NDM-2 carbapenemase-producing Acinetobacter baumannii in the United Arab Emirates

Screening 155 carbapenem non-susceptible Acinetobacter baumannii strains recovered in Abu Dhabi hospitals identified two metallo-ß-lactamase blaNDM gene-carrying isolates. They were isolated 4 months apart from the urine of a cancer patient previously treated in Egypt, Lebanon and in the United Arab...

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Bibliographic Details
Published in:	Clinical microbiology and infection Vol. 18; no. 2; pp. E34 - E36
Main Authors:	Ghazawi, A., Sonnevend, Á., Bonnin, R.A., Poirel, L., Nordmann, P., Hashmey, R., Rizvi, T.A., Hamadeh, M. B, Pál, T.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Elsevier Ltd 01-02-2012 Blackwell Publishing Ltd Elsevier Limited
Subjects:	Acinetobacter Acinetobacter baumannii Acinetobacter baumannii - drug effects Acinetobacter baumannii - enzymology Acinetobacter baumannii - isolation & purification Acinetobacter Infections - microbiology Bacterial Proteins - genetics Bacterial Proteins - secretion beta-Lactam Resistance beta-Lactamases - genetics beta-Lactamases - secretion carbapenemase Carbapenems Carbapenems - pharmacology DNA, Bacterial - chemistry DNA, Bacterial - genetics Enterobacteriaceae Female Genotype Hospitals Humans Middle Aged Middle East Molecular Sequence Data Molecular Typing multidrug resistant NDM-2 Neoplasms - complications Sequence Analysis, DNA United Arab Emirates Urine Urine - microbiology United Arab Emirates Middle East Acinetobacter carbapenemase multidrug resistant NDM-2
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Summary:	Screening 155 carbapenem non-susceptible Acinetobacter baumannii strains recovered in Abu Dhabi hospitals identified two metallo-ß-lactamase blaNDM gene-carrying isolates. They were isolated 4 months apart from the urine of a cancer patient previously treated in Egypt, Lebanon and in the United Arab Emirates. They were clonally related and carried the blaNDM-2 gene recently identified in A. baumannii in Egypt and Israel. Sequences surrounding the blaNDM-2 gene showed significant similarities with those associated with blaNDM-1 in Enterobacteriaceae and A. baumannii. Repeated isolation of blaNDM-2-positive A. baumannii in the Middle East raises the possibility of the local emergence and spread of a unique clone.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1198-743X 1469-0691
DOI:	10.1111/j.1469-0691.2011.03726.x