Antioxidant activity of condensed [1,2,4-triazinone derivatives in nitrosative stress

Antioxidant activity of nine [1,2,4]-triazinone derivatives was studied in the work. Our data show that [1,2,4]-triazinone derivatives with benzyl alcohol, propyl alcohol, me-thyl alcohol and tolyl residues in their structure have antioxidant activity in condition of in vitro NO formation. KO-17 com...

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Bibliographic Details
Published in:	Ukrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 79; no. 5; p. 159
Main Authors:	Hubs'kyĭ, Iu I, Belenichev, I F, Levyts'kyĭ, Ie L, Halytsia, V V, Bukhtiiarova, N V, Kovalenko, S I, Babenko, L P, Zadoryna, O V
Format:	Journal Article
Language:	Ukrainian
Published:	Ukraine 01-09-2007
Subjects:	Animals Antioxidants - chemistry Antioxidants - pharmacology Brain - drug effects Brain - enzymology Brain - metabolism In Vitro Techniques Male Models, Chemical Molecular Structure Nitric Oxide - chemistry Nitric Oxide Donors - chemistry Oxidative Stress - drug effects Rats Rats, Wistar Structure-Activity Relationship Superoxide Dismutase - metabolism Triazines - chemistry Triazines - pharmacology
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Summary:	Antioxidant activity of nine [1,2,4]-triazinone derivatives was studied in the work. Our data show that [1,2,4]-triazinone derivatives with benzyl alcohol, propyl alcohol, me-thyl alcohol and tolyl residues in their structure have antioxidant activity in condition of in vitro NO formation. KO-17 compound proved to have the greatest antioxidant activity which exceeded N-acetyl cysteine's one.