Search Results - "Hamdouchi, C."

The nature of electron transfer from metal surfaces to the carbon-halogen bond by Walborsky, H. M, Hamdouchi, C

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Surface nature of Grignard reagent formation. Chiral 1-methylspiro[2.5]octylmagnesium bromide by Hamdouchi, C, Topolski, M, Goedken, V, Walborsky, H. M

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Mechanism of organocalcium reagent formation by Walborsky, H. M, Hamdouchi, C

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Attempts to trap radicals formed in solution by a magnesium surface by Walborsky, H. M., Topolski, M., Hamdouchi, C., Pankowski, J.

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2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imidazo[1,2-a]pyridines as a Novel Class of Inhibitors of Human Rhinovirus:  Stereospecific Synthesis and Antiviral Activity by Hamdouchi, Chafiq, de Blas, Jesús, del Prado, Mirian, Gruber, Joseph, Heinz, Beverly A, Vance, Lori

“…A series of 2-amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imidazo[1,2-a]pyridines 1a − i, structurally related to Enviroxime and its…”
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Structure-based design of a new class of highly selective aminoimidazo[1,2- a]pyridine-based inhibitors of cyclin dependent kinases by Hamdouchi, Chafiq, Zhong, Boyu, Mendoza, Jose, Collins, Elizabeth, Jaramillo, Carlos, De Diego, Jose Eugenio, Robertson, Daniel, Spencer, Charles D., Anderson, Bryan D., Watkins, Scott A., Zhang, Faming, Brooks, Harold B.

“…Structure-based design approach was successfully used to design and discover new structural class of imidazopyridine as highly specific cyclin dependent kinase…”
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Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond by Ciccocioppo, Roberto, Gehlert, Donald R, Ryabinin, Andrey, Kaur, Simranjit, Cippitelli, Andrea, Thorsell, Annika, Lê, Anh D, Hipskind, Philip A, Hamdouchi, Chafiq, Lu, Jianliang, Hembre, Erik J, Cramer, Jeffrey, Song, Min, McKinzie, David, Morin, Michelle, Economidou, Daina, Stopponi, Serena, Cannella, Nazzareno, Braconi, Simone, Kallupi, Marsida, de Guglielmo, Giordano, Massi, Maurizio, George, David T, Gilman, Jody, Hersh, Jacqueline, Tauscher, Johannes T, Hunt, Stephen P, Hommer, Daniel, Heilig, Markus

“…Abstract This article summarizes the proceedings of a symposium held at the conference on “Alcoholism and Stress: A Framework for Future Treatment Strategies”…”
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Imidazo[1,2-b]pyridazines, Novel Nucleus with Potent and Broad Spectrum Activity against Human Picornaviruses:  Design, Synthesis, and Biological Evaluation by Hamdouchi, Chafiq, Sanchez-Martinez, Concha, Gruber, Joseph, del Prado, Miriam, Lopez, Javier, Rubio, Almudena, Heinz, Beverly A

“…A novel structural class of picornavirus inhibitors comprising an imidazo[1,2-b]pyridazine nucleus was discovered. 2-Aminoimidazo[1,2-b]pyridazines (6d,…”
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Novel route to the synthesis of 4-quinolyl isothiocyanates by Zhong, Boyu, Al-Awar, Rima S., Shih, Chuan, Grimes, John H., Vieth, Michal, Hamdouchi, Chafiq

“…4-Quinolyl isothiocyanates were synthesized in a regiospecific fashion from the corresponding 4-chloroquinolines and silver thiocyanate in refluxing toluene…”
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A new approach to the synthesis of 2-aminoimidazo[1,2- a]pyridine derivatives through microwave-assisted N-alkylation of 2-halopyridines by Vega, Juan A., Vaquero, Juan J., Alvarez-Builla, Julio, Ezquerra, Jesús, Hamdouchi, Chafiq

“…A microwave (focused waves) assisted N-alkylation of 2-halopyridines provides a convenient entry to 2-amino-imidazo[1,2- a]pyridine derivatives after reaction…”
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Aminoimidazo[1,2- a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation by Jaramillo, Carlos, de Diego, J. Eugenio, Hamdouchi, Chafiq, Collins, Elizabeth, Keyser, Heather, Sánchez-Martı́nez, Concha, del Prado, Miriam, Norman, Bryan, Brooks, Harold B., Watkins, Scott A., Spencer, Charles D., Dempsey, Jack Alan, Anderson, Bryan D., Campbell, Robert M., Leggett, Tellie, Patel, Bharvin, Schultz, Richard M., Espinosa, Juan, Vieth, Michal, Zhang, Faming, Timm, David E.

“…Synthesis of 2-aminoimidazo[1,2- a]pyridines 1 and their evaluation as CDK2 inhibitors is described. We have identified a novel structural class of protein…”
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P 4.1. MTIP: a novel brain penetrant, orally available corticotropin-releasing hormone receptor 1 (CRH-R1) antagonist for treatment of alcoholism by Gehlert, DR, Cippitelli, A, Thorsell, A, Le, AD, Hipskind, P A, Hamdouchi, C, Lu, J, Hembre, E J, Cramer, J, Song, M, McKinzie, D, Morin, M, Ciccocioppo, R, Heilig, M

“…We describe a novel CRH-R1 antagonist with advantageous properties for clinical development, and its in vivo activity in preclinical alcoholism models…”
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The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines by Hamdouchi, Chafiq, Keyser, Heather, Collins, Elizabeth, Jaramillo, Carlos, De Diego, Jose Eugenio, Spencer, Charles D, Dempsey, Jack Alan, Anderson, Bryan D, Leggett, Tillie, Stamm, Nancy B, Schultz, Richard M, Watkins, Scott A, Cocke, Kim, Lemke, Stephanie, Burke, Teresa F, Beckmann, Richard P, Dixon, Jeffrey T, Gurganus, Thomas M, Rankl, Nancy B, Houck, Keith A, Zhang, Faming, Vieth, Michal, Espinosa, Juan, Timm, David E, Campbell, Robert M, Patel, Bharvin K R, Brooks, Harold B

“…The protein kinase family represents an enormous opportunity for drug development. However, the current limitation in structural diversity of kinase inhibitors…”
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On the reaction of chiral sulfinimines with sulfur ylides: a novel route to the asymmetric aziridination by García Ruano, JoséL, Fernández, Inmaculada, Hamdouchi, Chafiq

“…The reaction of optically pure N-sulfinyl phenylimine with dimethyloxosulfonium methylide ( A) and dimethylsulfonium methylide ( B) yields a mixture of…”
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A novel application of the Ullmann coupling reaction for the alkylsulfenylation of 2-amino-imidazo[1,2- a]pyridine by Hamdouchi, Chafiq, de Blas, Jesús, Ezquerra, Jesús

“…The Ullmann coupling reaction between the 2-trifluoroacetamido-3-iodo-6-benzoylimidazo[1,2- a]pyridine and dialkyldisulfides (Me, iPr) mediated by copper…”
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Regioselective synthesis of 3,6-disubstituted-2-aminoimidazo[1,2- a]pyridines by Jaramillo, Carlos, Carretero, Juan Carlos, de Diego, J.Eugenio, del Prado, Miriam, Hamdouchi, Chafiq, Roldán, José Luis, Sánchez-Martı́nez, Concha

“…A convenient synthesis of 3,6-disubstituted-2-aminoimidazo[1,2- a]pyridines 3 is described. A halogen–metal exchange study on building block 1 showed that use…”
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A novel approach to the regioselective acylation of spirocyclic C-glucoside of papulacandins by Hamdouchi, Chafiq, Jaramillo, Carlos, Lopez-Prados, Javier, Rubio, Almudena

“…A novel approach to the regioselective acylation of spirocyclic C-glucoside of papulacandins is reported. Conditions were found to effect regioselective…”
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Short synthesis and anti-rhinoviral activity of imidazo[1,2- a]pyridines: The effect of acyl groups at 3-position by Hamdouchi, Chafiq, Ezquerra, Jesús, Vega, Juan A, Vaquero, Juan J, Alvarez-Builla, Julio, Heinz, Beverly A

“…Various 2-amino-3-acyl-6-[( E)-1-phenyl-2- N-methylcarbamoylvinyl]-imidazo[1,2- a]pyridines, structurally related to Enviroxime were prepared to determine the…”
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New approach to the stereoselective synthesis of the [4.5] spiroketal moiety of papulacandins by Canetero, Juan C., de Diego, J.Eugenio, Hamdouchi, Chafiq

“…An efficient approach for the stereoselective construction of the spiroketal moiety of papulacandins, based on the condensation of the protected derivative of…”
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A new stereocontrolled entry into the anthracyclinone families. Part 1: Synthesis of bicyclic precursors of 4-demethoxy-7-deoxy-derivatives by Garcı́a Ruano, José L., Garcı́a Paredes, Cristina, Hamdouchi, Chafiq

“…A new and versatile strategy to obtain enantiomerically pure bicyclic precursors of compounds belonging to different anthracyclinone families is reported…”
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