Insecticide resistance in dengue vectors from hotspots in Selangor, Malaysia

Insecticide resistance in dengue vectors from hotspots in Selangor, Malaysia

In Malaysia, dengue remains a top priority disease and usage of insecticides is the main method for dengue vector control. Limited baseline insecticide resistance data in dengue hotspots has prompted us to conduct this study. The present study reports the use of a map on the insecticide susceptibili...

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Bibliographic Details
Published in:PLoS neglected tropical diseases Vol. 15; no. 3; p. e0009205
Main Authors: Rasli, Rosilawati, Cheong, Yoon Ling, Che Ibrahim, M Khairuddin, Farahininajua Fikri, Siti Futri, Norzali, Rusydi Najmuddin, Nazarudin, Nur Ayuni, Hamdan, Nur Fadillah, Muhamed, Khairul Asuad, Hafisool, Afiq Ahnaf, Azmi, Ruziyatul Aznieda, Ismail, Harith Aswad, Ali, Roziah, Ab Hamid, Nurulhusna, Taib, Mohd Zainuldin, Omar, Topek, Wasi Ahmad, Nazni, Lee, Han Lim
Format: Journal Article
Language:English
Published: United States Public Library of Science 01-03-2021
Public Library of Science (PLoS)
Subjects:
Acetates
Acetic acid
Aquatic insects
Biological research
Biology and Life Sciences
Biology, Experimental
Buffer solutions
Chemical activity
Control
Control programs
Dengue
Dengue fever
Enzymes
Human diseases
Humidity
Insecticide resistance
Insecticides
Laboratories
Medical research
Medicine and Health Sciences
Mortality
Mosquitoes
Pesticide resistance
pH effects
Phosphates
Physical Sciences
Prevention
Residential areas
Sodium
Sodium acetate
Testing
Tropical diseases
Vector control
Vector-borne diseases
Vectors
Malaysia
Selangor Malaysia
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Summary:In Malaysia, dengue remains a top priority disease and usage of insecticides is the main method for dengue vector control. Limited baseline insecticide resistance data in dengue hotspots has prompted us to conduct this study. The present study reports the use of a map on the insecticide susceptibility status of Aedes aegypti and Aedes albopictus to provide a quick visualization and overview of the distribution of insecticide resistance. The insecticide resistance status of Aedes populations collected from 24 dengue hotspot areas from the period of December 2018 until June 2019 was proactively monitored using the World Health Organization standard protocol for adult and larval susceptibility testing was conducted, together with elucidation of the mechanisms involved in observed resistance. For resistance monitoring, susceptibility to three adulticides (permethrin, deltamethrin, and malathion) was tested, as well as susceptibility to the larvicide, temephos. Data showed significant resistance to both deltamethrin and permethrin (pyrethroid insecticides), and to malathion (organophosphate insecticide) in all sampled Aedes aegypti populations, while variable resistance patterns were found in the sampled Aedes albopictus populations. Temephos resistance was observed when larvae were tested using the diagnostic dosage of 0.012mg/L but not at the operational dosage of 1mg/L for both species. The present study highlights evidence of a potential threat to the effectiveness of insecticides currently used in dengue vector control, and the urgent requirement for insecticide resistance management to be integrated into the National Dengue Control Program.
Bibliography:The authors have declared that there is no competing interests exist.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0009205