Search Results - "Halloran, P. F."

Understanding the Causes of Kidney Transplant Failure: The Dominant Role of Antibody‐Mediated Rejection and Nonadherence by Sellarés, J., de Freitas, D. G., Mengel, M., Reeve, J., Einecke, G., Sis, B., Hidalgo, L. G., Famulski, K., Matas, A., Halloran, P. F.

“…We prospectively studied kidney transplants that progressed to failure after a biopsy for clinical indications, aiming to assign a cause to every failure. We…”
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NK Cell Transcripts and NK Cells in Kidney Biopsies from Patients with Donor‐Specific Antibodies: Evidence for NK Cell Involvement in Antibody‐Mediated Rejection by Hidalgo, L. G., Sis, B., Sellares, J., Campbell, P. M., Mengel, M., Einecke, G., Chang, J., Halloran, P. F.

“…To explore the mechanisms of antibody‐mediated rejection (ABMR) in kidney transplants, we studied the transcripts expressed in clinically indicated biopsies…”
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Molecular Diagnosis of Antibody‐Mediated Rejection in Human Kidney Transplants by Sellarés, J., Reeve, J., Loupy, A., Mengel, M., Sis, B., Skene, A., de Freitas, D. G., Kreepala, C., Hidalgo, L. G., Famulski, K. S., Halloran, P. F.

“…Antibody‐mediated rejection is the major cause of kidney transplant failure, but the histology‐based diagnostic system misses most cases due to its requirement…”
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Molecular Diagnosis of T Cell‐Mediated Rejection in Human Kidney Transplant Biopsies by Reeve, J., Sellarés, J., Mengel, M., Sis, B., Skene, A., Hidalgo, L., de Freitas, D. G., Famulski, K. S., Halloran, P. F.

“…Histologic diagnosis of T cell‐mediated rejection is flawed by subjective assessments, nonspecific lesions and arbitrary rules. This study developed a…”
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Banff 2011 Meeting Report: New Concepts in Antibody‐Mediated Rejection by Mengel, M., Sis, B., Haas, M., Colvin, R. B., Halloran, P. F., Racusen, L. C., Solez, K., Cendales, L., Demetris, A. J., Drachenberg, C. B., Farver, C. F., Rodriguez, E. R., Wallace, W. D., Glotz, D.

“…The 11th Banff meeting was held in Paris, France, from June 5 to 10, 2011, with a focus on refining diagnostic criteria for antibody‐mediated rejection (ABMR)…”
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De Novo Donor‐Specific Antibody at the Time of Kidney Transplant Biopsy Associates with Microvascular Pathology and Late Graft Failure by Hidalgo, L. G., Campbell, P. M., Sis, B., Einecke, G., Mengel, M., Chang, J., Sellares, J., Reeve, J., Halloran, P. F.

“…We studied whether de novo donor‐specific antibodies (DSA) in sera from patients undergoing kidney transplant biopsies associate with specific histologic…”
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Molecular Landscape of T Cell–Mediated Rejection in Human Kidney Transplants: Prominence of CTLA4 and PD Ligands by Venner, J. M., Famulski, K. S., Badr, D., Hidalgo, L. G., Chang, J., Halloran, P. F.

“…We used expression microarrays to characterize the changes most specific for pure T cell–mediated rejection (TCMR) compared to other diseases including…”
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T Cell‐mediated Rejection of Kidney Transplants: A Personal Viewpoint by Halloran, P. F.

“…In kidney allografts, T cell mediated rejection (TCMR) is characterized by infiltration of the interstitium by T cells and macrophages, intense IFNG and TGFB…”
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Interpreting NK Cell Transcripts Versus T Cell Transcripts in Renal Transplant Biopsies by Hidalgo, L. G., Sellares, J., Sis, B., Mengel, M., Chang, J., Halloran, P. F.

“…NK cell transcripts are increased in biopsies with antibody‐mediated rejection, whereas T cell transcripts are increased in T cell‐mediated rejection. However,…”
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Microarray Diagnosis of Antibody‐Mediated Rejection in Kidney Transplant Biopsies: An International Prospective Study (INTERCOM) by Halloran, P. F., Pereira, A. B., Chang, J., Matas, A., Picton, M., De Freitas, D., Bromberg, J., Serón, D., Sellarés, J., Einecke, G., Reeve, J.

“…In a reference set of 403 kidney transplant biopsies, we recently developed a microarray‐based test that diagnoses antibody‐mediated rejection (ABMR) by…”
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A New Diagnostic Algorithm for Antibody‐Mediated Microcirculation Inflammation in Kidney Transplants by Sis, B., Jhangri, G. S., Riopel, J., Chang, J., de Freitas, D. G., Hidalgo, L., Mengel, M., Matas, A., Halloran, P. F.

“…We studied the significance of microcirculation inflammation in kidney transplants, including 329 indication biopsies from 251 renal allograft recipients, who…”
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The Role of Donor‐Specific HLA Alloantibodies in Liver Transplantation by O'Leary, J. G., Demetris, A. J., Friedman, L. S., Gebel, H. M., Halloran, P. F., Kirk, A. D., Knechtle, S. J., McDiarmid, S. V., Shaked, A., Terasaki, P. I., Tinckam, K. J., Tomlanovich, S. J., Wood, K. J., Woodle, E. S., Zachary, A. A., Klintmalm, G. B.

“…The impact of donor‐specific HLA alloantibodies (DSA) on short‐ and long‐term liver transplant outcome is not clearly defined. While it is clear that not all…”
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Potential Impact of Microarray Diagnosis of T Cell–Mediated Rejection in Kidney Transplants: The INTERCOM Study by Halloran, P. F., Pereira, A. B., Chang, J., Matas, A., Picton, M., De Freitas, D., Bromberg, J., Serón, D., Sellarés, J., Einecke, G., Reeve, J.

“…We previously developed a microarray‐based test for T cell‐mediated rejection (TCMR) in a reference set of 403 biopsies. To determine the potential impact of…”
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Diagnosing Rejection in Renal Transplants: A Comparison of Molecular‐ and Histopathology‐Based Approaches by Reeve, J., Einecke, G., Mengel, M., Sis, B., Kayser, N., Kaplan, B., Halloran, P. F.

“…The transcriptome has considerable potential for improving biopsy diagnoses. However, to realize this potential the relationship between the molecular…”
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Antibody‐Mediated Microcirculation Injury Is the Major Cause of Late Kidney Transplant Failure by Einecke, G., Sis, B., Reeve, J., Mengel, M., Campbell, P. M., Hidalgo, L. G., Kaplan, B., Halloran, P. F.

“…We studied the phenotype of late kidney graft failure in a prospective study of unselected kidney transplant biopsies taken for clinical indications. We…”
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Inflammation in Areas of Tubular Atrophy in Kidney Allograft Biopsies: A Potent Predictor of Allograft Failure by Mannon, R. B., Matas, A. J., Grande, J., Leduc, R., Connett, J., Kasiske, B., Cecka, J. M., Gaston, R. S., Cosio, F., Gourishankar, S., Halloran, P. F., Hunsicker, L., Rush, D.

“…The Banff scoring schema provides a common ground to analyze kidney transplant biopsies. Interstitial inflammation (i) and tubulitis (t) in areas of viable…”
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SWOT Analysis of Banff: Strengths, Weaknesses, Opportunities and Threats of the International Banff Consensus Process and Classification System for Renal Allograft Pathology by Mengel, M., Sis, B., Halloran, P. F.

“…The Banff process defined the diagnostic histologic lesions for renal allograft rejection and created a standardized classification system where none had…”
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Treatment Responses in Histologic Versus Molecular Diagnoses of Lung Rejection by Zajacova, A, Mackova, M, Halloran, K, Gauthier, P, Balko, J, Guney, M, Rakita, D, Svorcova, M, Kolarik, J, Vachtenheim, Jr, J, Pozniak, J, Simonek, J, Fila, L, Lischke, R, Halloran, P F, Havlin, J

“…Histologic evaluation of allograft biopsies after lung transplantation has several limitations, suggesting that molecular assessment using tissue…”
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Transplant Glomerulopathy, Late Antibody‐Mediated Rejection and the ABCD Tetrad in Kidney Allograft Biopsies for Cause by Sis, B., Campbell, P. M., Mueller, T., Hunter, C., Cockfield, S. M., Cruz, J., Meng, C., Wishart, D., Solez, K., Halloran, P. F.

“…To define the relative frequency of phenotypes of transplant glomerulopathy, we retrospectively reviewed the findings in 1036 biopsies for clinical indications…”
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The Nature of Biopsies with “Borderline Rejection” and Prospects for Eliminating This Category by de Freitas, D. G., Sellarés, J., Mengel, M., Chang, J., Hidalgo, L. G., Famulski, K. S., Sis, B., Einecke, G., Halloran, P. F.

“…In kidney transplantation, many inflamed biopsies with changes insufficient to be called T‐cell‐mediated rejection (TCMR) are labeled “borderline”, leaving…”
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