Development of a PET/Cerenkov‐light hybrid imaging system

Purpose: Cerenkov‐light imaging is a new molecular imaging technology that detects visible photons from high‐speed electrons using a high sensitivity optical camera. However, the merit of Cerenkov‐light imaging remains unclear. If a PET/Cerenkov‐light hybrid imaging system were developed, the merit...

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Bibliographic Details
Published in:	Medical physics (Lancaster) Vol. 41; no. 9; pp. 092504 - n/a
Main Authors:	Yamamoto, Seiichi, Hamamura, Fuka, Watabe, Tadashi, Ikeda, Hayato, Kanai, Yasukazu, Watabe, Hiroshi, Kato, Katsuhiko, Ogata, Yoshimune, Hatazawa, Jun
Format:	Journal Article
Language:	English
Published:	United States American Association of Physicists in Medicine 01-09-2014
Subjects:	60 APPLIED LIFE SCIENCES Animals Biological material, e.g. blood, urine; Haemocytometers biomedical optical imaging Brain CAMERAS CCD image sensors Cerenkov‐light imaging Charge coupled imagers CHARGE-COUPLED DEVICES CHERENKOV COUNTING COMPARATIVE EVALUATIONS Digital computing or data processing equipment or methods, specially adapted for specific applications Electron multipliers Equipment Design eye Eye - anatomy & histology Eye - diagnostic imaging FLUORINE 18 Fluorodeoxyglucose F18 Harderian Gland - anatomy & histology Harderian Gland - diagnostic imaging hybrid imaging system Image analysis Image data processing or generation, in general Image detection systems image fusion Image quality Imaging detectors and sensors light absorption light transmission Measuring half‐life of a radioactive substance medical image processing Models, Biological Molecular Imaging - instrumentation Molecular Imaging - methods Optical Imaging - instrumentation Optical Imaging - methods PET Phantoms, Imaging Photodetectors (including infrared and CCD detectors) photomultipliers Photomultipliers; phototubes and photocathodes Photons Position sensitive detectors positron POSITRON COMPUTED TOMOGRAPHY positron emission tomography Positron emission tomography (PET) Positron-Emission Tomography - instrumentation Positron-Emission Tomography - methods Positrons Radiopharmaceuticals RATS Rats, Nude Scintigraphy SENSITIVITY Signal-To-Noise Ratio Sodium SODIUM 22 SPATIAL RESOLUTION Transforming light or analogous information into electric information
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Summary:	Purpose: Cerenkov‐light imaging is a new molecular imaging technology that detects visible photons from high‐speed electrons using a high sensitivity optical camera. However, the merit of Cerenkov‐light imaging remains unclear. If a PET/Cerenkov‐light hybrid imaging system were developed, the merit of Cerenkov‐light imaging would be clarified by directly comparing these two imaging modalities. Methods: The authors developed and tested a PET/Cerenkov‐light hybrid imaging system that consists of a dual‐head PET system, a reflection mirror located above the subject, and a high sensitivity charge coupled device (CCD) camera. The authors installed these systems inside a black box for imaging the Cerenkov‐light. The dual‐head PET system employed a 1.2 × 1.2 × 10 mm3 GSO arranged in a 33 × 33 matrix that was optically coupled to a position sensitive photomultiplier tube to form a GSO block detector. The authors arranged two GSO block detectors 10 cm apart and positioned the subject between them. The Cerenkov‐light above the subject is reflected by the mirror and changes its direction to the side of the PET system and is imaged by the high sensitivity CCD camera. Results: The dual‐head PET system had a spatial resolution of ∼1.2 mm FWHM and sensitivity of ∼0.31% at the center of the FOV. The Cerenkov‐light imaging systemˈs spatial resolution was ∼275μm for a 22Na point source. Using the combined PET/Cerenkov‐light hybrid imaging system, the authors successfully obtained fused images from simultaneously acquired images. The image distributions are sometimes different due to the light transmission and absorption in the body of the subject in the Cerenkov‐light images. In simultaneous imaging of rat, the authors found that 18F‐FDG accumulation was observed mainly in the Harderian gland on the PET image, while the distribution of Cerenkov‐light was observed in the eyes. Conclusions: The authors conclude that their developed PET/Cerenkov‐light hybrid imaging system is useful to evaluate the merits and the limitations of Cerenkov‐light imaging in molecular imaging research.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0094-2405 2473-4209
DOI:	10.1118/1.4893535