Search Results - "Hamadeh, Hisham K."

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development by Morgan, Ryan E, van Staden, Carlo J, Chen, Yuan, Kalyanaraman, Natarajan, Kalanzi, Jackson, Dunn, 2nd, Robert T, Afshari, Cynthia A, Hamadeh, Hisham K

“…The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it serves as the primary route of elimination for monovalent bile…”
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The integration of pharmacophore-based 3D QSAR modeling and virtual screening in safety profiling: A case study to identify antagonistic activities against adenosine receptor, A2A, using 1,897 known drugs by Fan, Fan, Toledo Warshaviak, Dora, Hamadeh, Hisham K, Dunn, 2nd, Robert T

“…Safety pharmacology screening against a wide range of unintended vital targets using in vitro assays is crucial to understand off-target interactions with drug…”
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Perturbation of microRNAs in rat heart during chronic doxorubicin treatment by Vacchi-Suzzi, Caterina, Bauer, Yasmina, Berridge, Brian R, Bongiovanni, Sandrine, Gerrish, Kevin, Hamadeh, Hisham K, Letzkus, Martin, Lyon, Jonathan, Moggs, Jonathan, Paules, Richard S, Pognan, François, Staedtler, Frank, Vidgeon-Hart, Martin P, Grenet, Olivier, Couttet, Philippe

“…Anti-cancer therapy based on anthracyclines (DNA intercalating Topoisomerase II inhibitors) is limited by adverse effects of these compounds on the…”
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Genome-scale metabolic model of the rat liver predicts effects of diet restriction by Baloni, Priyanka, Sangar, Vineet, Yurkovich, James T., Robinson, Max, Taylor, Scott, Karbowski, Christine M., Hamadeh, Hisham K., He, Yudong D., Price, Nathan D.

“…Mapping network analysis in cells and tissues can provide insights into metabolic adaptations to changes in external environment, pathological conditions, and…”
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Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital by Ueda, Akiko, Hamadeh, Hisham K, Webb, Heather K, Yamamoto, Yukio, Sueyoshi, Tatsuya, Afshari, Cynthia A, Lehmann, Jürgen M, Negishi, Masahiko

“…Phenobarbital (PB) induces various gene encoding drug/steroid-metabolizing enzymes such as cytochromes P450 (P450s) and transferases. Although the nuclear…”
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Identification of Putative Gene-Based Markers of Renal Toxicity by Amin, Rupesh P., Vickers, Alison E., Sistare, Frank, Thompson, Karol L., Roman, Richard J., Lawton, Michael, Kramer, Jeffrey, Hamadeh, Hisham K., Collins, Jennifer, Grissom, Sherry, Bennett, Lee, Tucker, C. Jeffrey, Wild, Stacie, Kind, Clive, Oreffo, Victor, Davis, John W., Curtiss, Sandra, Naciff, Jorge M., Cunningham, Michael, Tennant, Raymond, Stevens, James, Car, Bruce, Bertram, Timothy A., Afshari, Cynthia A.

“…This study, designed and conducted as part of the International Life Sciences Institute working group on the Application of Genomics and Proteomics, examined…”
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Common handling procedures conducted in preclinical safety studies result in minimal hepatic gene expression changes in Sprague-Dawley rats by He, Yudong D, Karbowski, Christine M, Werner, Jon, Everds, Nancy, Di Palma, Chris, Chen, Yuan, Higgins-Garn, Marnie, Tran, Sandra, Afshari, Cynthia A, Hamadeh, Hisham K

“…Gene expression profiling is a tool to gain mechanistic understanding of adverse effects in response to compound exposure. However, little is known about how…”
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Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development by Morgan, Ryan E., Trauner, Michael, van Staden, Carlo J., Lee, Paul H., Ramachandran, Bharath, Eschenberg, Michael, Afshari, Cynthia A., Qualls, Charles W., Lightfoot-Dunn, Ruth, Hamadeh, Hisham K.

“…The bile salt export pump (BSEP) is an efflux transporter, driving the elimination of endobiotic and xenobiotic substrates from hepatocytes into the bile. More…”
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A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity by Mongan, M Ann, Dunn, Robert T, Vonderfecht, Steven, Everds, Nancy, Chen, Guang, Su, Cheng, Higgins-Garn, Marnie, Chen, Yuan, Afshari, Cynthia A, Williamson, Toni L, Carlock, Linda, Dipalma, Christopher, Moss, Suzanne, Bussiere, Jeanine, Qualls, Charles, He, Yudong D, Hamadeh, Hisham K

“…Genome-wide gene expression profiling has become standard for assessing potential liabilities as well as for elucidating mechanisms of toxicity of drug…”
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Methapyrilene Toxicity: Anchorage of Pathologic Observations to Gene Expression Alterations by Hamadeh, Hisham K., Knight, Brian L., Haugen, Astrid C., Sieber, Stella, Amin, Rupesh P., Bushel, Pierre R., Stoll, Raymond, Blanchard, Kerry, Jayadev, Supriya, Tennant, Raymond W., Cunningham, Michael L., Afshari, Cynthia A., Paules, Richard S.

“…Methapyrilene (MP) exposure of animals can result in an array of adverse pathological responses including hepatotoxicity. This study investigates gene…”
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Challenges to Using Big Data in Cancer by Sweeney, Shawn M, Hamadeh, Hisham K, Abrams, Natalie, Adam, Stacey J, Brenner, Sara, Connors, Dana E, Davis, Gerard J, Fiore, Louis, Gawel, Susan H, Grossman, Robert L, Hanlon, Sean E, Hsu, Karl, Kelloff, Gary J, Kirsch, Ilan R, Louv, Bill, McGraw, Deven, Meng, Frank, Milgram, Daniel, Miller, Robert S, Morgan, Emily, Mukundan, Lata, O'Brien, Thomas, Robbins, Paul, Rubin, Eric H, Rubinstein, Wendy S, Salmi, Liz, Schaller, Teilo, Shi, George, Sigman, Caroline C, Srivastava, Sudhir

“…Big data in healthcare can enable unprecedented understanding of diseases and their treatment, particularly in oncology. These data may include electronic…”
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The evolution of bioinformatics in toxicology: advancing toxicogenomics by Afshari, Cynthia A, Hamadeh, Hisham K, Bushel, Pierre R

“…As one reflects back through the past 50 years of scientific research, a significant accomplishment was the advance into the genomic era. Basic research…”
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Cross-Site Comparison of Gene Expression Data Reveals High Similarity by Chu, Tzu-Ming, Deng, Shibing, Wolfinger, Russ, Paules, Richard S., Hamadeh, Hisham K.

“…Consistency and coherence of gene expression data across multiple sites depends on several factors such as platform (oligo, cDNA, etc.), environmental…”
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Case Studies for Overcoming Challenges in Using Big Data in Cancer by Sweeney, Shawn M, Hamadeh, Hisham K, Abrams, Natalie, Adam, Stacey J, Brenner, Sara, Connors, Dana E, Davis, Gerard J, Fiore, Louis D, Gawel, Susan H, Grossman, Robert L, Hanlon, Sean E, Hsu, Karl, Kelloff, Gary J, Kirsch, Ilan R, Louv, Bill, McGraw, Deven, Meng, Frank, Milgram, Daniel, Miller, Robert S, Morgan, Emily, Mukundan, Lata, O'Brien, Thomas, Robbins, Paul, Rubin, Eric H, Rubinstein, Wendy S, Salmi, Liz, Schaller, Teilo H, Shi, George, Sigman, Caroline C, Srivastava, Sudhir

“…The analysis of big healthcare data has enormous potential as a tool for advancing oncology drug development and patient treatment, particularly in the context…”
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Assessment of repeated microarray experiments using mixed tissue RNA reference samples by Mongan, M Ann, Mongan, Ann, Higgins, Marnie, Pine, P Scott, Pine, Scott, Afshari, Cynthia, Hamadeh, Hisham

“…Genome-scale gene expression technologies are increasingly being applied for biological research as a whole and toxicological screening in particular. In order…”
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A systematic assessment of mitochondrial function identified novel signatures for drug-induced mitochondrial disruption in cells by Li, Nianyu, Oquendo, Elisa, Capaldi, Roderick A, Robinson, J Paul, He, Yudong D, Hamadeh, Hisham K, Afshari, Cynthia A, Lightfoot-Dunn, Ruth, Narayanan, Padma Kumar

“…Mitochondrial perturbation has been recognized as a contributing factor to various drug-induced organ toxicities. To address this issue, we developed a…”
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Oxidative stress and its role in skin disease by Trouba, Kevin J, Hamadeh, Hisham K, Amin, Rupesh P, Germolec, Dori R

“…Skin is a major target of oxidative stress due to reactive oxygen species (ROS) that originate in the environment and in the skin itself. ROS are generated…”
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Gene Expression Analysis Reveals Chemical-Specific Profiles by Hamadeh, Hisham K., Bushel, Pierre R., Jayadev, Supriya, Martin, Karla, DiSorbo, Olimpia, Sieber, Stella, Bennett, Lee, Tennant, Raymond, Stoll, Raymond, Barrett, J. Carl, Blanchard, Kerry, Paules, Richard S., Afshari, Cynthia A.

“…The application of gene expression profiling technology to examine multiple genes and signaling pathways simultaneously promises a significant advance in…”
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Prediction of Compound Signature Using High Density Gene Expression Profiling by Hamadeh, Hisham K., Bushel, Pierre R., Jayadev, Supriya, DiSorbo, Olimpia, Bennett, Lee, Li, Leping, Tennant, Raymond, Stoll, Raymond, Barrett, J. Carl, Paules, Richard S., Blanchard, Kerry, Afshari, Cynthia A.

“…DNA microarrays, used to measure the gene expression of thousands of genes simultaneously, hold promise for future application in efficient screening of…”
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Application of Genomics for Identification of Systemic Toxicity Triggers Associated With VEGF-R Inhibitors by Hamadeh, Hisham K, Todd, Marque, Healy, Laura, Meyer, James T, Kwok, Annie M, Higgins, Marnie, Afshari, Cynthia A

“…The key to the discovery of new pharmaceuticals is to develop molecules that interact with the intended target and minimize interaction with unintended…”
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