also an important feature in…”
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Calciuria, oxaluria and phosphaturia after ingestion of glucose, xylitol and sorbitol in two population groups with different stone-risk profiles by Rodgers, A, Bungane, N, Allie-Hamdulay, S, Lewandowski, S, Webber, D

“…The effects of glucose, sorbitol and xylitol ingestion on calciuria, oxaluria and phosphaturia in healthy black and white males on a standardized diet were…”
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A case of eosinophilic enteritis and rheumatoid arthritis by Ng, W. F., Cohen, P., Hepburn, A., Hamdulay, S., Carpani, M., Mason, J. C.

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A typist with neck pain by Hamdulay, S. S., Miah, N. K., Watts, C. D., Steuer, A.

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Raised Intracranial Pressure (Pseudotumour Cerebri) Associated With Severe Acute Respiratory Syndrome Coronavirus 2 by Balendra, Rubika, North, Matthew, Kumar, Guru, Qutab, Saad, Raouf, Hamid Aminy, Delamont, Shane S., Chong, M. S., Hamdulay, Shahir S., Rahman, Mushtaqur, Robertson, Fergus J., Hoskote, Chandrashekar, Bremner, Fion D., Farmer, Simon F., Watkins, Laurence, Zandi, Michael S., Manji, Hadi, Trip, S. Anand, Paterson, Ross W., Swayne, Orlando B. C.

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PPARδ and PGC1α act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress by Ali, Faisal, Ali, Nadira S., Bauer, Andrea, Boyle, Joseph J., Hamdulay, Shahir S., Haskard, Dorian O., Randi, Anna M., Mason, Justin C.

“…Aims Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily of ligand-activated transcriptional regulators. PPARδ…”
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