Search Results - "Hamada, Yoji"

Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity by Ishikawa, Kota, Tsunekawa, Shin, Ikeniwa, Makoto, Izumoto, Takako, Iida, Atsushi, Ogata, Hidetada, Uenishi, Eita, Seino, Yusuke, Ozaki, Nobuaki, Sugimura, Yoshihisa, Hamada, Yoji, Kuroda, Akio, Shinjo, Keiko, Kondo, Yutaka, Oiso, Yutaka

“…Recent studies have implicated epigenetics in the pathophysiology of diabetes. Furthermore, DNA methylation, which irreversibly deactivates gene transcription,…”
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Chronic high-sucrose diet increases fibroblast growth factor 21 production and energy expenditure in mice by Maekawa, Ryuya, Seino, Yusuke, Ogata, Hidetada, Murase, Masatoshi, Iida, Atsushi, Hosokawa, Kaori, Joo, Erina, Harada, Norio, Tsunekawa, Shin, Hamada, Yoji, Oiso, Yutaka, Inagaki, Nobuya, Hayashi, Yoshitaka, Arima, Hiroshi

“…Excess carbohydrate intake causes obesity in humans. On the other hand, acute administration of fructose, glucose or sucrose in experimental animals has been…”
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Medical treatment of diabetic neuropathy by Hamada, Yoji

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Transplantation of Bone Marrow–Derived Mesenchymal Stem Cells Improves Diabetic Polyneuropathy in Rats by SHIBATA, Taiga, NARUSE, Keiko, NAKASHIMA, Eitaro, HAMADA, Yoji, OISO, Yutaka, NAKAMURA, Jiro, KAMIYA, Hideki, KOZAKAE, Mika, KONDO, Masaki, YASUDA, Yutaka, NAKAMURA, Nobuhisa, OTA, Kimiko, TOSAKI, Takahiro, MATSUKI, Takashi

“…Transplantation of Bone Marrow–Derived Mesenchymal Stem Cells Improves Diabetic Polyneuropathy in Rats Taiga Shibata 1 , Keiko Naruse 1 2 , Hideki Kamiya 1 ,…”
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Beneficial Effects of Exendin-4 on Experimental Polyneuropathy in Diabetic Mice by HIMENO, Tatsuhito, KAMIYA, Hideki, FUKAMI, Ayako, HAMADA, Yoji, INAGAKI, Nobuya, SEINO, Yutaka, DRUCKER, Daniel J, OISO, Yutaka, NAKAMURA, Jiro, NARUSE, Keiko, HARADA, Norio, OZAKI, Nobuaki, SEINO, Yusuke, SHIBATA, Taiga, KONDO, Masaki, KATO, Jiro, OKAWA, Tetsuji

“…The therapeutic potential of exendin-4, an agonist of the glucagon-like peptide-1 receptor (GLP-1R), on diabetic polyneuropathy (DPN) in streptozotocin…”
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The role of S100B in the interaction between adipocytes and macrophages by Fujiya, Atsushi, Nagasaki, Hiroshi, Seino, Yusuke, Okawa, Tetsuji, Kato, Jiro, Fukami, Ayako, Himeno, Tatsuhito, Uenishi, Eita, Tsunekawa, Shin, Kamiya, Hideki, Nakamura, Jiro, Oiso, Yutaka, Hamada, Yoji

“…Objective The S100 calcium binding protein B (S100B) implicated in brain inflammation acts via the receptor of advanced glycation end products (RAGE) and is…”
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Mesenchymal stem cells ameliorate impaired wound healing through enhancing keratinocyte functions in diabetic foot ulcerations on the plantar skin of rats by Kato, Jiro, Kamiya, Hideki, Himeno, Tatsuhito, Shibata, Taiga, Kondo, Masaki, Okawa, Tetsuji, Fujiya, Atsushi, Fukami, Ayako, Uenishi, Eita, Seino, Yusuke, Tsunekawa, Shin, Hamada, Yoji, Naruse, Keiko, Oiso, Yutaka, Nakamura, Jiro

“…Abstract Aims/hypothesis Although the initial healing stage involves a re-epithelialization in humans, diabetic foot ulceration (DFU) has been investigated…”
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Effects of clozapine on adipokine secretions/productions and lipid droplets in 3T3-L1 adipocytes by Tsubai, Tomomi, Yoshimi, Akira, Hamada, Yoji, Nakao, Makoto, Arima, Hiroshi, Oiso, Yutaka, Noda, Yukihiro

“…Clozapine, a second-generation antipsychotic (SGA), is a cause of side effects related to metabolic syndrome. The participation of serotonin 5-HT2C and…”
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Dipeptidyl peptidase-4 inhibitor anagliptin reduces fasting apolipoprotein B-48 levels in patients with type 2 diabetes: A randomized controlled trial by Onoue, Takeshi, Goto, Motomitsu, Wada, Eri, Furukawa, Mariko, Okuji, Takayuki, Okada, Norio, Kobayashi, Tomoko, Iwama, Shintaro, Sugiyama, Mariko, Tsunekawa, Taku, Takagi, Hiroshi, Hagiwara, Daisuke, Ito, Yoshihiro, Morishita, Yoshiaki, Seino, Yusuke, Suga, Hidetaka, Banno, Ryoichi, Hamada, Yoji, Ando, Masahiko, Yamamori, Etsuko, Arima, Hiroshi

“…Type 2 diabetes and dyslipidemia are diseases that collectively increase the risk of patients developing cardiovascular complications. Several incretin-based…”
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KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state by Ogata, Hidetada, Seino, Yusuke, Harada, Norio, Iida, Atsushi, Suzuki, Kazuyo, Izumoto, Takako, Ishikawa, Kota, Uenishi, Eita, Ozaki, Nobuaki, Hayashi, Yoshitaka, Miki, Takashi, Inagaki, Nobuya, Tsunekawa, Shin, Hamada, Yoji, Seino, Susumu, Oiso, Yutaka

“…Glucose-dependent insulinotropic polypeptide (GIP), a gut hormone secreted from intestinal K-cells, potentiates insulin secretion. Both K-cells and pancreatic…”
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Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin by Iida, Atsushi, Seino, Yusuke, Fukami, Ayako, Maekawa, Ryuya, Yabe, Daisuke, Shimizu, Shinobu, Kinoshita, Keita, Takagi, Yusuke, Izumoto, Takako, Ogata, Hidetada, Ishikawa, Kota, Ozaki, Nobuaki, Tsunekawa, Shin, Hamada, Yoji, Oiso, Yutaka, Arima, Hiroshi, Hayashi, Yoshitaka

“…Aims/hypothesis The action of incretin hormones including glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) is potentiated…”
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Effect of hyperglycemia on hepatocellular carcinoma development in diabetes by Niwa, Yasuhiro, Ishikawa, Kota, Ishigami, Masatoshi, Honda, Takashi, Achiwa, Koichi, Izumoto, Takako, Maekawa, Ryuya, Hosokawa, Kaori, Iida, Atsushi, Seino, Yusuke, Hamada, Yoji, Goto, Hidemi, Oiso, Yutaka, Arima, Hiroshi, Tsunekawa, Shin

“…Compared with other cancers, diabetes mellitus is more closely associated with hepatocellular carcinoma (HCC). However, whether hyperglycemia is associated…”
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Functional adenosine triphosphate‐sensitive potassium channel is required in high‐carbohydrate diet‐induced increase in β‐cell mass by Murase, Masatoshi, Seino, Yusuke, Maekawa, Ryuya, Iida, Atsushi, Hosokawa, Kaori, Hayami, Tomohide, Tsunekawa, Shin, Hamada, Yoji, Yokoi, Norihide, Seino, Susumu, Hayashi, Yoshitaka, Arima, Hiroshi

“…Aims/Introduction A high‐carbohydrate diet is known to increase insulin secretion and induce obesity. However, whether or not a high‐carbohydrate diet affects…”
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The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic mice by Hamada, Yoji, Nagasaki, Hiroshi, Fuchigami, Masahiro, Furuta, Shinji, Seino, Yusuke, Nakamura, Jiro, Oiso, Yutaka

“…Abstract Objective Alpha-glucosidase inhibitors (α-GIs) show various anti-diabetic or anti-obesity effects in addition to the suppression of postprandial…”
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Transplantation of neural crest-like cells derived from induced pluripotent stem cells improves diabetic polyneuropathy in mice by Okawa, Tetsuji, Kamiya, Hideki, Himeno, Tatsuhito, Kato, Jiro, Seino, Yusuke, Fujiya, Atsushi, Kondo, Masaki, Tsunekawa, Shin, Naruse, Keiko, Hamada, Yoji, Ozaki, Nobuaki, Cheng, Zhao, Kito, Tetsutaro, Suzuki, Hirohiko, Ito, Sachiko, Oiso, Yutaka, Nakamura, Jiro, Isobe, Ken-Ichi

“…Impaired vascularity and nerve degeneration are the most important pathophysiological abnormalities of diabetic polyneuropathy (DPN). Therefore, regeneration…”
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Reduced NGF secretion by Schwann cells under the high glucose condition decreases neurite outgrowth of DRG neurons by Tosaki, Takahiro, Kamiya, Hideki, Yasuda, Yutaka, Naruse, Keiko, Kato, Koichi, Kozakae, Mika, Nakamura, Nobuhisa, Shibata, Taiga, Hamada, Yoji, Nakashima, Eitaro, Oiso, Yutaka, Nakamura, Jiro

“…Schwann cells (SCs) have been supposed to play prominent roles in axonal regeneration under various diseases. Here, to evaluate the direct interaction between…”
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Deceptive HbA1c in a patient with pure red cell aplasia by Okawa, Tetsuji, MD, Tsunekawa, Shin, Dr, Seino, Yusuke, MD, Hamada, Yoji, MD, Oiso, Yutaka, Prof

“…Despite additional treatment with long-term blood transfusions (but not recombinant human erythropoietin), her HbA1c remained high (8·0%). [...]the…”
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Fructose induces glucose‐dependent insulinotropic polypeptide, glucagon‐like peptide‐1 and insulin secretion: Role of adenosine triphosphate‐sensitive K+ channels by Seino, Yusuke, Ogata, Hidetada, Maekawa, Ryuya, Izumoto, Takako, Iida, Atsushi, Harada, Norio, Miki, Takashi, Seino, Susumu, Inagaki, Nobuya, Tsunekawa, Shin, Oiso, Yutaka, Hamada, Yoji

“…Adenosine triphosphate‐sensitive K+ (KATP) channels play an essential role in glucose‐induced insulin secretion from pancreatic β‐cells. It was recently…”
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The alpha-glucosidase inhibitor miglitol increases hepatic CYP7A1 activity in association with altered short-chain fatty acid production in the gut of obese diabetic mice by Hamada, Yoji, Goto, Moritaka, Nishimura, Go, Nagasaki, Hiroshi, Seino, Yusuke, Kamiya, Hideki, Nakamura, Jiro

“…Bile acids (BAs) have been shown to contribute to glucose and energy homeostasis. We have recently reported that miglitol, an alpha-glucosidase inhibitor,…”
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Mesenchymal Stem Cell-Like Cells Derived from Mouse Induced Pluripotent Stem Cells Ameliorate Diabetic Polyneuropathy in Mice by Kato, Jiro, Kito, Tetsutaro, Hamada, Yoji, Oiso, Yutaka, Isobe, Ken-ichi, Nakamura, Jiro, Fujiya, Atsushi, Okawa, Tetsuji, Kondo, Masaki, Ito, Sachiko, Cheng, Zhao, Naruse, Keiko, Kamiya, Hideki, Himeno, Tatsuhito, Suzuki, Hirohiko

“…Background. Although pathological involvements of diabetic polyneuropathy (DPN) have been reported, no dependable treatment of DPN has been achieved. Recent…”
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