Search Results - "Halpin, Rita A"

Absorption, Metabolism, and Excretion of Etoricoxib, a Potent and Selective Cyclooxygenase-2 Inhibitor, in Healthy Male Volunteers by Rodrigues, A David, Halpin, Rita A, Geer, Leslie A, Cui, Donghui, Woolf, Eric J, Matthews, Catherine Z, Gottesdiener, Keith M, Larson, Patrick J, Lasseter, Kenneth C, Agrawal, Nancy G B

“…[ 14 C]Etoricoxib (100 μCi/dose) was administered to six healthy male subjects (i.v., 25 mg; p.o., 100 mg). Following the i.v. dose, the plasma clearance was…”
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Role of Human Liver Cytochrome P4503A in the Metabolism of Etoricoxib, a Novel Cyclooxygenase-2 Selective Inhibitor by KASSAHUN, Kelem, MCINTOSH, Ian S, SHOU, Magang, WALSH, Deborah J, RODEHEFFER, Carey, SLAUGHTER, Donald E, GEER, Leslie A, HALPIN, Rita A, AGRAWAL, Nancy, RODRIGUES, A. David

“…Etoricoxib, a potent and selective cyclooxygenase-2 inhibitor, was shown to be metabolized via 6′-methylhydroxylation (M2 formation) when incubated with…”
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The Disposition and Metabolism of Rofecoxib, a Potent and Selective Cyclooxygenase-2 Inhibitor, in Human Subjects by HALPIN, Rita A, PORRAS, Arturo G, SCHWARTZ, Jules I, LASSETER, Kenneth C, VYAS, Kamlesh P, BAILLIE, Thomas A, GEER, Leslie A, DAVIS, Margaret R, CUI, Donghui, DOSS, George A, WOOLF, Eric, MUSSON, Donald, MATTHEWS, Catherine, MAZENKO, Ralph

“…The disposition and metabolism of rofecoxib, a selective cyclooxygenase-2 inhibitor, were examined in healthy human subjects and in cholecystectomy patients…”
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METABOLISM OF ROFECOXIB IN VITRO USING HUMAN LIVER SUBCELLULAR FRACTIONS by SLAUGHTER, Donald, TAKENAGA, Norihiro, BAILLIE, Thomas A, PING LU, ASSANG, Carol, WALSH, Deborah J, ARISON, Byron H, DONGHUI CUI, HALPIN, Rita A, GEER, Leslie A, VYAS, Kamlesh P

“…The metabolism of rofecoxib, a potent and selective inhibitor of cyclooxygenase-2, was examined in vitro using human liver subcellular fractions. The…”
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Development of Orally Active Oxytocin Antagonists:  Studies on 1-(1-{4-[1-(2-Methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and Related Pyridines by Bell, Ian M, Erb, Jill M, Freidinger, Roger M, Gallicchio, Steven N, Guare, James P, Guidotti, Maribeth T, Halpin, Rita A, Hobbs, Doug W, Homnick, Carl F, Kuo, Michelle S, Lis, Edward V, Mathre, David J, Michelson, Stuart R, Pawluczyk, Joseph M, Pettibone, Douglas J, Reiss, Duane R, Vickers, Stanley, Williams, Peter D, Woyden, Carla J

“…The previously reported oxytocin antagonist L-371,257 (2) has been modified at its acetylpiperidine terminus to incorporate various pyridine N-oxide groups…”
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The Absorption, Distribution, Metabolism and Excretion of Rofecoxib, a Potent and Selective Cyclooxygenase-2 Inhibitor, in Rats and Dogs by HALPIN, Rita A, GEER, Leslie A, ZHANG, Kanyin E, MARKS, Tina M, DEAN, Dennis C, JONES, Allen N, MELILLO, David, DOSS, George, VYAS, Kamlesh P

“…Absorption, distribution, metabolism, and excretion studies were conducted in rats and dogs with rofecoxib (VIOXX, MK-0966), a potent and highly selective…”
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Mechanistic Studies on the Reversible Metabolism of Rofecoxib to 5-Hydroxyrofecoxib in the Rat: Evidence for Transient Ring Opening of a Substituted 2-Furanone Derivative Using Stable Isotope-Labeling Techniques by BAILLIE, Thomas A, HALPIN, Rita A, MELILLO, David, VYAS, Kamlesh P, MATUSZEWSKI, Bogdan K, GEER, Leslie A, CHAVEZ-ENG, Cynthia M, DEAN, Dennis, BRAUN, Matthew, DOSS, George, JONES, Allen, MARKS, Tina

“…Rofecoxib is a potent and highly selective cyclooxygenase-2 inhibitor used for the treatment of osteoarthritis and pain. Following administration of [4- 14…”
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Carbon-13 nuclear magnetic resonance studies of mandelate metabolism in whole bacterial cells and in isolated, in vivo cross-linked enzyme complexes by Halpin, Rita A, Hegeman, George D, Kenyon, George L

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Disposition and pharmacokinetics of the antimigraine drug, rizatriptan, in humans by VYAS, K. P, HALPIN, R. A, ROGERS, J. D, GEER, L. A, ELLIS, J. D, LIU, L, HAIYUNG CHENG, CHAVEZ-ENG, C, MATUSZEWSKI, B. K, VARGA, S. L, GUIBLIN, A. R

“…The absorption and disposition of rizatriptan (MK-0462, Maxalt(TM)), a selective 5-HT(1B/1D) receptor agonist used in the treatment of migraine headaches, was…”
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Sarcoplasmic reticulum. XVII. The turnover of proteins and phospholipids in sarcoplasmic reticulum membranes by Martonosi, A, Halpin, R A

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Metabolism and hepatotoxicity of the naturally occurring benzo[b]pyran precocene I by Halpin, R A, Vyas, K P, El-Naggar, S F, Jerina, D M

“…The in vitro metabolism of precocene I by liver microsomes from control and treated rats and the effects of precocene I on the function and histology of the…”
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