Search Results - "Hallis, Tina M."

Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening by Shukla, Sunita J, Nguyen, Dac-Trung, Macarthur, Ryan, Simeonov, Anton, Frazee, William J, Hallis, Tina M, Marks, Bryan D, Singh, Upinder, Eliason, Hildegard C, Printen, John, Austin, Christopher P, Inglese, James, Auld, Douglas S

“…The human pregnane X nuclear receptor (PXR) is a xenobiotic-regulated receptor that is activated by a range of diverse chemicals, including antibiotics,…”
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Covalent Peroxisome Proliferator-activated Receptor γ Adduction by Nitro-fatty Acids: SELECTIVE LIGAND ACTIVITY AND ANTI-DIABETIC SIGNALING ACTIONS by Schopfer, Francisco J, Cole, Marsha P, Groeger, Alison L, Chen, Chen-Shan, Khoo, Nicholas K.H, Woodcock, Steven R, Golin-Bisello, Franca, Motanya, U. Nkiru, Li, Yong, Zhang, Jifeng, Garcia-Barrio, Minerva T, Rudolph, Tanja K, Rudolph, Volker, Bonacci, Gustavo, Baker, Paul R.S, Xu, H. Eric, Batthyany, Carlos I, Chen, Y. Eugene, Hallis, Tina M, Freeman, Bruce A

“…The peroxisome proliferator-activated receptor-γ (PPARγ) binds diverse ligands to transcriptionally regulate metabolism and inflammation. Activators of PPARγ…”
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The Biosynthesis of GDP-l-Colitose:  C-3 Deoxygenation Is Catalyzed by a Unique Coenzyme B6-Dependent Enzyme by Beyer, Noelle, Alam, Jenefer, Hallis, Tina M, Guo, Zhihong, Liu, Hung-wen

“…l-Colitose (1) is a 3,6-dideoxyhexose found in the O-antigen of gram-negative lipopoly-saccharides. While the biosynthesis of many deoxysugars have previously…”
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Simultaneous Monitoring of Discrete Binding Events Using Dual-Acceptor Terbium-Based LRET by Kupcho, Kevin R, Stafslien, Deborah K, DeRosier, Therese, Hallis, Tina M, Ozers, Mary Szatkowski, Vogel, Kurt W

“…Lanthanide resonance energy transfer (LRET) between chelated terbium and two spectrally distinct acceptor fluorophores (fluorescein and Alexa Fluor 633) is…”
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Characterization of a novel non-steroidal glucocorticoid receptor antagonist by Li, Qun-Yi, Zhang, Meng, Hallis, Tina M., DeRosier, Therese A., Yue, Jian-Min, Ye, Yang, Mais, Dale E., Wang, Ming-Wei

“…Selective antagonists of the glucocorticoid receptor (GR) are desirable for the treatment of hypercortisolemia associated with Cushing’s syndrome, psychic…”
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Learning Nature's Strategies for Making Deoxy Sugars:  Pathways, Mechanisms, and Combinatorial Applications by Hallis, Tina M, Liu, Hung-wen

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An improved beta-lactamase reporter assay: multiplexing with a cytotoxicity readout for enhanced accuracy of hit identification by Hallis, Tina M, Kopp, Andrew L, Gibson, Jasmin, Lebakken, Connie S, Hancock, Michael, Van Den Heuvel-Kramer, Kaitlyn, Turek-Etienne, Tammy

“…A problem inherent to the use of cellular assays for drug discovery is their sensitivity to cytotoxic compounds, which can result in false hits from certain…”
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Insights into the Branched-Chain Formation of Mycarose: Methylation Catalyzed by an (S)-Adenosylmethionine-Dependent Methyltransferase by Chen, Huawei, Zhao, Zongbao, Hallis, Tina M., Guo, Zhihong, Liu, Hung-wen

“…A C‐methyltransferase involved in methyl‐branch formation in sugars has been characterized for the first time. TylC3, an…”
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New Insights into the Mechanism of CDP-d-Tyvelose 2-Epimerase:  An Enzyme-Catalyzing Epimerization at an Unactivated Stereocenter by Hallis, Tina M, Zhao, Zongbao, Liu, Hung-wen

“…Tyvelose is a 3,6-dideoxyhexose found in the O-antigen of Yersinia pseudotuberculosis IVA and is the only member of this class of sugars to be produced…”
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Mechanistic Studies of the Biosynthesis of Tyvelose:  Purification and Characterization of CDP-d-tyvelose 2-Epimerase by Hallis, Tina M, Liu, Hung-wen

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Mechanistic Studies of the Biosynthesis of Paratose:  Purification and Characterization of CDP-paratose Synthase by Hallis, Tina M, Lei, Yenyoung, Que, Nanette L. S, Liu, Hung-wen

“…The 3,6-dideoxyhexoses can be found in the cell wall lipopolysaccharide of Gram-negative bacteria, where they have been shown to be the dominant antigenic…”
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Insights into the Branched-Chain Formation of Mycarose: Methylation Catalyzed by an (S)-Adenosylmethionine-Dependent Methyltransferase We are grateful to Dr. Eugene Seno and the Lilly Research Laboratories for their generous gift of the plasmid pHJL311 and to the National Institutes of Health for grants (GM 35 906 and 54 346). H.-w.L. also thanks the National Institute of General Medical Sciences for a MERIT Award. T.M.H. was a trainee of the National Institute of General Medical Sciences (Biote by Chen, Huawei, Zhao, Zongbao, Hallis, Tina M., Guo, Zhihong, Liu Hw, Hung-wen

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Fluorescent cascade and direct assays for characterization of RAF signaling pathway inhibitors by Kupcho, Kevin R, Bruinsma, Rica, Hallis, Tina M, Lasky, David A, Somberg, Richard L, Turek-Etienne, Tammy, Vogel, Kurt W, Huwiler, Kristin G

“…RAF kinases are part of a conserved signaling pathway that impacts cell growth, differentiation, and survival, and RAF pathway dysregulation is an attractive…”
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Covalent Peroxisome Proliferator-activated Receptor γ Adduction by Nitro-fatty Acids by Schopfer, Francisco J., Cole, Marsha P., Groeger, Alison L., Chen, Chen-Shan, Khoo, Nicholas K.H., Woodcock, Steven R., Golin-Bisello, Franca, Motanya, U.Nkiru, Li, Yong, Zhang, Jifeng, Garcia-Barrio, Minerva T., Rudolph, Tanja K., Rudolph, Volker, Bonacci, Gustavo, Baker, Paul R.S., Xu, H.Eric, Batthyany, Carlos I., Chen, Y.Eugene, Hallis, Tina M., Freeman, Bruce A.

“…The peroxisome proliferator-activated receptor-γ (PPARγ) binds diverse ligands to transcriptionally regulate metabolism and inflammation. Activators of PPARγ…”
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The Biosynthesis of GDP- l -Colitose:  C-3 Deoxygenation Is Catalyzed by a Unique Coenzyme B 6 -Dependent Enzyme by Beyer, Noelle, Alam, Jenefer, Hallis, Tina M., Guo, Zhihong, Liu, Hung-wen

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Stereospecificity of hydride transfer for the catalytically recycled NAD + in CDP- d-glucose 4,6-dehydratase by Hallis, Tina M., Liu, Hung-wen

“…CDP-D-glucose 4,6-dehydratase (E od), found in the biosynthetic pathway of 3,6-dideoxysugars, contains a tightly bound NAD + that is recycled during catalysis…”
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Insights into the Branched-Chain Formation of Mycarose: Methylation Catalyzed by an (S)-Adenosylmethionine-Dependent Methyltransferase by Chen, Huawei, Zhao, Zongbao, Hallis, Tina M., Guo, Zhihong, Liu, Hung-wen

“…Eine C‐Methyltransferase, die am Aufbau von Methylverzweigungen in Zuckern beteiligt ist, wurde erstmals charakterisiert. TylC3, ein…”
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Fluorescent Cascade and Direct Assays for Characterization of RAF Signaling Pathway Inhibitors by Kupcho, Kevin R, Bruinsma, Rica, Hallis, Tina M, Lasky, David A, Somberg, Richard L, Turek-Etienne, Tammy, Vogel, Kurt W, Huwiler, Kristin G

“…RAF kinases are part of a conserved signaling pathway that impacts cell growth, differentiation, and survival, and RAF pathway dysregulation is an attractive…”
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