Search Results - "Halsey, Sheelagh"
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Continuous Manufacturing of High Quality Pharmaceutical Cocrystals Integrated with Process Analytical Tools for In-Line Process Control
Published in Crystal growth & design (01-06-2016)“…A continuous manufacturing process for pharmaceutical indomethacin–saccharine cocrystals was achieved by extrusion processing with high throughput. Down-stream…”
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Implementation of transmission NIR as a PAT tool for monitoring drug transformation during HME processing
Published in European journal of pharmaceutics and biopharmaceutics (01-10-2015)“…[Display omitted] •Implementation of PAT tools for process understanding and quality control.•NIR transmission and reflectance probes are used for first time…”
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Continuous Cocrystallization for Dissolution Rate Optimization of a Poorly Water-Soluble Drug
Published in Crystal growth & design (02-01-2014)“…A continuous manufacturing process, hot melt extrusion (HME), was employed for the development of high quality carbamazepine–saccharin (CBZ–SCH) cocrystals…”
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Prediction of polymorphic transformations of paracetamol in solid dispersions
Published in Journal of pharmaceutical sciences (01-06-2014)“…A novel approach employing variable-temperature X-ray powder diffraction (VTXRPD) was used to exploit its suitability as an off-line predictive tool to study…”
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Development of sustained-release formulations processed by hot-melt extrusion by using a quality-by-design approach
Published in Drug delivery and translational research (01-08-2014)“…In this study, a quality-by-design (QbD) approach was used to optimize the development of paracetamol (PMOL) sustained-release formulations manufactured by…”
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Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion
Published in AAPS PharmSciTech (01-02-2016)“…The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM),…”
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Near infra red spectroscopy as a multivariate process analytical tool for predicting pharmaceutical co-crystal concentration
Published in Journal of pharmaceutical and biomedical analysis (10-09-2016)“…[Display omitted] •NIR spectroscopy can distinguish between the API, co-former and the co-crystal form.•Linear PLS regression models for two pharmaceutical…”
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NIR Raw Material Identification in the Pharmaceutical Industry; A Robust System or An Accident Waiting to Happen?
Published in NIR news (01-02-2009)Get full text
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Monitoring the Output of Pharmaceutical Hot Melt Extruders with near Infrared Spectroscopy
Published in NIR news (01-03-2014)Get full text
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