Validity of magnetic resonance image and HLA-B27 in early detection of sacroiliitis in Egyptian spondyloarthropathic patients
Objective The aim of this study was to compare the validity of MRI in the early detection of sacroiliitis with laboratory findings of human leukocyte antigen-B27 (HLA-B27), conventional radiography, and clinical assessment. Participants and methods Sixty patients with spondyloarthropathy (group II)...
Saved in:
| Published in: | Egyptian Rheumatology and Rehabilitation Vol. 42; no. 3; pp. 137 - 144 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Cairo, Egypt
The Egyptian Society for Rheumatology and Rehabilitation
01-07-2015
Springer Berlin Heidelberg Springer Nature B.V SpringerOpen |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Objective
The aim of this study was to compare the validity of MRI in the early detection of sacroiliitis
with laboratory findings of human leukocyte antigen-B27 (HLA-B27), conventional radiography,
and clinical assessment.
Participants and methods
Sixty patients with spondyloarthropathy (group II) with duration of illness less than 2 years
and 20 healthy controls (group I) were included in this study. Both groups were subjected
to assessment of history, clinical examination, and laboratory investigations (erythrocyte
sedimentation rate, C-reactive protein titer, rheumatoid factor, HLA-B27). Conventional
radiography and MRI of the sacroiliac joints were performed. Spondyloarthropathic patients
were divided according to MRI as follows: group IIA, which included patients with sacroiliitis,
and group IIB, which included patients without sacroiliitis.
Results
In our study, ankylosing spondylitis was diagnosed in 22 (36.6%) patients, followed by
undifferentiated spondyloarthropathy in 12 (20%) patients, reactive arthritis in 10 (16.7%)
patients, psoriatic arthropathy in 10 (16.7%) patients, and enteropathic arthropathy in six (10%)
patients. Evidence of sacroiliitis was found in 66.6% (40/60) of patients by MRI, which was
higher than the result obtained by plain radiography 20% (12/60). HLA-B27 positivity found
in 53.3% (32/60) of patients. There was a significant difference between the two groups in
HLA-B27 and radiological sacroiliitis; there was no sacroiliitis in the control group. MRI showed
sacroiliitis even in patients with no inflammatory back pain. There was a highly statistically
significant difference between patient subgroups in disease duration (P = 0.001) and primary
complaints and clinical sacroiliitis (P = 0.001).
Conclusion
MRI is the preferred modality in the detection of early sacroiliitis in spondyloarthropathy and
HLA-B27 positivity is a highly useful predictor of early sacroiliitis |
|---|---|
| ISSN: | 1110-161X 2090-3235 |
| DOI: | 10.4103/1110-161X.163946 |