Search Results - "Hamamura, Kazumasa"

Discovery of 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor by Miwa, Kazuhiro, Hitaka, Takenori, Imada, Takashi, Sasaki, Satoshi, Yoshimatsu, Mie, Kusaka, Masami, Tanaka, Akira, Nakata, Daisuke, Furuya, Shuichi, Endo, Satoshi, Hamamura, Kazumasa, Kitazaki, Tomoyuki

“…We previously discovered an orally active human gonadotropin-releasing hormone (GnRH) receptor antagonist, thieno[2,3-d]pyrimidine-2,4-dione derivative 1…”
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Design, synthesis, and biological evaluation of 4-phenylpyrrole derivatives as novel androgen receptor antagonists by Yamamoto, Satoshi, Matsunaga, Nobuyuki, Hitaka, Takenori, Yamada, Masami, Hara, Takahito, Miyazaki, Junichi, Santou, Takashi, Kusaka, Masami, Yamaoka, Masuo, Kanzaki, Naoyuki, Furuya, Shuichi, Tasaka, Akihiro, Hamamura, Kazumasa, Ito, Mitsuhiro

“…A series of 4-phenylpyrrole derivatives were designed, synthesized, and evaluated for their potential as novel orally available androgen receptor antagonists…”
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Efficient syntheses of a novel 5-thia-1-azacycl[3.3.2]azine ring system and 3H-1,4-diazacycl[3.3.2]azine derivatives by Kawamoto, Tetsuji, Tomimatsu, Kiminori, Ikemoto, Tomomi, Abe, Hidenori, Hamamura, Kazumasa, Takatani, Muneo

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Large-scale synthesis of new cyclazines, 5-thia-1,8b-diazaacenaphthylene-3-carboxylic acid derivatives having the peripheral 12π-electron ring system by Ikemoto, Tomomi, Kawamoto, Tetsuji, Wada, Hiroki, Ishida, Toru, Ito, Tatsuya, Isogami, Yasushi, Miyano, Yoshiko, Mizuno, Yukio, Tomimatsu, Kiminori, Hamamura, Kazumasa, Takatani, Muneo, Wakimasu, Mitsuhiro

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Large-scale synthesis of new cyclazines, 5-thia-1,8 b-diazaacenaphthylene-3-carboxylic acid derivatives having the peripheral 12π-electron ring system by Ikemoto, Tomomi, Kawamoto, Tetsuji, Wada, Hiroki, Ishida, Toru, Ito, Tatsuya, Isogami, Yasushi, Miyano, Yoshiko, Mizuno, Yukio, Tomimatsu, Kiminori, Hamamura, Kazumasa, Takatani, Muneo, Wakimasu, Mitsuhiro

“…The 5-thia-1,8b-diazaacenaphthylenes ( 2 and its ester, 8 ) are new cyclazines, in which a paramagnetic ring is present in the peripheral 12π-electron ring…”
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Efficient syntheses of a novel 5-thia-1-azacycl[3.3.2]azine ring system and 3 H-1,4-diazacycl[3.3.2]azine derivatives by Kawamoto, Tetsuji, Tomimatsu, Kiminori, Ikemoto, Tomomi, Abe, Hidenori, Hamamura, Kazumasa, Takatani, Muneo

“…Novel 5-thia-1-azacycl[3.3.2]azine derivatives 1, 5-thia-1,8b-diazaacenaphthylenes, have successfully been prepared. An X-ray crystallographic analysis of 1c…”
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