Search Results - "Halpern, Keren Bahar"

Nuclear Retention of mRNA in Mammalian Tissues by Bahar Halpern, Keren, Caspi, Inbal, Lemze, Doron, Levy, Maayan, Landen, Shanie, Elinav, Eran, Ulitsky, Igor, Itzkovitz, Shalev

“…mRNA is thought to predominantly reside in the cytoplasm, where it is translated and eventually degraded. Although nuclear retention of mRNA has a regulatory…”
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Spatial Reconstruction of Single Enterocytes Uncovers Broad Zonation along the Intestinal Villus Axis by Moor, Andreas E., Harnik, Yotam, Ben-Moshe, Shani, Massasa, Efi E., Rozenberg, Milena, Eilam, Raya, Bahar Halpern, Keren, Itzkovitz, Shalev

“…The intestinal epithelium is a highly structured tissue composed of repeating crypt-villus units. Enterocytes perform the diverse tasks of absorbing a wide…”
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Clump sequencing exposes the spatial expression programs of intestinal secretory cells by Manco, Rita, Averbukh, Inna, Porat, Ziv, Bahar Halpern, Keren, Amit, Ido, Itzkovitz, Shalev

“…Single-cell RNA sequencing combined with spatial information on landmark genes enables reconstruction of spatially-resolved tissue cell atlases. However, such…”
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The spatiotemporal program of zonal liver regeneration following acute injury by Ben-Moshe, Shani, Veg, Tamar, Manco, Rita, Dan, Stav, Papinutti, Delfina, Lifshitz, Aviezer, Kolodziejczyk, Aleksandra A, Bahar Halpern, Keren, Elinav, Eran, Itzkovitz, Shalev

“…The liver carries a remarkable ability to regenerate rapidly after acute zonal damage. Single-cell approaches are necessary to study this process, given the…”
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Microglia development follows a stepwise program to regulate brain homeostasis by Matcovitch-Natan, Orit, Winter, Deborah R., Guadi, Amir, Aguilar, Stephanie Vargas, Spinrad, Amit, Sarrazin, Sandrine, Ben-Yehuda, Hila, David, Eyal, González, Fabiola Zelada, Perrin, Pierre, Keren-Shaul, Hadas, Gury, Meital, Lara-Astaiso, David, Thaiss, Christoph A., Cohen, Merav, Halpern, Keren Bahar, Baruch, Kuti, Deczkowska, Aleksandra, Lorenzo-Vivas, Erika, Itzkovitz, Shalev, Elinav, Eran, Sieweke, Michael H., Schwartz, Michal, Amit, Ido

“…Microglia, the resident myeloid cells of the central nervous system, play important roles in life-long brain maintenance and in pathology. Despite their…”
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A single cell atlas of the human liver tumor microenvironment by Massalha, Hassan, Bahar Halpern, Keren, Abu‐Gazala, Samir, Jana, Tamar, Massasa, Efi E, Moor, Andreas E, Buchauer, Lisa, Rozenberg, Milena, Pikarsky, Eli, Amit, Ido, Zamir, Gideon, Itzkovitz, Shalev

“…Malignant cell growth is fueled by interactions between tumor cells and the stromal cells composing the tumor microenvironment. The human liver is a major site…”
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Paradoxical Role of DNA Methylation in Activation of FoxA2 Gene Expression during Endoderm Development by Bahar Halpern, Keren, Vana, Tal, Walker, Michael D.

“…The transcription factor FoxA2 is a master regulator of endoderm development and pancreatic beta cell gene expression. To elucidate the mechanisms underlying…”
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Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas by Farack, Lydia, Golan, Matan, Egozi, Adi, Dezorella, Nili, Bahar Halpern, Keren, Ben-Moshe, Shani, Garzilli, Immacolata, Tóth, Beáta, Roitman, Lior, Krizhanovsky, Valery, Itzkovitz, Shalev

“…Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However, spatially interrogating transcriptional heterogeneity in the intact…”
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Lgr5+ telocytes are a signaling source at the intestinal villus tip by Bahar Halpern, Keren, Massalha, Hassan, Zwick, Rachel K., Moor, Andreas E., Castillo-Azofeifa, David, Rozenberg, Milena, Farack, Lydia, Egozi, Adi, Miller, Dan R., Averbukh, Inna, Harnik, Yotam, Weinberg-Corem, Noa, de Sauvage, Frederic J., Amit, Ido, Klein, Ophir D., Shoshkes-Carmel, Michal, Itzkovitz, Shalev

“…The intestinal epithelium is a structured organ composed of crypts harboring Lgr5+ stem cells, and villi harboring differentiated cells. Spatial…”
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Spatial sorting enables comprehensive characterization of liver zonation by Ben-Moshe, Shani, Shapira, Yonatan, Moor, Andreas E., Manco, Rita, Veg, Tamar, Bahar Halpern, Keren, Itzkovitz, Shalev

“…The mammalian liver is composed of repeating hexagonal units termed lobules. Spatially resolved single-cell transcriptomics has revealed that about half of…”
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Spatial gene expression maps of the intestinal lymphoid follicle and associated epithelium identify zonated expression programs by Cohen, Noam, Massalha, Hassan, Ben-Moshe, Shani, Egozi, Adi, Rozenberg, Milena, Bahar Halpern, Keren, Itzkovitz, Shalev

“…The intestine is lined with isolated lymphoid follicles (ILFs) that facilitate sampling of luminal antigens to elicit immune responses. Technical challenges…”
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Insulin is expressed by enteroendocrine cells during human fetal development by Egozi, Adi, Llivichuzhca-Loja, Dhana, McCourt, Blake T., Bahar Halpern, Keren, Farack, Lydia, An, Xiaojing, Wang, Fujing, Chen, Kong, Konnikova, Liza, Itzkovitz, Shalev

“…Generation of beta cells via transdifferentiation of other cell types is a promising avenue for the treatment of diabetes. Here we reconstruct a single-cell…”
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Bursty Gene Expression in the Intact Mammalian Liver by Bahar Halpern, Keren, Tanami, Sivan, Landen, Shanie, Chapal, Michal, Szlak, Liran, Hutzler, Anat, Nizhberg, Anna, Itzkovitz, Shalev

“…Bursts of nascent mRNA have been shown to lead to substantial cell-cell variation in unicellular organisms, facilitating diverse responses to environmental…”
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Single molecule approaches for quantifying transcription and degradation rates in intact mammalian tissues by Bahar Halpern, Keren, Itzkovitz, Shalev

“…•Single molecule approach for quantifying transcription and mRNA degradation rates.•Based on detection of mature and nascent mRNA with intronic and exonic…”
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Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting by Cohen, Merav, Giladi, Amir, Gorki, Anna-Dorothea, Solodkin, Dikla Gelbard, Zada, Mor, Hladik, Anastasiya, Miklosi, Andras, Salame, Tomer-Meir, Halpern, Keren Bahar, David, Eyal, Itzkovitz, Shalev, Harkany, Tibor, Knapp, Sylvia, Amit, Ido

“…Lung development and function arises from the interactions between diverse cell types and lineages. Using single-cell RNA sequencing (RNA-seq), we characterize…”
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Dynamic zonation of liver polyploidy by Tanami, Sivan, Ben-Moshe, Shani, Elkayam, Anat, Mayo, Avi, Bahar Halpern, Keren, Itzkovitz, Shalev

“…The liver is a polyploid organ, consisting of hepatocytes with one or two nuclei each containing 2, 4, 8 or more haploid chromosome sets. The dynamic changes…”
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A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage by Afriat, Amichay, Zuzarte-Luís, Vanessa, Bahar Halpern, Keren, Buchauer, Lisa, Marques, Sofia, Chora, Ângelo Ferreira, Lahree, Aparajita, Amit, Ido, Mota, Maria M., Itzkovitz, Shalev

“…Malaria infection involves an obligatory, yet clinically silent liver stage 1 , 2 . Hepatocytes operate in repeating units termed lobules, exhibiting…”
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Zonation of Pancreatic Acinar Cells in Diabetic Mice by Egozi, Adi, Bahar Halpern, Keren, Farack, Lydia, Rotem, Hagar, Itzkovitz, Shalev

“…The islets of Langerhans are dynamic structures that can change in size, number of cells, and molecular function in response to physiological and pathological…”
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Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma by Ledergor, Guy, Weiner, Assaf, Zada, Mor, Wang, Shuang-Yin, Cohen, Yael C., Gatt, Moshe E., Snir, Nimrod, Magen, Hila, Koren-Michowitz, Maya, Herzog-Tzarfati, Katrin, Keren-Shaul, Hadas, Bornstein, Chamutal, Rotkopf, Ron, Yofe, Ido, David, Eyal, Yellapantula, Venkata, Kay, Sigalit, Salai, Moshe, Ben Yehuda, Dina, Nagler, Arnon, Shvidel, Lev, Orr-Urtreger, Avi, Halpern, Keren Bahar, Itzkovitz, Shalev, Landgren, Ola, San-Miguel, Jesus, Paiva, Bruno, Keats, Jonathan J., Papaemmanuil, Elli, Avivi, Irit, Barbash, Gabriel I., Tanay, Amos, Amit, Ido

“…Multiple myeloma, a plasma cell malignancy, is the second most common blood cancer. Despite extensive research, disease heterogeneity is poorly characterized,…”
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Space-time logic of liver gene expression at sub-lobular scale by Droin, Colas, Kholtei, Jakob El, Bahar Halpern, Keren, Hurni, Clémence, Rozenberg, Milena, Muvkadi, Sapir, Itzkovitz, Shalev, Naef, Felix

“…The mammalian liver is a central hub for systemic metabolic homeostasis. Liver tissue is spatially structured, with hepatocytes operating in repeating lobules,…”
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