Search Results - "Halwani Rabih"
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Intranasal administration of abatacept enhances IL-35+ and IL-10+ producing Bregs in lung tissues of ovalbumin-sensitized asthmatic mice model
Published in PloS one (06-09-2022)“…Backgrounds Treating asthmatic rheumatoid arthritis patients with abatacept has been shown to associate with better control of asthma symptoms. However, the…”
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2
Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19
Published in Frontiers in immunology (30-06-2021)“…More than one year since its emergence, corona virus disease 2019 (COVID-19) is still looming large with a paucity of treatment options. To add to this burden,…”
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Prevalence and predictors of Post-Acute COVID-19 Syndrome (PACS) after hospital discharge: A cohort study with 4 months median follow-up
Published in PloS one (07-12-2021)“…Post-acute COVID-19 syndrome (PACS) is an emerging healthcare burden. The risk factors associated with PACS remain largely unclear. The aim of this study was…”
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4
Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD
Published in Molecular therapy. Methods & clinical development (11-09-2020)“…It has been reported that angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are the main cell entry proteins for severe…”
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Glucocorticoid Receptor-Beta Up-Regulation and Steroid Resistance Induction by IL-17 and IL-23 Cytokine Stimulation in Peripheral Mononuclear Cells
Published in Journal of clinical immunology (01-02-2013)“…Purpose Most asthmatic patients have well controlled symptoms with regular treatment, but some require much higher doses of inhaled and oral corticosteroids,…”
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Editorial: Dysregulation of immunity predisposing to severe COVID-19 infection
Published in Frontiers in immunology (02-12-2022)Get full text
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The psychological impact of the COVID-19 pandemic on adults and children in the United Arab Emirates: a nationwide cross-sectional study
Published in BMC psychiatry (03-05-2021)“…The psychosocial impact of previous infectious disease outbreaks in adults has been well documented, however, there is limited information on the mental health…”
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Abatacept enhances blood regulatory B cells of rheumatoid arthritis patients to a level that associates with disease remittance
Published in Scientific reports (11-03-2021)“…Abatacept, an inhibitor of CD28 mediated T-cell activation, has been shown to be effective in controlling inflammation during rheumatoid arthritis (RA)…”
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9
Vitamin D regulates COVID-19 associated severity by suppressing the NLRP3 inflammasome pathway
Published in PloS one (15-05-2024)“…The role of vitamin D3 (VitD3) in modulating innate and adaptive immunity has been reported in different disease contexts. Since the start of the coronavirus…”
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Early administration of remdesivir to COVID-19 patients associates with higher recovery rate and lower need for ICU admission: A retrospective cohort study
Published in PloS one (26-10-2021)“…Remdesivir is one of the most widely recommended and used medications for COVID-19 treatment. However, different outcomes have been reported for hospitalized…”
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11
JAK Inhibitor Therapy in a Child with Inherited USP18 Deficiency
Published in The New England journal of medicine (16-01-2020)“…A neonate with a loss-of-function mutation in USP18 and exuberant expression of interferon-stimulated genes was experimentally treated with ruxolitinib, which…”
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SARS-CoV-2 Switches 'on' MAPK and NFκB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression
Published in Frontiers in pharmacology (20-04-2021)“…Mitogen-activated protein kinases (MAPK) and NF-kappaB (NF-κB) pathway regulate many cellular processes and are essential for immune cells function. Their…”
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13
Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Explicitly in SARS-CoV-2 Infected Lung Epithelial Cells
Published in Frontiers in immunology (10-06-2020)“…Current guidelines for COVID-19 management recommend the utilization of various repurposed drugs. Despite ongoing research toward the development of a vaccine…”
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SARS-CoV-2 Infection-Induced Promoter Hypomethylation as an Epigenetic Modulator of Heat Shock Protein A1L (HSPA1L) Gene
Published in Frontiers in genetics (19-02-2021)“…Numerous researches have focused on the genetic variations affecting SARS-CoV-2 infection, whereas the epigenetic effects are inadequately described. In this…”
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Parental Attitudes and Hesitancy About COVID-19 vs. Routine Childhood Vaccinations: A National Survey
Published in Frontiers in public health (13-10-2021)“…Objectives: To quantify parental acceptance of the COVID-19 vaccine and assess the vaccine hesitancy (VH) for COVID-19 vs. childhood vaccines. Methods: Eight…”
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COVID-19 vaccine confidence and hesitancy among health care workers: A cross-sectional survey from a MERS-CoV experienced nation
Published in PloS one (29-11-2021)“…Objectives This study aimed to identify coronavirus disease 2019 (COVID-19) vaccine perception, acceptance, confidence, hesitancy, and barriers among health…”
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Nucleic acid sensor STING drives remodeling and its inhibition enhances steroid responsiveness in chronic obstructive pulmonary disease
Published in PloS one (05-07-2023)“…Chronic obstructive pulmonary disease (COPD) is progressive and irreversible chronic lung inflammatory disease. Cigarette smoke, the main cause of COPD, is…”
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Enhanced mitophagy in bronchial fibroblasts from severe asthmatic patients
Published in PloS one (30-11-2020)“…Sub-epithelial fibrosis is a characteristic feature of airway remodeling in asthma which correlates with disease severity. Current asthma medications are…”
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Nirmatrelvir plus ritonavir reduces COVID-19 hospitalization and prevents long COVID in adult outpatients
Published in Scientific reports (29-10-2024)“…Nirmatrelvir plus ritonavir received Emergency Use Authorization for treating mild to moderate COVID-19 in high-risk patients. Its efficacy against the Omicron…”
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Specific targeting and noninvasive imaging of breast cancer stem cells using single-walled carbon nanotubes as novel multimodality nanoprobes
Published in Nanomedicine (London, England) (01-01-2016)“…The limitation of current breast cancer treatments was elucidated by the presence of cancer stem cells (CSCs) that play essential role in cancer initiation,…”
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