Search Results - "Hals, Ingrid"

A 1‐year pilot study of intralymphatic injections of GAD‐alum in individuals with latent autoimmune diabetes in adults (LADA) with signs of high immunity: No safety concerns and resemblance to juvenile type 1 diabetes by Hals, Ingrid K., Balasuriya, Chandima, Casas, Rosaura, Ludvigsson, Johnny, Björklund, Anneli, Grill, Valdemar

“…Aims To test, for the first time in latent autoimmune diabetes in adults (LADA), the effects of autoantigen‐specific immunotherapy by intralymphatic…”
Get full text

Latent Autoimmune Diabetes in Adults: Background, Safety and Feasibility of an Ongoing Pilot Study With Intra-Lymphatic Injections of GAD-Alum and Oral Vitamin D by Björklund, Anneli, Hals, Ingrid K., Grill, Valdemar, Ludvigsson, Johnny

“…BackgroundLatent Autoimmune Diabetes in Adults (LADA) constitutes around 10% of all diabetes. Many LADA patients gradually lose their insulin secretion and…”
Get full text

Time-dependent effects on circulating cytokines in patients with LADA: A decrease in IL1-ra and IL-1 beta is associated with progressive disease by Hals, Ingrid K, Björklund, Anneli, Fiskvik Fleiner, Hanne, Grill, Valdemar

“…•Longitudinal measurements of circulating cytokines in a LADA population.•High levels of GADA are a proxy for high autoimmune activity.•High levels of GADA…”
Get full text

Mitochondrial Respiration in Insulin-Producing β-Cells: General Characteristics and Adaptive Effects of Hypoxia by Hals, Ingrid K, Bruerberg, Simon Gustafson, Ma, Zuheng, Scholz, Hanne, Björklund, Anneli, Grill, Valdemar

“…To provide novel insights on mitochondrial respiration in β-cells and the adaptive effects of hypoxia. Insulin-producing INS-1 832/13 cells were exposed to 18…”
Get full text

Metabolic Outcomes in Adults Born Preterm With Very Low Birthweight or Small for Gestational Age at Term: A Cohort Study by Balasuriya, Chandima N D, Stunes, Astrid Kamilla, Mosti, Mats P, Schei, Berit, Indredavik, Marit S, Hals, Ingrid K, Evensen, Kari Anne I, Syversen, Unni

“…Low birthweight (LBW) has emerged as a risk factor of metabolic syndrome (MetS). Whether adults with very low birthweight (VLBW) born preterm are at higher…”
Get full text

Investigating optimal β‐cell‐preserving treatment in latent autoimmune diabetes in adults: Results from a 21‐month randomized trial by Hals, Ingrid K., Fiskvik Fleiner, Hanne, Reimers, Nina, Astor, Marianne C., Filipsson, Karin, Ma, Zuheng, Grill, Valdemar, Björklund, Anneli

“…Aims To compare outcomes of glucagon‐stimulated C‐peptide tests (GSCTs) in people with latent autoimmune diabetes in adults (LADA) after a 21‐month…”
Get full text

Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation by Wallin, Tina, Ma, Zuheng, Ogata, Hirotaka, Jørgensen, Ingrid Hals, Iezzi, Mariella, Wang, Haiyan, Wollheim, Claes B., Björklund, Anneli

“…Facilitation of fatty acid uptake in beta cells could potentially affect beta cell metabolism and secretory function; however such effects have not been…”
Get full text

Increased toxicity of amylin (Islet Amyloid Polypeptide) in beta cells induced by photochemical internalization by Rinku, Singh, Hals, Ingrid, Høgset, Anders, Grill, Valdemar, Gederaas, Odrun A.

“…•PCI technology can be a tool to induce endosomal rupture in clonal beta cells.•Exposure to human amylin and PCI together exerted toxic effects in beta…”
Get full text

Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic β-cells by Ma, Zuheng, Moruzzi, Noah, Catrina, Sergiu-Bogdan, Hals, Ingrid, Oberholzer, José, Grill, Valdemar, Björklund, Anneli

“…Beta cells of pancreatic islets are susceptible to functional deficits and damage by hypoxia. Here we aimed to characterize such effects and to test for and…”
Get full text

Marked over expression of uncoupling protein-2 in beta cells exerts minor effects on mitochondrial metabolism by Hals, Ingrid K., Ogata, Hirotaka, Pettersen, Elin, Ma, Zuheng, Björklund, Anneli, Skorpen, Frank, Egeberg, Kjartan Wollo, Grill, Valdemar

“…► The impact of UCP-2 over expression on mitochondrial function is controversial. ► We tested mitochondrial functions at defined levels of overexpression. ► We…”
Get full text

Culture at low glucose up-regulates mitochondrial function in pancreatic β cells with accompanying effects on viability by Hals, Ingrid K., Singh, Rinku, Ma, Zuheng, Scholz, Hanne, Björklund, Anneli, Grill, Valdemar

“…We tested whether exposure of β cells at reduced glucose leads to mitochondrial adaptions and whether such adaptions modulate effects of hypoxia. Rat islets,…”
Get full text

Uncoupling Protein-2 Participates in Cellular Defense against Oxidative Stress in Clonal β-Cells by Li, Li-Xin, Skorpen, Frank, Egeberg, Kjartan, Jørgensen, Ingrid Hals, Grill, Valdemar

“…The role of uncoupling protein-2 (UCP-2) in β-cells is presently unclear. We have tested the notion that UCP-2 participates in β-cell defense against oxidants…”
Get full text

Diabetes reduces β-cell mitochondria and induces distinct morphological abnormalities, which are reproducible by high glucose in vitro with attendant dysfunction by Ma, Zuheng, Wirström, Tina, Borg, L.A. Håkan, Larsson-Nyrén, Gerd, Hals, Ingrid, Bondo-Hansen, John, Grill, Valdemar, Björklund, Anneli

“…We investigated the impact of a diabetic state with hyperglycemia on morphometry of β cell mitochondria and modifying influence of a K + -ATP channel opener…”
Get full text

Comments on the notion of false positivity in measurements of autoantibodies by Grill, Valdemar, Sørgjerd, Elin, Hals, Ingrid, Carlsson, Sofia

Get full text

Letter to the Editor From Grill et al: “Islet Function and Insulin Sensitivity in Latent Autoimmune Diabetes in Adults Taking Sitagliptin: A Randomized Trial” by Grill, Valdemar, Bjorklund, Anneli, Hals, Ingrid

Get full text

Induction of Uncoupling Protein 2 mRNA in β-Cells Is Stimulated by Oxidation of Fatty Acids But Not by Nutrient Oversupply by Li, Li-Xin, Skorpen, Frank, Egeberg, Kjartan, Jørgensen, Ingrid Hals, Grill, Valdemar

“…We tested for regulation of uncoupling protein 2 (UCP-2) in β-cells in response to fatty acids and glucose. A 48-h culture with oleate (0.2 mm) at 5.5 or 11 mm…”
Get full text

Hvordan behandle LADA-diabetes? by Grill, Valdemar, Hals, Ingrid

Get full text

How to treat latent autoimmune diabetes? by Grill, Valdemar, Hals, Ingrid

Get full text

Mitochondrial Respiration in Insulin-Producing [beta]-Cells: General Characteristics and Adaptive Effects of Hypoxia by Hals, Ingrid K, Bruerberg, Simon Gustafson, Ma, Zuheng, Scholz, Hanne, Björklund, Anneli, Grill, Valdemar

“…Objective To provide novel insights on mitochondrial respiration in [beta]-cells and the adaptive effects of hypoxia. Methods and Design Insulin-producing…”
Get full text

Preconditioning with Associated Blocking of Ca.sup.2+ Inflow Alleviates Hypoxia-Induced Damage to Pancreatic [beta]-Cells by Ma, Zuheng, Moruzzi, Noah, Catrina, Sergiu-Bogdan, Hals, Ingrid, Oberholzer, José, Grill, Valdemar, Björklund, Anneli

“…Objective Beta cells of pancreatic islets are susceptible to functional deficits and damage by hypoxia. Here we aimed to characterize such effects and to test…”
Get full text