Search Results - "Halliday, Mark"
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Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice
Published in Science translational medicine (09-10-2013)“…During prion disease, an increase in misfolded prion protein (PrP) generated by prion replication leads to sustained overactivation of the branch of the…”
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Review: Modulating the unfolded protein response to prevent neurodegeneration and enhance memory
Published in Neuropathology and applied neurobiology (01-06-2015)“…Recent evidence has placed the unfolded protein response (UPR) at the centre of pathological processes leading to neurodegenerative disease. The translational…”
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Prions: Generation and Spread Versus Neurotoxicity
Published in The Journal of biological chemistry (18-07-2014)“…Neurodegenerative diseases are characterized by the aggregation of misfolded proteins in the brain. Among these disorders are the prion diseases, which are…”
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Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21
Published in Cell reports (Cambridge) (07-08-2018)“…Stress adaptation is essential for neuronal health. While the fundamental role of mitochondria in neuronal development has been demonstrated, it is still not…”
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Reply: Trazodone to change the risk of neurodegeneration: bedside to bench
Published in Brain (London, England : 1878) (01-08-2017)Get full text
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A community health-coaching referral program following discharge from treatment for chronic low back pain - a qualitative study of the patient's perspective
Published in BMC health services research (16-09-2024)“…Global policy and guidelines for low back pain (LBP) management promote physical activity and self-management yet adherence is poor and a decline in outcomes…”
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A Randomized Controlled Trial Comparing the McKenzie Method to Motor Control Exercises in People With Chronic Low Back Pain and a Directional Preference
Published in The journal of orthopaedic and sports physical therapy (01-07-2016)“…Study Design Randomized clinical trial. Background Motor control exercises are believed to improve coordination of the trunk muscles. It is unclear whether…”
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What Is Our Current Understanding of PrPSc-Associated Neurotoxicity and Its Molecular Underpinnings?
Published in Pathogens (Basel) (01-12-2017)“…The prion diseases are a collection of fatal, transmissible neurodegenerative diseases that cause rapid onset dementia and ultimately death. Uniquely, the…”
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Treatment Effect Sizes of Mechanical Diagnosis and Therapy for Pain and Disability in Patients With Low Back Pain: A Systematic Review
Published in The journal of orthopaedic and sports physical therapy (01-04-2019)“…Mechanical Diagnosis and Therapy (MDT) is a treatment-based classification system founded on 3 core principles: classification into diagnostic syndromes,…”
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A randomized clinical trial comparing the McKenzie method and motor control exercises in people with chronic low back pain and a directional preference: 1-year follow-up
Published in Physiotherapy (01-12-2019)“…The primary objective of this study was to compare the long-term (1-year follow-up) effects of the McKenzie method and motor control exercises on trunk muscle…”
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Health coaching intervention with or without the support of an exercise buddy to increase physical activity of people with chronic low back pain compared to usual care: a feasibility and pilot randomised controlled trial
Published in Musculoskeletal science & practice (01-06-2024)“…Exercise buddies (people to exercise together with) might support people with low back pain (LBP) to become active. However, involving buddies in randomised…”
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Effectiveness of a coordinated support system linking public hospitals to a health coaching service compared with usual care at discharge for patients with chronic low back pain: protocol for a randomised controlled trial
Published in BMC musculoskeletal disorders (09-07-2021)“…Abstract Background Although many people with chronic low back pain (LBP) improve following conservative treatment, one in five will experience worsening…”
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Promotion of Physical Activity by Health Professionals (PROMOTE-PA): protocol for effectiveness outcomes in a hybrid type I effectiveness-implementation cluster randomised controlled trial
Published in BMJ nutrition, prevention & health (06-08-2024)“…Promotion of physical activity by health professionals can increase physical activity participation among patients, however, implementing physical activity…”
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A randomized controlled trial comparing McKenzie therapy and motor control exercises on the recruitment of trunk muscles in people with chronic low back pain: a trial protocol
Published in Physiotherapy (01-06-2015)“…Abstract Objective To investigate if McKenzie exercises when applied to a cohort of patients with chronic LBP who have a directional preference demonstrate…”
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Systemic Low-Dose UVB Inhibits CD8 T Cells and Skin Inflammation by Alternative and Novel Mechanisms
Published in The American journal of pathology (01-06-2011)“…Exposure to UVB radiation before antigen delivery at an unirradiated site inhibits functional immunological responses. Mice treated dorsally with suberythemal…”
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Jack Gilbert Looking Back on Long Life
Published in Literary imagination (31-12-2022)Get full text
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Kenneth Fearing and Human Lifetimes
Published in Literary imagination (01-11-2021)Get full text
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Ruptured ileocolic artery aneurysm: an unusual cause of hemoperitoneum
Published in Saudi journal of gastroenterology (01-09-2012)“…Ruptured aneurysm of a branch of ileocolic artery is a rare finding and is an unusual cause of haemoperitoneum. Rapid diagnosis, and surgical or endovascular…”
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Fine‐tuning PERK signaling for neuroprotection
Published in Journal of neurochemistry (01-09-2017)“…Protein translation and folding are tightly controlled processes in all cells, by proteostasis, an important component of which is the unfolded protein…”
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Tony Hoagland and Self-Criticism
Published in Literary imagination (01-07-2019)Get full text
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