Search Results - "Halloran, B"

Clinical, endoscopic and radiographic outcomes with ustekinumab in medically‐refractory Crohn's disease: real world experience from a multicentre cohort by Ma, C., Fedorak, R. N., Kaplan, G. G., Dieleman, L. A., Devlin, S. M., Stern, N., Kroeker, K. I., Seow, C. H., Leung, Y., Novak, K. L., Halloran, B. P., Huang, V. W., Wong, K., Blustein, P. K., Ghosh, S., Panaccione, R.

“…Summary Background Ustekinumab is a monoclonal antibody targeting interleukins‐12 and ‐23, with efficacy in Crohn's disease (CD) demonstrated in clinical…”
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BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth by Wang, Tao, Xiao, Min, Ge, Yingbin, Krepler, Clemens, Belser, Eric, Lopez-Coral, Alfonso, Xu, Xiaowei, Zhang, Gao, Azuma, Rikka, Liu, Qin, Liu, Rui, Li, Ling, Amaravadi, Ravi K, Xu, Wei, Karakousis, Giorgos, Gangadhar, Tara C, Schuchter, Lynn M, Lieu, Melissa, Khare, Sanika, Halloran, Molly B, Herlyn, Meenhard, Kaufman, Russel E

“…To investigate the roles of melanoma-associated macrophages in melanoma resistance to BRAF inhibitors (BRAFi). An in vitro macrophage and melanoma cell…”
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Adalimumab dose escalation is effective for managing secondary loss of response in Crohn's disease by Ma, C., Huang, V., Fedorak, D. K., Kroeker, K. I., Dieleman, L. A., Halloran, B. P., Fedorak, R. N.

“…Summary Background The efficacy of adalimumab in maintaining remission in Crohn's disease patients may wane over time, leading to secondary loss of response…”
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Dried plum diet protects from bone loss caused by ionizing radiation by Schreurs, A.-S., Shirazi-Fard, Y., Shahnazari, M., Alwood, J. S., Truong, T. A., Tahimic, C. G. T., Limoli, C. L., Turner, N. D., Halloran, B., Globus, R. K.

“…Bone loss caused by ionizing radiation is a potential health concern for radiotherapy patients, radiation workers and astronauts. In animal studies, exposure…”
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PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas by Lee, John T., Li, Ling, Brafford, Patricia A., van den Eijnden, Marcia, Halloran, Molly B., Sproesser, Katrin, Haass, Nikolas K., Smalley, Keiran S.M., Tsai, James, Bollag, Gideon, Herlyn, Meenhard

“…Summary Targeted intervention of the B‐Raf V600E gene product that is prominent in melanoma has been met with modest success. Here, we characterize the…”
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Effects of Dried Plum Supplementation on Bone Metabolism in Adult C57BL/6 Male Mice by Smith, B. J., Graef, J. L., Wronski, T. J., Rendina, E, Williams, A. A., Clark, K. A., Clarke, S. L., Lucas, E. A., Halloran, B. P.

“…Dietary supplementation of dried plum (DP) prevents bone loss and restores bone mass in osteopenic animal models. This study was designed to determine the…”
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Conditional Expression of a Gi-Coupled Receptor in Osteoblasts Results in Trabecular Osteopenia by Peng, J, Bencsik, M, Louie, A, Lu, W, Millard, S, Nguyen, P, Burghardt, A, Majumdar, S, Wronski, T. J, Halloran, B, Conklin, B. R, Nissenson, R. A

“…G protein-coupled receptors (GPCRs) coupled to activation of Gs, such as the PTH1 receptor (PTH1R), have long been known to regulate skeletal function and…”
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A longitudinal study of calcium homeostasis during human pregnancy and lactation and after resumption of menses by Ritchie, LD, Fung, EB, Halloran, BP, Turnlund, JR, Van Loan, MD, Cann, CE, King, JC

“…To clarify the role of the intestine, kidney, and bone in maintaining calcium homeostasis during pregnancy and lactation and after the resumption of menses, a…”
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Effects of spatial scale on assessment of dissolved oxygen dynamics in the Atchafalaya River Basin, Louisiana by Kaller, M. D, Kelso, W. E, Halloran, B. T, Rutherford, D. A

“…Low levels of dissolved oxygen (DO) are potential stressors of fishes and invertebrates in freshwater and marine systems. Because of the incredibly…”
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The skeletal structure of insulin-like growth factor I-deficient mice by Bikle, D., Majumdar, S., Laib, A., Powell-Braxton, L., Rosen, C., Beamer, W., Nauman, E., Leary, C., Halloran, B.

“…The importance of insulin-like growth factor I (IGF-I) for growth is well established. However, the lack of IGF-I on the skeleton has not been examined…”
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Skeletal unloading induces resistance to insulin-like growth factor I on bone formation by Sakata, T, Halloran, B.P, Elalieh, H.Z, Munson, S.J, Rudner, L, Venton, L, Ginzinger, D, Rosen, C.J, Bikle, D.D

“…Skeletal unloading results in an inhibition of bone formation associated with a decrease in osteoblast number, impaired mineralization of bone, and altered…”
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Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro by Wang, Liping, Zhao, Rong, Shi, Xiaoyou, Wei, Tzuping, Halloran, Bernard P, Clark, David J, Jacobs, Christopher R, Kingery, Wade S

“…Abstract Introduction SP is a neuropeptide distributed in the sensory nerve fibers that innervate the medullar tissues of bone, as well as the periosteum…”
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Osteoblasts respond to pulsatile fluid flow with short-term increases in PGE2 but no change in mineralization by Nauman, E. A, Satcher, R. L, Keaveny, T. M, Halloran, B. P, Bikle, D. D

“…1  Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, Berkeley 94720-1740; 2  Veterans Affairs Medical…”
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The response of bone to unloading by Bikle, D. D., Halloran, B. P.

“…Skeletal unloading leads to decreased bone formation and decreased bone mass. Bone resorption is uncoupled from bone formation, contributing to the bone loss…”
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PTH Differentially Regulates Expression of RANKL and OPG by Huang, John C, Sakata, Takeshi, Pfleger, Laura L, Bencsik, Margaret, Halloran, Bernard P, Bikle, Daniel D, Nissenson, Robert A

“…RANKL and OPG gene expressions were measured with and without PTH at different stages of osteoblast development. Mouse stromal cells were cultured in…”
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Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I by Kostenuik, P. J., Harris, J., Halloran, B. P., Turner, R. T., Morey-Holton, E. R., Bikle, D. D.

“…Skeletal unloading decreases bone formation and osteoblast number in vivo and decreases the number and proliferation of bone marrow osteoprogenitor (BMOp)…”
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Aging Increases Stromal/Osteoblastic Cell‐Induced Osteoclastogenesis and Alters the Osteoclast Precursor Pool in the Mouse by Cao, Jay J, Wronski, Thomas J, Iwaniec, Urszula, Phleger, Laura, Kurimoto, Pam, Boudignon, Benjamin, Halloran, Bernard P

“…Stromal/osteoblastic cell expression of RANKL and M‐CSF regulates osteoclastogenesis. We show that aging is accompanied by increased RANKL and M‐CSF…”
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Changes in Bone Structure and Mass With Advancing Age in the Male C57BL/6J Mouse by Halloran, Bernard P., Ferguson, Virginia L., Simske, Steven J., Burghardt, Andrew, Venton, Laura L., Majumdar, Sharmila

“…To determine whether the mouse loses bone with aging and whether the changes mimic those observed in human aging, we examined the changes in the tibial…”
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Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone by Bikle, Daniel D., Sakata, Takeshi, Leary, Colin, Elalieh, Hashem, Ginzinger, David, Rosen, Clifford J., Beamer, Wesley, Majumdar, Sharmila, Halloran, Bernard P.

“…Parathyroid hormone (PTH) is a potent anabolic agent for bone, but the mechanism(s) by which it works remains imperfectly understood. Previous studies have…”
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Bone and hormonal changes induced by skeletal unloading in the mature male rat by Dehority, W., Halloran, B. P., Bikle, D. D., Curren, T., Kostenuik, P. J., Wronski, T. J., Shen, Y., Rabkin, B., Bouraoui, A., Morey-Holton, E.

“…To determine whether the rat hindlimb elevation model can be used to study the effects of spaceflight and loss of gravitational loading on bone in the adult…”
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