Search Results - "Hamanaka, Robert"

Particulate Matter Air Pollution: Effects on the Cardiovascular System by Hamanaka, Robert B, Mutlu, Gökhan M

“…Air pollution is a complex mixture of gaseous and particulate components, each of which has detrimental effects on human health. While the composition of air…”
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Targeting glucose metabolism for cancer therapy by Hamanaka, Robert B, Chandel, Navdeep S

“…Cellular transformation is associated with the reprogramming of cellular pathways that control proliferation, survival, and metabolism. Among the metabolic…”
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Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes by Hamanaka, Robert B., Chandel, Navdeep S.

“…Reactive oxygen species (ROS) have historically been viewed as toxic metabolic byproducts and causal agents in a myriad of human pathologies. More recent work,…”
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Mitochondrial Complex III ROS Regulate Adipocyte Differentiation by Tormos, Kathryn V., Anso, Elena, Hamanaka, Robert B., Eisenbart, James, Joseph, Joy, Kalyanaraman, Balaraman, Chandel, Navdeep S.

“…Adipocyte differentiation is characterized by an increase in mitochondrial metabolism. However, it is not known whether the increase in mitochondrial…”
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Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism by Hamanaka, Robert B., Mutlu, Gökhan M.

“…Fibrosis is a pathologic condition characterized by excessive deposition of extracellular matrix and chronic scaring that can affect every organ system. Organ…”
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Mitochondrial reactive oxygen species regulate hypoxic signaling by Hamanaka, Robert B, Chandel, Navdeep S

“…Physiological hypoxia results in a host of responses that include increased ventilation, constriction of the pulmonary artery, and a cellular transcriptional…”
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Warburg Effect and Redox Balance by Hamanaka, Robert B., Chandel, Navdeep S.

“…A glycolytic enzyme maintains cellular redox homeostasis during metabolic stress. In the 1920s, German biochemist Otto Warburg demonstrated that tumor cells…”
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The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production by myofibroblasts: implications for organ fibrosis and cancer by Hamanaka, Robert B., Mutlu, Gökhan M.

“…Fibrosis is a pathologic condition resulting from aberrant wound healing responses that lead to excessive accumulation of extracellular matrix components,…”
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Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis by Wheaton, William W, Weinberg, Samuel E, Hamanaka, Robert B, Soberanes, Saul, Sullivan, Lucas B, Anso, Elena, Glasauer, Andrea, Dufour, Eric, Mutlu, Gokhan M, Budigner, Gr Scott, Chandel, Navdeep S

“…Recent epidemiological and laboratory-based studies suggest that the anti-diabetic drug metformin prevents cancer progression. How metformin diminishes tumor…”
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The role of nuclear lamin B1 in cell proliferation and senescence by Shimi, Takeshi, Butin-Israeli, Veronika, Adam, Stephen A, Hamanaka, Robert B, Goldman, Anne E, Lucas, Catherine A, Shumaker, Dale K, Kosak, Steven T, Chandel, Navdeep S, Goldman, Robert D

“…Nuclear lamin B1 (LB1) is a major structural component of the nucleus that appears to be involved in the regulation of many nuclear functions. The results of…”
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Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome by Mutlu, Ece A., Comba, Işın Y., Cho, Takugo, Engen, Phillip A., Yazıcı, Cemal, Soberanes, Saul, Hamanaka, Robert B., Niğdelioğlu, Recep, Meliton, Angelo Y., Ghio, Andrew J., Budinger, G.R. Scott, Mutlu, Gökhan M.

“…Recent studies suggest an association between particulate matter (PM) air pollution and gastrointestinal (GI) disease. In addition to direct deposition, PM can…”
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Loss of heme oxygenase 2 causes reduced expression of genes in cardiac muscle development and contractility and leads to cardiomyopathy in mice by Cetin-Atalay, Rengul, Meliton, Angelo Y, Ozcan, Cevher, Woods, Parker S, Sun, Kaitlyn A, Fang, Yun, Hamanaka, Robert B, Mutlu, Gökhan M

“…Obstructive sleep apnea (OSA) is a common breathing disorder that affects a significant portion of the adult population. In addition to causing excessive…”
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Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts by Hamanaka, Robert B, O'Leary, Erin M, Witt, Leah J, Tian, Yufeng, Gökalp, Gizem A, Meliton, Angelo Y, Dulin, Nickolai O, Mutlu, Gökhan M

“…Idiopathic pulmonary fibrosis (IPF) is characterized by the transforming growth factor (TGF)-β-dependent differentiation of lung fibroblasts into…”
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Our Compliments to the Authors: Decay Accelerating Factor and the Complement System in Pulmonary Fibrosis by Hamanaka, Robert B, Mutlu, Gökhan M

“…Hamanka and Mutlu discuss the study by Vittal et al which presents evidence that decay accelerating factor (DAF), a negative regulator of C3 complexes, is an…”
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PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes by Hamanaka, Robert B., Mutlu, Gökhan M.

“…p63 is a transcription factor essential for epidermal development and homeostasis. p63 is a member of the p53 family of transcription factors, which are…”
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Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation by Woods, Parker S, Kimmig, Lucas M, Meliton, Angelo Y, Sun, Kaitlyn A, Tian, Yufeng, O'Leary, Erin M, Gökalp, Gizem A, Hamanaka, Robert B, Mutlu, Gökhan M

“…Macrophage effector function is dynamic in nature and largely dependent on not only the type of immunological challenge but also the tissue-specific…”
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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity by Weinberg, Frank, Hamanaka, Robert, Wheaton, William W, Weinberg, Samuel, Joseph, Joy, Lopez, Marcos, Kalyanaraman, Balaraman, Mutlu, Gökhan M, Budinger, G.R. Scott, Chandel, Navdeep S

“…Otto Warburg's theory on the origins of cancer postulates that tumor cells have defects in mitochondrial oxidative phosphorylation and therefore rely on high…”
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HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium by Wu, David, Huang, Ru-Ting, Hamanaka, Robert B, Krause, Matt, Oh, Myung-Jin, Kuo, Cheng-Hsiang, Nigdelioglu, Recep, Meliton, Angelo Y, Witt, Leah, Dai, Guohao, Civelek, Mete, Prabhakar, Nanduri R, Fang, Yun, Mutlu, Gökhan M

“…Hemodynamic forces regulate vascular functions. Disturbed flow (DF) occurs in arterial bifurcations and curvatures, activates endothelial cells (ECs), and…”
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The Airway Epithelial Response to Air Pollution: It's Not Just Inflammation by Hamanaka, Robert B, Mutlu, Gökhan M

“…Hamanaka and Mutlu discuss the study by Montgomery and colleagues on the airway epithelial response to air pollution. The investigators used…”
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Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production by Nigdelioglu, Recep, Hamanaka, Robert B., Meliton, Angelo Y., O'Leary, Erin, Witt, Leah J., Cho, Takugo, Sun, Kaitlyn, Bonham, Catherine, Wu, David, Woods, Parker S., Husain, Aliya N., Wolfgeher, Don, Dulin, Nickolai O., Chandel, Navdeep S., Mutlu, Gökhan M.

“…TGF-β promotes excessive collagen deposition in fibrotic diseases such as idiopathic pulmonary fibrosis (IPF). The amino acid composition of collagen is unique…”
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