Search Results - "Halmen, Kristen A."

Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9 by Parroche, Peggy, Lauw, Fanny N, Goutagny, Nadege, Latz, Eicke, Monks, Brian G, Visintin, Alberto, Halmen, Kristen A, Lamphier, Marc, Olivier, Martin, Bartholomeu, Daniella C, Gazzinelli, Ricardo T, Golenbock, Douglas T

“…Hemozoin (HZ) is an insoluble crystal formed in the food vacuole of malaria parasites. HZ has been reported to induce inflammation by directly engaging…”
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Pharmacological Inhibition of Endotoxin Responses Is Achieved by Targeting the TLR4 Coreceptor, MD-2 by Visintin, Alberto, Halmen, Kristen A, Latz, Eicke, Monks, Brian G, Golenbock, Douglas T

“…The detection of Gram-negative LPS depends upon the proper function of the TLR4-MD-2 receptor complex in immune cells. TLR4 is the signal transduction…”
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Meningococcal Porin PorB Binds to TLR2 and Requires TLR1 for Signaling by Massari, Paola, Visintin, Alberto, Gunawardana, Jay, Halmen, Kristen A, King, Carol A, Golenbock, Douglas T, Wetzler, Lee M

“…TLR2 plays a key role in the initiation of the cellular innate immune responses by a wide range of bacterial products. TLRs signaling, including TLR2 and its…”
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Phagocytosis and intracellular killing of MD-2 opsonized Gram-negative bacteria depend on TLR4 signaling by Jain, Vishal, Halle, Annett, Halmen, Kristen A., Lien, Egil, Charrel-Dennis, Marie, Ram, Sanjay, Golenbock, Douglas T., Visintin, Alberto

“…Both Toll-like receptor 4 (TLR4)– and MD-2–deficient mice succumb to otherwise nonfatal Gram-negative bacteria inocula, demonstrating the pivotal role played…”
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MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4) by Visintin, Alberto, Halmen, Kristen A., Khan, Naseema, Monks, Brian G., Golenbock, Douglas T., Lien, Egil

“…The cell surface receptor complex formed by TLR4 and myeloid differentiation 2 (MD‐2) is engaged when cells are exposed to LPS. Recent studies suggested that…”
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TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA by Charrel-Dennis, Marie, Latz, Eicke, Halmen, Kristen A, Trieu-Cuot, Patrick, Fitzgerald, Katherine A, Kasper, Dennis L, Golenbock, Douglas T

“…Type I interferon (IFN) is an important host defense cytokine against intracellular pathogens, mainly viruses. In assessing IFN production in response to group…”
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MD-2 by Visintin, Alberto, Iliev, Dimitar B., Monks, Brian G., Halmen, Kristen A., Golenbock, Douglas T.

“…Toll-like receptors (TLRs) are a small family of type-I glycoproteins that bind to and are activated by conserved non-self molecular signatures carried by…”
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