Search Results - "Hamad, Mawieh"

High-Dose Deferoxamine Treatment Disrupts Intracellular Iron Homeostasis, Reduces Growth, and Induces Apoptosis in Metastatic and Nonmetastatic Breast Cancer Cell Lines by Bajbouj, Khuloud, Shafarin, Jasmin, Hamad, Mawieh

“…Mounting evidence suggest that iron overload enhances cancer growth and metastasis; hence, iron chelation is being increasingly used as part of the treatment…”
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Estrogen-induced epigenetic silencing of FTH1 and TFRC genes reduces liver cancer cell growth and survival by Muhammad, Jibran Sualeh, Bajbouj, Khuloud, Shafarin, Jasmin, Hamad, Mawieh

“…Estrogen (E2) regulates hundreds of genes involved in cell metabolism and disrupts iron homoeostasis in various cell types. Herein, we addressed whether…”
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JAK/STAT signaling and cellular iron metabolism in hepatocellular carcinoma: therapeutic implications by Rah, Bilal, Farhat, Nada Mazen, Hamad, Mawieh, Muhammad, Jibran Sualeh

“…Iron metabolism plays a crucial role in the development and progression of hepatocellular carcinoma (HCC), the most common type of primary liver cancer. Iron…”
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Fisetin Deters Cell Proliferation, Induces Apoptosis, Alleviates Oxidative Stress and Inflammation in Human Cancer Cells, HeLa by Afroze, Nazia, Pramodh, Sreepoorna, Shafarin, Jasmin, Bajbouj, Khuloud, Hamad, Mawieh, Sundaram, Madhumitha Kedhari, Haque, Shafiul, Hussain, Arif

“…Fisetin, a flavonol profusely found in vegetables and fruits, exhibited a myriad of properties in preclinical studies to impede cancer growth. This study was…”
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Universal fungal vaccines: Could there be light at the end of the tunnel? by Hamad, Mawieh

“…The complex nature of fungal pathogens, the intricate host-pathogen relationship and the health status of subjects in need of antifungal vaccination continue…”
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SARS-CoV-2 Infection-Induced Promoter Hypomethylation as an Epigenetic Modulator of Heat Shock Protein A1L (HSPA1L) Gene by Muhammad, Jibran Sualeh, Saheb Sharif-Askari, Narjes, Cui, Zheng-Guo, Hamad, Mawieh, Halwani, Rabih

“…Numerous researches have focused on the genetic variations affecting SARS-CoV-2 infection, whereas the epigenetic effects are inadequately described. In this…”
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Estrogen-induced hypomethylation and overexpression of YAP1 facilitate breast cancer cell growth and survival by Muhammad, Jibran Sualeh, Guimei, Maha, Jayakumar, Manju Nidagodu, Shafarin, Jasmin, Janeeh, Aisha Saleh, AbuJabal, Rola, Eladl, Mohamed Ahmed, Ranade, Anu Vinod, Ali, Amjad, Hamad, Mawieh

“…Increased expression of Yes-associated protein-1 (YAP1) was shown to correlate with reduced survival in breast cancer (BC) patients. However, the exact…”
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Protein arginine N-methyltransferase 5 in colorectal carcinoma: Insights into mechanisms of pathogenesis and therapeutic strategies by Abumustafa, Wafaa, Zamer, Batoul Abi, Khalil, Bariaa A., Hamad, Mawieh, Maghazachi, Azzam A., Muhammad, Jibran Sualeh

“…Protein arginine N-methyltransferase 5 (PRMT5) enzyme is one of the eight canonical PRMTs, classified as a type II PRMT, induces arginine monomethylation and…”
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Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic Donors by Taneera, Jalal, Huneidi, Waseem El, Hamad, Mawieh, Mohammed, Abdul Khader, Elaraby, Esraa, Hachim, Mahmood Yaseen

“…Cellular entry of SARS-CoV-2 is thought to occur through the binding of viral spike S1 protein to ACE2. The entry process involves priming of the S protein by…”
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Estrogen-induced disruption of intracellular iron metabolism leads to oxidative stress, membrane damage, and cell cycle arrest in MCF-7 cells by Bajbouj, Khuloud, Shafarin, Jasmin, Abdalla, Maher Y, Ahmad, Iman M, Hamad, Mawieh

“…It is well established that several forms of cancer associate with significant iron overload. Recent studies have suggested that estrogen (E2) disrupts…”
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Short-term exposure to interleukin-6 does not affect angiotensin-converting enzyme 2 expression in human pancreatic islets by Khalique, Anila, Hamad, Mawieh, Taneera, Jalal

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Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC by Ali, Amjad, Shafarin, Jasmin, Abu Jabal, Rola, Aljabi, Nour, Hamad, Mohamad, Sualeh Muhammad, Jibran, Unnikannan, Hema, Hamad, Mawieh

“…Overexpression of ferritin heavy chain (FTH1) often associates with good prognosis in breast cancer (BCa), particularly in the triple‐negative subtype…”
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Candida albicans PPG1, a serine/threonine phosphatase, plays a vital role in central carbon metabolisms under filament-inducing conditions: A multi-omics approach by A L Bataineh, Mohammad Tahseen, Soares, Nelson Cruz, Semreen, Mohammad Harb, Cacciatore, Stefano, Dash, Nihar Ranjan, Hamad, Mohamad, Mousa, Muath Khairi, Salam, Jasmin Shafarin Abdul, Al Gharaibeh, Mutaz F, Zerbini, Luiz F, Hamad, Mawieh

“…Candida albicans is the leading cause of life-threatening bloodstream candidiasis, especially among immunocompromised patients. The reversible morphological…”
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Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells by Bajbouj, Khuloud, Shafarin, Jasmin, Taneera, Jalal, Hamad, Mawieh

“…Previous work has shown that although estrogen (E2) disrupts cellular iron metabolism and induces oxidative stress in breast and ovarian cancer cells, it fails…”
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Iron Overload Induces Oxidative Stress, Cell Cycle Arrest and Apoptosis in Chondrocytes by Karim, Asima, Bajbouj, Khuloud, Shafarin, Jasmin, Qaisar, Rizwan, Hall, Andrew C, Hamad, Mawieh

“…Clinical and experimental evidence point to the presence of considerable links between arthropathy, osteoarthritis (OA) in particular, and iron overload…”
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Metformin enhances LDL-cholesterol uptake by suppressing the expression of the pro-protein convertase subtilisin/kexin type 9 (PCSK9) in liver cells by Ali, Amjad, Unnikannan, Hema, Shafarin, Jasmin, Bajbouj, Khuloud, Taneera, Jalal, Muhammad, Jibran Sualeh, Hasan, Haydar, Salehi, Albert, Awadallah, Samir, Hamad, Mawieh

“…Purpose Metformin (MF) intake associates with reduced levels of circulating low-density lipoprotein-cholesterol (LDL-C). This has been attributed to the…”
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Evaluating deposited radiation energy amount and collision quantities of small-molecule radiosensitizers through Monte Carlo simulations by ALMisned, Ghada, Kilic, Ceyda Sibel, Almansoori, Asma, Mesbahi, A., Hamad, Mawieh, Tekin, H.O.

“…This study investigates the photon interaction mechanism of various small molecule radiosensitizers, including Hydrogen Peroxide, Nimorazole, 5-Fluorouracil,…”
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Genetic Mutations and Non-Coding RNA-Based Epigenetic Alterations Mediating the Warburg Effect in Colorectal Carcinogenesis by Abi Zamer, Batoul, Abumustafa, Wafaa, Hamad, Mawieh, Maghazachi, Azzam A., Muhammad, Jibran Sualeh

“…Colorectal cancer (CRC) development is a gradual process defined by the accumulation of numerous genetic mutations and epigenetic alterations leading to the…”
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Novel Secreted Peptides From Rhizopus arrhizus var. delemar With Immunomodulatory Effects That Enhance Fungal Pathogenesis by Soliman, Sameh S M, El-Labbad, Eman M, Abu-Qiyas, Ameera, Fayed, Bahgat, Hamoda, Alshaimaa M, Al-Rawi, Ahmed M, Dakalbab, Salam, El-Shorbagi, Abdel-Nasser A, Hamad, Mawieh, Ibrahim, Ashraf S, Mohammad, Mohammad G

“…Secreted fungal peptides are known to influence the interactions between the pathogen and host innate immunity. The aim of this study is to screen and evaluate…”
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PRMT5 Mediated HIF1α Signaling and Ras-Related Nuclear Protein as Promising Biomarker in Hepatocellular Carcinoma by Abumustafa, Wafaa, Castven, Darko, Sharif-Askari, Fatemeh Saheb, Abi Zamer, Batoul, Hamad, Mawieh, Marquardt, Jens-Uwe, Muhammad, Jibran Sualeh

“…Protein arginine N-methyltransferase 5 (PRMT5) has been identified as a potential therapeutic target for various cancer types. However, its role in regulating…”
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