Search Results - "Hamanaka, R B"

PERK-dependent regulation of IAP translation during ER stress by Hamanaka, R B, Bobrovnikova-Marjon, E, Ji, X, Liebhaber, S A, Diehl, J A

“…Exposure of cells to endoplasmic reticulum (ER) stress leads to activation of phosphatidylinositol 3-kinase (PI3K)–Akt signaling pathway and transcriptional…”
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C73 OXIDANTS: Reactive Oxygen Species Are Required For Metabolic Reprogramming In Endothelial Cells Following Loss Of Laminar Shear Stress by Wu, D D, Huang, R-T, Hamanaka, R B, Witt, L J, Meliton, A Y, Fang, Y, Mutlu, G M

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A74 REGULATORY MECHANISMS OF THE MOLECULAR PATHWAYS IN FIBROSIS: Activation Of Adenylyl Cyclase/camp Pathway Attenuates Tgf-β Transcriptional Response In Human Lung Fibroblasts Via Epac by Witt, L J, Ansbro, B, Nigdelioglu, R, Wu, D, Meliton, A Y, Woods, P S, Sun, K A, Dulin, N O, Hamanaka, R B, Mutlu, G M

“…Conclusions: Activation of the adenylyl cyclase/cAMP pathway attenuates TGF-ß-induced gene transcription in normal human lung fibroblasts. The beneficial…”
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C103 OUTDOOR AIR POLLUTION: EPIDEMIOLOGY AND MECHANISMS: Short-Term Acute Exposure Of Healthy Humans To Particulate Matter Induces Differential Gene Expression In Lung Immune Cells by Meliton, A Y, Cho, T, Hamanaka, R B, Nigdelioglu, R, Sun, K, Budinger, G S, Ghio, A J, Mutlu, G M

“…Conclusions: Short-term exposure to PM causes differential expression of genes in lung immune cells in healthy human subjects. In addition to increased…”
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C17 EMERGING MECHANISMS IN LUNG INJURY AND INFECTION: [Beta]2-Agonists Promote Influenza A-Induced Lung Injury Via Increased Il-6 Release From Alveolar Macrophages by Mutlu, G M, Morales-Nebreda, L, Soberanes, S, Hamanaka, R B, Chi, M, Nigdelioglu, R, Cho, T, Budinger, G S

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C30 ACUTE LUNG INJURY: CELL FUNCTION, SIGNALING AND STRETCH: Activation Of The â2-Adrenergic Receptors On Monocytes Negatively Regulates Their Recruitment To The Injured Lung by Morales-Nebreda, L, Hamanaka, R B, McQuattie-Pimentel, A, Chi, M, Soberanes, S, Nigdelioglu, R, Cho, T, Misharin, A V, Budinger, G S, Mutlu, G M

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C107 MITOCHONDRIA AND METABOLIC ALTERATIONS IN LUNG DISEASE: De Novo Serine/glycine Synthesis Is Required For Tgf-β-Induced Collagen Production In Human Lung Fibroblasts by Nigdelioglu, R, Hamanaka, R B, Meliton, A Y, O'Leary, E, Witt, L J, Sun, K, Woods, P S, Wu, D, Dulin, N O, Chandel, N S, Mutlu, G M

“…Inhibition of glycolysis or the de novo serine/glycine synthesis pathway attenuated collagen protein accumulation without effecting SMAD phosphorylation or…”
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B46 HEALTH EFFECTS OF AIR POLLUTION AND NANOPARTICLES: Estrogen Inhibits Particulate Matter-Induced Il-6 Response by Hamanaka, R B, Chiarella, S E, Cho, T, Nigdelioglu, R, Soberanes, S, Morales-Nebreda, L, Budinger, G S, Mutlu, G M

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Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis by Soberanes, Saul, Misharin, Alexander V., Jairaman, Amit, Morales-Nebreda, Luisa, McQuattie-Pimentel, Alexandra C., Cho, Takugo, Hamanaka, Robert B., Meliton, Angelo Y., Reyfman, Paul A., Walter, James M., Chen, Ching-I, Chi, Monica, Chiu, Stephen, Gonzalez-Gonzalez, Francisco J., Antalek, Matthew, Abdala-Valencia, Hiam, Chiarella, Sergio E., Sun, Kaitlyn A., Woods, Parker S., Ghio, Andrew J., Jain, Manu, Perlman, Harris, Ridge, Karen M., Morimoto, Richard I., Sznajder, Jacob I., Balch, William E., Bhorade, Sangeeta M., Bharat, Ankit, Prakriya, Murali, Chandel, Navdeep S., Mutlu, Gökhan M., Budinger, G.R. Scott

“…Urban particulate matter air pollution induces the release of pro-inflammatory cytokines including interleukin-6 (IL-6) from alveolar macrophages, resulting in…”
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PERK and GCN2 Contribute to eIF2α Phosphorylation and Cell Cycle Arrest after Activation of the Unfolded Protein Response Pathway by Hamanaka, Robert B., Bennett, Beth S., Cullinan, Sara B., Diehl, J. Alan

“…Exposure of cells to endoplasmic reticulum (ER) stress leads to activation of PKR-like ER kinase (PERK), eukaryotic translation initiation factor 2α (eIF2α)…”
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