Search Results - "Halsey, Michaela K"
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Comparison of genetic variation between rare and common congeners of Dipodomys with estimates of contemporary and historical effective population size
Published in PloS one (13-09-2022)“…Species with low effective population sizes are at greater risk of extinction because of reduced genetic diversity. Such species are more vulnerable to chance…”
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Simultaneous TE Analysis of 19 Heliconiine Butterflies Yields Novel Insights into Rapid TE-Based Genome Diversification and Multiple SINE Births and Deaths
Published in Genome biology and evolution (01-08-2019)“…Abstract Transposable elements (TEs) play major roles in the evolution of genome structure and function. However, because of their repetitive nature, they are…”
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Evolution of the ancestral mammalian karyotype and syntenic regions
Published in Proceedings of the National Academy of Sciences - PNAS (04-10-2022)“…Decrypting the rearrangements that drive mammalian chromosome evolution is critical to understanding the molecular bases of speciation, adaptation, and disease…”
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A genomic timescale for placental mammal evolution
Published in Science (American Association for the Advancement of Science) (28-04-2023)“…The precise pattern and timing of speciation events that gave rise to all living placental mammals remain controversial. We provide a comprehensive…”
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Mammalian evolution of human cis-regulatory elements and transcription factor binding sites
Published in Science (American Association for the Advancement of Science) (28-04-2023)“…Understanding the regulatory landscape of the human genome is a long-standing objective of modern biology. Using the reference-free alignment across 241…”
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Relating enhancer genetic variation across mammals to complex phenotypes using machine learning
Published in Science (American Association for the Advancement of Science) (28-04-2023)“…Protein-coding differences between species often fail to explain phenotypic diversity, suggesting the involvement of genomic elements that regulate gene…”
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Three-dimensional genome rewiring in loci with human accelerated regions
Published in Science (American Association for the Advancement of Science) (28-04-2023)“…Human accelerated regions (HARs) are conserved genomic loci that evolved at an accelerated rate in the human lineage and may underlie human-specific traits. We…”
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The functional and evolutionary impacts of human-specific deletions in conserved elements
Published in Science (American Association for the Advancement of Science) (28-04-2023)“…Conserved genomic sequences disrupted in humans may underlie uniquely human phenotypic traits. We identified and characterized 10,032 human-specific conserved…”
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Chiropterans Are a Hotspot for Horizontal Transfer of DNA Transposons in Mammalia
Published in Molecular biology and evolution (02-05-2023)“…Abstract Horizontal transfer of transposable elements (TEs) is an important mechanism contributing to genetic diversity and innovation. Bats (order Chiroptera)…”
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Using evolutionary constraint to define novel candidate driver genes in medulloblastoma
Published in Proceedings of the National Academy of Sciences - PNAS (15-08-2023)“…Current knowledge of cancer genomics remains biased against noncoding mutations. To systematically search for regulatory noncoding mutations, we assessed…”
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Updated distribution of the Texas kangaroo rat (Dipodomys elator) and patterns of rodent species associations from county road surveys in Texas
Published in Therya (30-05-2023)Get full text
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