Search Results - "Halpert, Matthew M."

CD8 + CD161 + T-Cells: Cytotoxic Memory Cells With High Therapeutic Potential by Konduri, Vanaja, Oyewole-Said, Damilola, Vazquez-Perez, Jonathan, Weldon, Scott A, Halpert, Matthew M, Levitt, Jonathan M, Decker, William K

“…NK1.1 and its human homolog CD161 are expressed on NK cells, subsets of CD4 and CD8 T cells, and NKT cells. While the expression of NK1.1 is thought to be…”
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Evaluations for in vitro correlates of immunogenicity of inactivated influenza a H5, H7 and H9 vaccines in humans by Couch, Robert B, Decker, William K, Utama, Budi, Atmar, Robert L, Niño, Diane, Feng, Jing Qi, Halpert, Matthew M, Air, Gillian M

“…Serum antibody responses in humans to inactivated influenza A (H5N1), (H9N2) and A (H7) vaccines have been varied but frequently low, particularly for subunit…”
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AIMp1 Potentiates TH1 Polarization and Is Critical for Effective Antitumor and Antiviral Immunity by Liang, Dan, Tian, Lin, You, Ran, Halpert, Matthew M., Konduri, Vanaja, Baig, Yunyu C., Paust, Silke, Kim, Doyeun, Kim, Sunghoon, Jia, Fuli, Huang, Shixia, Zhang, Xiang, Kheradmand, Farrah, Corry, David B., Gilbert, Brian E., Levitt, Jonathan M., Decker, William K.

“…Dendritic cells (DCs) must integrate a broad array of environmental cues to exact control over downstream immune responses including T H polarization. The…”
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TLT2 potentiates neutrophil antibacterial activity and chemotaxis in response to G protein-coupled receptor-mediated signaling by Halpert, Matthew M, Thomas, Kimberly A, King, R Glenn, Justement, Louis B

“…Receptors encoded within the Trem locus have been shown to play an important role in modulating the cellular response to pattern recognition receptor…”
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A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain by Verrico, Chris D., Wesson, Shonda, Konduri, Vanaja, Hofferek, Colby J., Vazquez-Perez, Jonathan, Blair, Emek, Dunner, Kenneth, Salimpour, Pedram, Decker, William K., Halpert, Matthew M.

“…Over the last 2 decades, affirmative diagnoses of osteoarthritis (OA) in the United States have tripled due to increasing rates of obesity and an aging…”
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Generation of functional CLL-specific cord blood CTL using CD40-ligated CLL APC by Decker, William K, Shah, Nina, Xing, Dongxia, Lapushin, Ruth, Li, Sufang, Robinson, Simon N, Yang, Hong, Parmar, Simrit, Halpert, Matthew M, Keating, Michael J, Gribben, John G, Molldrem, Jeffrey J, Shpall, Elizabeth J, Wierda, William G

“…Though remissions have been observed following allo-HSCT for the treatment of CLL, many CLL patients are ineligible for transplant due to the lack of…”
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Multifactoral immune modulation potentiates durable remission in multiple models of aggressive malignancy by Halpert, Matthew M., Burns, Briana A., Rosario, Spencer R., Withers, Henry G., Trivedi, Akshar J., Hofferek, Colby J., Gephart, Benjamin D., Wang, Haotong, Vazquez‐Perez, Jonathan, Amanya, Sharon B., Hyslop, Sean T., Yang, Jianhua, Kemnade, Jan O., Sandulache, Vlad C., Konduri, Vanaja, Decker, William K.

“…Tumors typically lack canonical danger signals required to activate adaptive immunity and also frequently employ substantial immunomodulatory mechanisms that…”
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A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma by Konduri, Vanaja, Joseph, Sujith K, Byrd, Tiara T, Nawas, Zeid, Vazquez-Perez, Jonathan, Hofferek, Colby J, Halpert, Matthew M, Liu, Dongliang, Liang, Zhengdong, Baig, Yunyu, Salsman, Vita S, Oyewole-Said, Damilola, Tsimelzon, Anna, Burns, Briana A, Chen, Changyi, Levitt, Jonathan M, Yao, Qizhi, Ahmed, Nabil M, Hegde, Meenakshi, Decker, William K

“…In humans, the natural killer (NK) cell marker CD161 identifies several subsets of T cells, including a polyclonal CD8 αβ T cell receptor-expressing subset…”
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Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7 by Halpert, Matthew M, Konduri, Vanaja, Liang, Dan, Chen, Yunyu, Wing, James B, Paust, Silke, Levitt, Jonathan M, Decker, William K

“…The remarkable functional plasticity of professional antigen-presenting cells (APCs) allows the adaptive immune system to respond specifically to an incredibly…”
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MHC class I and II peptide homology regulates the cellular immune response by Halpert, Matthew M., Konduri, Vanaja, Liang, Dan, Vazquez‐Perez, Jonathan, Hofferek, Colby J., Weldon, Scott A., Baig, Yunyu, Vedula, Indira, Levitt, Jonathan M., Decker, William K.

“…Mammalian immune responses are initiated by “danger” signals––immutable molecular structures known as PAMPs. When detected by fixed, germline encoded…”
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Genetic Adjuvantation of a Cell-Based Therapeutic Vaccine for Amelioration of Chagasic Cardiomyopathy by Konduri, Vanaja, Halpert, Matthew M, Liang, Dan, Levitt, Jonathan M, Cruz-Chan, Julio Vladimir, Zhan, Bin, Bottazzi, Maria Elena, Hotez, Peter J, Jones, Kathryn M, Decker, William K

“…Chagas disease, caused by infection with the protozoan parasite , is a leading cause of heart disease ("chagasic cardiomyopathy") in Latin America,…”
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Modeling Dendritic Cell Vaccination for Influenza Prophylaxis: Potential Applications for Niche Populations by Konduri, Vanaja, Decker, William K., Halpert, Matthew M., Gilbert, Brian, Safdar, Amar

“…Background. Cancer patients can exhibit negligible responses to prophylactic vaccinations, including influenza vaccination. To help address this issue, we…”
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Chemo-immunotherapy mediates durable cure of orthotopic K ras G12D /p53 -/- pancreatic ductal adenocarcinoma by Konduri, Vanaja, Li, Dali, Halpert, Matthew M, Liang, Dan, Liang, Zhengdong, Chen, Yunyu, Fisher, William E, Paust, Silke, Levitt, Jonathan M, Yao, Qizhi Cathy, Decker, William K

“…Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related death in the United States, exhibiting a five-year overall survival (OS)…”
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Chemo-immunotherapy mediates durable cure of orthotopic KrasG12D/p53−/− pancreatic ductal adenocarcinoma by Konduri, Vanaja, Li, Dali, Halpert, Matthew M., Liang, Dan, Liang, Zhengdong, Chen, Yunyu, Fisher, William E., Paust, Silke, Levitt, Jonathan M., Yao, Qizhi Cathy, Decker, William K.

“…Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related death in the United States, exhibiting a five-year overall survival (OS)…”
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Low Dose Gemcitabine plus TH1 Dendritic Cell Vaccination Mediates Durable Cure of Orthotopic KrasG12D/p53−/− Pancreatic Ductal Adenocarcinoma via the Generation of Atypical CD3+CD8+NK1.1+ T-cells by Konduri, Vanaja, Li, Dali, Halpert, Matthew M., Liang, Dan, Liang, Zhengdong, Chen, Yunyu, Fisher, William E, Levitt, Jonathan M, Yao, Qizhi Cathy, Decker, William K

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer related death in the United States with a five-year overall survival of…”
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Abstract LB-201: Durable remission of lethal canine hemangiosarcoma by Halpert, Matthew M., Konduri, Vanaja, Chen, Yunyu, Liang, Dan, Levitt, Jonathan M., Neal, Brittany, Hudson, Caleb, Hottinger, Heidi, Piscoya, Sindy, Wilson, Nicola, DiBernardi, Lisa, Stallings, Shonda, Omarbekov, Zharkyn, Seelhof, Lori, Ramirez, Oscar, Yao, Qizhi C., Bhardwaj, Ratan D., Ravi, Vinod, Douglass, Laurel, Decker, William K.

“…Abstract Background: Angiosarcoma is an uncommon but deadly malignant neoplasm of the vascular endothelium. Primary disease may present at any vascularized…”
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Active specific immunotherapy for lethal canine hemangiosarcoma: A model system for the treatment of angiosarcoma with curative intent by Decker, William Karl, Douglass, Laurel, Halpert, Matthew M, Konduri, Vanaja, Chen, Yunyu, Liang, Dan, Levitt, Jonathan M, Neal, Brittany, Hudson, Caleb, Hottinger, Heidi, Piscoya, Sindy, Wilson, Nicola, DiBernardi, Lisa, Stallings, Shonda, Omarbekov, Zharkyn, Seelhoff, Lori, Ramirez, Oscar, Yao, Qizhi Cathy, Bhardwaj, Ratan D, Ravi, Vinod

“…Abstract only e14539 Background: Angiosarcoma is a deadly malignant neoplasm of the vascular endothelium. Metastases are often present at diagnosis, and 5-year…”
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Active Specific Immunotherapy plus Doxorubicin Chemotherapy Mediates Durable Remission of Lethal Canine Hemangiosarcoma by Konduri, Vanaja, Halpert, Matthew M, Chen, Yunyu, Liang, Dan, Levitt, Jonathan M, Neal, Brittany, Husdon, Caleb, Hottinger, Heidi, Piscoya, Sindy, Wilson, Nicola, DiBernardi, Lisa, Stallings, Shonda, Omarbekov, Zarkhyn, Seelhoff, Lori, Ramirez, Oscar, Yao, Qizhi C, Bhardwaj, Ratan D, Ravi, Vinod, Douglass, Laurel, Decker, William K

“…Abstract Angiosarcoma is a deadly neoplasm of the vascular endothelium. Metastases are often present at diagnosis, and 5-year survival is only 10–30%. While…”
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Abstract LB-132: The potential role of the multienzyme aminoacyl-tRNA synthetase complex in Th-1 immunity: implications for cancer immunotherapy by Halpert, Matthew M., Spencer, David, Bhardwaj, Ratan, Berens, Michael E., Decker, William K.

“…Abstract Recent advances in dendritic cell (DC)-based cancer vaccines have highlighted the potential utility of arming the immune system to target neoplastic…”
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AIMp1 Potentiates T H 1 Polarization and Is Critical for Effective Antitumor and Antiviral Immunity by Liang, Dan, Tian, Lin, You, Ran, Halpert, Matthew M, Konduri, Vanaja, Baig, Yunyu C, Paust, Silke, Kim, Doyeun, Kim, Sunghoon, Jia, Fuli, Huang, Shixia, Zhang, Xiang, Kheradmand, Farrah, Corry, David B, Gilbert, Brian E, Levitt, Jonathan M, Decker, William K

“…Dendritic cells (DCs) must integrate a broad array of environmental cues to exact control over downstream immune responses including T polarization. The…”
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