Search Results - "Hambrook, Jacob R"

Immune Evasion Strategies of Schistosomes by Hambrook, Jacob R, Hanington, Patrick C

“…Human schistosomes combat the unique immune systems of two vastly different hosts during their indirect life cycles. In gastropod molluscs, they face a potent…”
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A cercarial invadolysin interferes with the host immune response and facilitates infection establishment of Schistosoma mansoni by Hambrook, Jacob R, Hanington, Patrick C

“…Schistosoma mansoni employs immune evasion and immunosuppression to overcome immune responses mounted by its snail and human hosts. Myriad immunomodulating…”
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Coordination of humoral immune factors dictates compatibility between Schistosoma mansoni and Biomphalaria glabrata by Li, Hongyu, Hambrook, Jacob R, Pila, Emmanuel A, Gharamah, Abdullah A, Fang, Jing, Wu, Xinzhong, Hanington, Patrick

“…Immune factors in snails of the genus are critical for combating , the predominant cause of human intestinal schistosomiasis. Independently, many of these…”
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A metalloprotease produced by larval Schistosoma mansoni facilitates infection establishment and maintenance in the snail host by interfering with immune cell function by Hambrook, Jacob R, Kaboré, Alèthe L, Pila, Emmanuel A, Hanington, Patrick C

“…Metalloproteases (MPs) have demonstrated roles in immune modulation. In some cases, these enzymes are produced by parasites to influence host immune responses…”
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Schistosomiasis from a Snail’s Perspective: Advances in Snail Immunity by Pila, Emmanuel A., Li, Hongyu, Hambrook, Jacob R., Wu, Xinzhong, Hanington, Patrick C.

“…The snail’s immune response is an important determinant of schistosome infection success, acting in concert with host, parasite, and environmental factors…”
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Single-cell RNA-seq profiling of individual Biomphalaria glabrata immune cells with a focus on immunologically relevant transcripts by Li, Hongyu, Gharamah, Abdullah A., Hambrook, Jacob R., Wu, Xinzhong, Hanington, Patrick C.

“…The immune cells of the snail Biomphalaria glabrata are classified into hyalinocyte and granulocyte subtypes. Both subtypes are essential for the proper…”
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Sasanquasaponin ΙΙΙ from Schima crenata Korth induces autophagy through Akt/mTOR/p70S6K pathway and promotes apoptosis in human melanoma A375 cells by Liang, Qiu-Ping, Xu, Tian-Qi, Liu, Bai-Lian, Lei, Xue-Ping, Hambrook, Jacob R., Zhang, Dong-Mei, Zhou, Guang-Xiong

“…Melanoma is a high fatality skin cancer which lacks effective drugs. Sasanquasaponin, an important sort of constituents in theaceae, has been demonstrated to…”
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Biomphalaria glabrata Granulin Increases Resistance to Schistosoma mansoni Infection in Several Biomphalaria Species and Induces the Production of Reactive Oxygen Species by Haemocytes by Hambrook, Jacob R, Gharamah, Abdullah A, Pila, Emmanuel A, Hussein, Solomon, Hanington, Patrick C

“…Gastropod molluscs, which have co-evolved with parasitic digenean trematodes for millions of years, utilize circulating heamocytes as the primary method of…”
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