Search Results - "Hama, Susumu"

Overcoming the polyethylene glycol dilemma via pathological environment-sensitive change of the surface property of nanoparticles for cellular entry by Hama, Susumu, Itakura, Shoko, Nakai, Mayumi, Nakayama, Kayoko, Morimoto, Satoshi, Suzuki, Satoko, Kogure, Kentaro

“…Modification with polyethylene glycol (PEG) is currently considered an important strategy for anti-cancer drug delivery, because PEGylated-nanoparticles would…”
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Anti-cancer vaccination by transdermal delivery of antigen peptide-loaded nanogels via iontophoresis by Toyoda, Mao, Hama, Susumu, Ikeda, Yutaka, Nagasaki, Yukio, Kogure, Kentaro

“…[Display omitted] Transdermal vaccination with cancer antigens is expected to become a useful anti-cancer therapy. However, it is difficult to accumulate…”
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Low Electric Treatment activates Rho GTPase via Heat Shock Protein 90 and Protein Kinase C for Intracellular Delivery of siRNA by Hasan, Mahadi, Hama, Susumu, Kogure, Kentaro

“…Low electric treatment (LET) promotes intracellular delivery of naked siRNA by altering cellular physiology. However, which signaling molecules and cellular…”
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Tocopheryl Phosphate Inhibits Rheumatoid Arthritis-Related Gene Expression In Vitro and Ameliorates Arthritic Symptoms in Mice by Hama, Susumu, Kirimura, Naoko, Obara, Aki, Takatsu, Hirokatsu, Kogure, Kentaro

“…Anti-rheumatoid arthritis (RA) effects of α-tocopherol (α-T) have been shown in human patients in a double-blind trial. However, the effects of α-T and its…”
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Scavenging of Hydroxyl Radicals in Aqueous Solution by Astaxanthin Encapsulated in Liposomes by Hama, Susumu, Uenishi, Sachiko, Yamada, Asako, Ohgita, Takashi, Tsuchiya, Hiroyuki, Yamashita, Eiji, Kogure, Kentaro

“…Astaxanthin (Asx) is known to be a potent quencher of singlet oxygen and an efficient scavenger of superoxide anion. Therefore, Asx would be expected to be a…”
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Resistin affects lipid metabolism during adipocyte maturation of 3T3‐L1 cells by Ikeda, Yoshito, Tsuchiya, Hiroyuki, Hama, Susumu, Kajimoto, Kazuaki, Kogure, Kentaro

“…Resistin, an adipose‐tissue‐specific secretory factor, aggravates metabolic syndrome through impairment of glucose metabolism. Previously, we demonstrated that…”
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Prevention of UV-Induced Melanin Production by Accumulation of Redox Nanoparticles in the Epidermal Layer via Iontophoresis by Shiota, Kanako, Hama, Susumu, Yoshitomi, Toru, Nagasaki, Yukio, Kogure, Kentaro

“…UV rays induce melanin production in the skin, which, from a cosmetic point of view, is problematic. Reactive oxygen species (ROS) generated in the skin upon…”
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Intraperitoneal administration of nanoparticles containing tocopheryl succinate prevents peritoneal dissemination by Hama, Susumu, Nishi, Takayuki, Isono, Eitaro, Itakura, Shoko, Yoshikawa, Yutaka, Nishimoto, Akinori, Suzuki, Satoko, Kirimura, Naoko, Todo, Hiroaki, Kogure, Kentaro

“…Intraperitoneal administration of anticancer nanoparticles is a rational strategy for preventing peritoneal dissemination of colon cancer due to the prolonged…”
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High-fat, high-fructose diet induces hepatic iron overload via a hepcidin-independent mechanism prior to the onset of liver steatosis and insulin resistance in mice by Tsuchiya, Hiroyuki, Ebata, Yu, Sakabe, Tomohiko, Hama, Susumu, Kogure, Kentaro, Shiota, Goshi

“…Abstract Objective Excess iron deposition in tissues leads to increased oxidative stress. The clinical observation that non-alcoholic fatty liver disease…”
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Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet-induced skin damage by Hama, Susumu, Takahashi, Kanako, Inai, Yuko, Shiota, Kanako, Sakamoto, Ryota, Yamada, Asako, Tsuchiya, Hiroyuki, Kanamura, Kiyoshi, Yamashita, Eiji, Kogure, Kentaro

“…Astaxanthin (Asx) would be expected to prevent ultraviolet (UV)-induced skin damage, as it is regarded as a potent antioxidative carotenoid in biological…”
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Rapid modification of antibodies on the surface of liposomes composed of high-affinity protein A-conjugated phospholipid for selective drug delivery by Hama, Susumu, Sakai, Mika, Itakura, Shoko, Majima, Eiji, Kogure, Kentaro

“…Antibody-modified liposomes, immuno-liposomes, can selectively deliver encapsulated drug ‘cargos’ to cells via the interaction of cell surface proteins with…”
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Nanoparticles Consisting of Tocopheryl Succinate Are a Novel Drug-Delivery System with Multifaceted Antitumor Activity by Hama, Susumu, Kogure, Kentaro

“…Tumor heterogeneity hampers the clinical efficacy of cancer chemotherapy. Therefore, it is necessary to develop a multifaceted, rational treatment strategy…”
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Synergistic antioxidative effect of astaxanthin and tocotrienol by co-encapsulated in liposomes by Kamezaki, Chihiro, Nakashima, Ami, Yamada, Asako, Uenishi, Sachiko, Ishibashi, Hiroshi, Shibuya, Natsumi, Hama, Susumu, Hosoi, Shinzo, Yamashita, Eiji, Kogure, Kentaro

“…Astaxanthin and vitamin E are both effective antioxidants that are frequently used in cosmetics, as food additives, and in to prevent oxidative damage. A…”
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Resistin regulates the expression of plasminogen activator inhibitor-1 in 3T3-L1 adipocytes by Ikeda, Yoshito, Tsuchiya, Hiroyuki, Hama, Susumu, Kajimoto, Kazuaki, Kogure, Kentaro

“…•We investigated the relationship between expression of resistin and PAI-1.•PAI-1 expression was significantly decreased by resistin knockdown.•PAI-1…”
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Development of a Novel Nanocarrier Focusing on the Physicochemical Properties of an Anti-cancer Therapy Drug —Development of Anti-cancer Nanoparticles Containing Vitamin E Derivative with Mulitifaceted Anti-cancer Effect by Hama, Susumu

“…Successful cancer gene therapy is dependent upon the development of nanocarriers that exhibit anti-cancer effects via delivery of nucleic acids to the target…”
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Development of nanoparticles incorporating a novel liposomal membrane destabilization peptide for efficient release of cargos into cancer cells by Itakura, Shoko, Hama, Susumu, Ohgita, Takashi, Kogure, Kentaro

“…In anti-cancer therapy mediated by a nanoparticle-based drug delivery system (DDS), overall efficacy depends on the release efficiency of cargos from the…”
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Carotenoid Stereochemistry Affects Antioxidative Activity of Liposomes Co-encapsulating Astaxanthin and Tocotrienol by Ishikawa, Misuzu, Hirai, Shota, Yoshida, Tatsusada, Shibuya, Natsumi, Hama, Susumu, Takahashi, Yu, Fukuta, Tatsuya, Tanaka, Tamotsu, Hosoi, Shinzo, Kogure, Kentaro

“…We previously found that antioxidative activity of liposomes co-encapsulating astaxanthin (Asx) and tocotrienols (T3s) was higher than the calculated additive…”
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A novel effector secretion mechanism based on proton‐motive force‐dependent type III secretion apparatus rotation by Ohgita, Takashi, Hayashi, Naoki, Hama, Susumu, Tsuchiya, Hiroyuki, Gotoh, Naomasa, Kogure, Kentaro

“…The type III secretion apparatus (T3SA) participates in the secretion of bacterial proteins called effectors, although the detailed mechanism of effector…”
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Effective capture of proteins inside living cells by antibodies indirectly linked to a novel cell‐penetrating polymer‐modified protein A derivative by Itakura, Shoko, Hama, Susumu, Ikeda, Hisafumi, Mitsuhashi, Naoto, Majima, Eiji, Kogure, Kentaro

“…Antibodies against cytoplasmic proteins are useful tools that can control cellular function and clarify signaling mechanisms. However, it is difficult to…”
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Peroxisome Proliferator-Activated Receptor γ (PPARγ)-Independent Specific Cytotoxicity against Immature Adipocytes Induced by PPARγ Antagonist T0070907 by Kawahara, Arisa, Haraguchi, Naoko, Tsuchiya, Hiroyuki, Ikeda, Yoshito, Hama, Susumu, Kogure, Kentaro

“…Peroxisome proliferator-activated receptor γ (PPARγ) plays indispensable roles in adipogenesis, which is frequently impaired under pathological conditions such…”
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