Search Results - "Hamamura, Kengo"

Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis by Yoshida, Yuya, Matsunaga, Naoya, Nakao, Takaharu, Hamamura, Kengo, Kondo, Hideaki, Ide, Tomomi, Tsutsui, Hiroyuki, Tsuruta, Akito, Kurogi, Masayuki, Nakaya, Michio, Kurose, Hitoshi, Koyanagi, Satoru, Ohdo, Shigehiro

“…Dysfunction of the circadian clock has been implicated in the pathogenesis of cardiovascular disease. The CLOCK protein is a core molecular component of the…”
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Administering xCT Inhibitors Based on Circadian Clock Improves Antitumor Effects by Okazaki, Fumiyasu, Matsunaga, Naoya, Hamamura, Kengo, Suzuki, Kayoko, Nakao, Takaharu, Okazaki, Hiroyuki, Kutsukake, Masahiko, Fukumori, Shiro, Tsuji, Yasuhiro, To, Hideto

“…Clock genes encoding transcription factors that regulate circadian rhythms may inform chronomodulated chemotherapy, where time-dependent dose alterations might…”
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Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design by Yokoo, Hidetomo, Shibata, Norihito, Endo, Akinori, Ito, Takahito, Yanase, Yuta, Murakami, Yuki, Fujii, Kiyonaga, Hamamura, Kengo, Saeki, Yasushi, Naito, Mikihiko, Aritake, Kosuke, Demizu, Yosuke

“…Targeted protein degradation by proteolysis-targeting chimera (PROTAC) is one of the exciting modalities for drug discovery and biological discovery. It is…”
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Efficacy of Essential Oils in Relieving Cancer Pain: A Systematic Review and Meta-Analysis by Corasaniti, Maria Tiziana, Bagetta, Giacinto, Morrone, Luigi Antonio, Tonin, Paolo, Hamamura, Kengo, Hayashi, Takafumi, Guida, Francesca, Maione, Sabatino, Scuteri, Damiana

“…Over 80% of patients affected by cancer develops cancer-related pain, one of the most feared consequences because of its intractable nature, particularly in…”
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Transgenic Mice for the Translational Study of Neuropathic Pain and Dystonia by Scuteri, Damiana, Hamamura, Kengo, Watanabe, Chizuko, Tonin, Paolo, Bagetta, Giacinto, Corasaniti, Maria Tiziana

“…Murine models are fundamental in the study of clinical conditions and the development of new drugs and treatments. Transgenic technology has started to offer…”
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Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent by Rombolà, Laura, Scuteri, Damiana, Watanabe, Chizuko, Sakurada, Shinobu, Hamamura, Kengo, Sakurada, Tsukasa, Tonin, Paolo, Corasaniti, Maria Tiziana, Bagetta, Giacinto, Morrone, Luigi Antonio

“…The essential oil obtained by the fresh fruit of Risso et Poiteau is used worldwide in aromatherapy to reduce pain, facilitate sleep induction, and/or minimize…”
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Behavioral Effects of Continuously Administered Bergamot Essential Oil on Mice With Partial Sciatic Nerve Ligation by Hamamura, Kengo, Katsuyama, Soh, Komatsu, Takaaki, Scuteri, Damiana, Bagetta, Giacinto, Aritake, Kosuke, Sakurada, Tsukasa

“…Neuropathic pain is an intractable chronic pain condition that is mainly caused by allodynia. We had previously reported that intra-plantar administration of…”
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24-Hour Rhythm of Aquaporin-3 Function in the Epidermis Is Regulated by Molecular Clocks by Matsunaga, Naoya, Itcho, Kazufumi, Hamamura, Kengo, Ikeda, Eriko, Ikeyama, Hisako, Furuichi, Yoko, Watanabe, Miyako, Koyanagi, Satoru, Ohdo, Shigehiro

“…Aquaporin 3 (AQP3) is located in the basal layer of the epidermis and regulates biological functions of skin such as water content and trans-epidermal water…”
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Hematopoietic Prostaglandin D Synthase Is Increased in Mast Cells and Pericytes in Autopsy Myocardial Specimens from Patients with Duchenne Muscular Dystrophy by Hamamura, Kengo, Yoshida, Yuya, Oyama, Kosuke, Li, Junhao, Kawano, Shimpei, Inoue, Kimiko, Toyooka, Keiko, Yamadera, Misaki, Matsunaga, Naoya, Matsumura, Tsuyoshi, Aritake, Kosuke

“…The leading cause of death for patients with Duchenne muscular dystrophy (DMD), a progressive muscle disease, is heart failure. Prostaglandin (PG) D , a…”
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Efficacy of Essential Oils in Pain: A Systematic Review and Meta-Analysis of Preclinical Evidence by Scuteri, Damiana, Hamamura, Kengo, Sakurada, Tsukasa, Watanabe, Chizuko, Sakurada, Shinobu, Morrone, Luigi Antonio, Rombolà, Laura, Tonin, Paolo, Bagetta, Giacinto, Corasaniti, Maria Tiziana

“…The demand for essential oils (EOs) has been steadily growing over the years. This is mirrored by a substantial increase in research concerned with EOs also in…”
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Analgesic Characteristics of NanoBEO Released by an Airless Dispenser for the Control of Agitation in Severe Dementia by Scuteri, Damiana, Rombolà, Laura, Hayashi, Takafumi, Watanabe, Chizuko, Sakurada, Shinobu, Hamamura, Kengo, Sakurada, Tsukasa, Tonin, Paolo, Bagetta, Giacinto, Morrone, Luigi A, Corasaniti, Maria Tiziana

“…Chronic pain is one of the most common causes of the need for clinical evaluation, acquiring more importance in the elderly with cognitive impairment. Reduced…”
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Prostaglandin F2α Affects the Cycle of Clock Gene Expression and Mouse Behavior by Tsurudome, Yuya, Yoshida, Yuya, Hamamura, Kengo, Ogino, Takashi, Yasukochi, Sai, Yasuo, Shinobu, Iwamoto, Ayaka, Yoshihara, Tatsuya, Inazumi, Tomoaki, Tsuchiya, Soken, Takeo, Toru, Nakagata, Naomi, Higuchi, Shigekazu, Sugimoto, Yukihiko, Tsuruta, Akito, Koyanagi, Satoru, Matsunaga, Naoya, Ohdo, Shigehiro

“…Prostaglandins are bioactive compounds, and the activation of their receptors affects the expression of clock genes. However, the prostaglandin F receptor ( )…”
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Possible involvement of the peripheral Mu-opioid system in antinociception induced by bergamot essential oil to allodynia after peripheral nerve injury by Komatsu, Takaaki, Katsuyama, Soh, Uezono, Yasuhito, Sakurada, Chikai, Tsuzuki, Minoru, Hamamura, Kengo, Bagetta, Giacinto, Sakurada, Shinobu, Sakurada, Tsukasa

“…•Intraplantar injection of BEO attenuates allodynia induced by PSNL.•Intraplantar injection of BEO inhibits ERK activation induced by PSNL in the lumbar dorsal…”
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Clinical and Market Analysis of NanoBEO: A Public-Worth, Innovative Therapy for Behavioral and Psychological Symptoms of Dementia (BPSD)-Emerging Evidence and Its Implications for a Health Technology Assessment (HTA) and Decision-Making in National Health Systems by Scuteri, Damiana, Pierobon, Daniele, Pagliaro, Martina, Hamamura, Kengo, Hayashi, Takafumi, Pignolo, Loris, Nicotera, Pierluigi, Bagetta, Giacinto, Corasaniti, Maria Tiziana

“…According to scientific literature, some 99% of patients affected by Alzheimer's disease (AD) suffer from behavioral and psychological symptoms of dementia…”
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Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression by Okazaki, Fumiyasu, Matsunaga, Naoya, Okazaki, Hiroyuki, Azuma, Hiroki, Hamamura, Kengo, Tsuruta, Akito, Tsurudome, Yuya, Ogino, Takashi, Hara, Yukinori, Suzuki, Takuya, Hyodo, Kenji, Ishihara, Hiroshi, Kikuchi, Hiroshi, To, Hideto, Aramaki, Hironori, Koyanagi, Satoru, Ohdo, Shigehiro

“…Iron is an important biological catalyst and is critical for DNA synthesis during cell proliferation. Cellular iron uptake is enhanced in tumor cells to…”
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Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches by Kusunose, Naoki, Tsuruta, Akito, Hamamura, Kengo, Tsurudome, Yuya, Yoshida, Yuya, Akamine, Takahiro, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro

“…The expression levels of many cell‐surface proteins vary with the time of day. Glycoprotein 2 (Gp2), specifically expressed on the apical surface of M cells in…”
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Preclinical Characterization of Antinociceptive Effect of Bergamot Essential Oil and of Its Fractions for Rational Translation in Complementary Therapy by Scuteri, Damiana, Rombolà, Laura, Crudo, Michele, Watanabe, Chizuko, Mizoguchi, Hirokazu, Sakurada, Shinobu, Hamamura, Kengo, Sakurada, Tsukasa, Tonin, Paolo, Corasaniti, Maria Tiziana, Bagetta, Giacinto

“…Bergamot essential oil (BEO) is endowed with consistent and reproducible antinociceptive and anti-allodynic properties when administered via an inhalation…”
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Development and Translation of NanoBEO, a Nanotechnology-Based Delivery System of Bergamot Essential Oil Deprived of Furocumarins, in the Control of Agitation in Severe Dementia by Scuteri, Damiana, Cassano, Roberta, Trombino, Sonia, Russo, Rossella, Mizoguchi, Hirokazu, Watanabe, Chizuko, Hamamura, Kengo, Katsuyama, Soh, Komatsu, Takaaki, Morrone, Luigi Antonio, Rombolà, Laura, Adornetto, Annagrazia, Laganà, Annarita S, Corasaniti, Maria Tiziana, Tonin, Paolo, Sakurada, Shinobu, Sakurada, Tsukasa, Nicotera, Pierluigi, Bagetta, Giacinto

“…Dementia is one of the most common causes of disability worldwide characterized by memory loss, cognitive impairment, and behavioral and psychological symptoms…”
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Translational Value of the Transdermal Administration of Bergamot Essential Oil and of Its Fractions by Scuteri, Damiana, Rombolà, Laura, Crudo, Michele, Watanabe, Chizuko, Mizoguchi, Hirokazu, Sakurada, Shinobu, Hamamura, Kengo, Sakurada, Tsukasa, Morrone, Luigi Antonio, Tonin, Paolo, Bagetta, Giacinto, Corasaniti, Maria Tiziana

“…The essential oil of bergamot (BEO) has consistently proven antinociceptive and antiallodynic properties. Accordingly, the analgesic efficacy of the decolored…”
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Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction by Hamamura, Kengo, Matsunaga, Naoya, Ikeda, Eriko, Kondo, Hideaki, Ikeyama, Hisako, Tokushige, Kazutaka, Itcho, Kazufumi, Furuichi, Yoko, Yoshida, Yuya, Matsuda, Masaki, Yasuda, Kaori, Doi, Atsushi, Yokota, Yoshifumi, Amamoto, Toshiaki, Aramaki, Hironori, Irino, Yasuhiro, Koyanagi, Satoru, Ohdo, Shigehiro

“…Chronic kidney disease (CKD) is associated with an increase in serum retinol; however, the underlying mechanisms of this disorder are poorly characterized…”
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