Search Results - "Halliday, Glenda M."

Glia: Initiators and progressors of pathology in Parkinson's disease by Halliday, Glenda M., Stevens, Claire H.

“…Background: Glia are traditionally known as support cells for neurons, and their role in neurodegeneration has been largely considered secondary to neuronal…”
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Toll-like receptor 2 is increased in neurons in Parkinson’s disease brain and may contribute to alpha-synuclein pathology by Dzamko, Nicolas, Gysbers, Amanda, Perera, Gayathri, Bahar, Anita, Shankar, Amrita, Gao, Jianqun, Fu, YuHong, Halliday, Glenda M.

“…Inflammation is likely a key contributor to the pathogenesis of Parkinson’s disease (PD), a progressively debilitating neurodegenerative disease that is…”
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The frontotemporal dementia-motor neuron disease continuum by Burrell, James R, PhD, Halliday, Glenda M, Prof, Kril, Jillian J, Prof, Ittner, Lars M, Prof, Götz, Jürgen, Prof, Kiernan, Matthew C, Prof, Hodges, John R, Prof

“…Summary Early reports of cognitive and behavioural deficits in motor neuron disease might have been overlooked initially, but the concept of a frontotemporal…”
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Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts by Strohäker, Timo, Jung, Byung Chul, Liou, Shu-Hao, Fernandez, Claudio O., Riedel, Dietmar, Becker, Stefan, Halliday, Glenda M., Bennati, Marina, Kim, Woojin S., Lee, Seung-Jae, Zweckstetter, Markus

“…Parkinson’s disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive diseases that feature a common neuropathological hallmark of aggregated…”
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Disease duration and the integrity of the nigrostriatal system in Parkinson's disease by KORDOWER, Jeffrey H, WARREN OLANOW, C, DODIYA, Hemraj B, YAPING CHU, BEACH, Thomas G, ADLER, Charles H, HALLIDAY, Glenda M, BARTUS, Raymond T

“…The pace of nigrostriatal degeneration, both with regards to striatal denervation and loss of melanin and tyrosine hydroxylase-positive neurons, is poorly…”
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Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders by Werry, Eryn L, Bright, Fiona M, Piguet, Olivier, Ittner, Lars M, Halliday, Glenda M, Hodges, John R, Kiernan, Matthew C, Loy, Clement T, Kril, Jillian J, Kassiou, Michael

“…Neuroinflammation is an inflammatory response in the brain and spinal cord, which can involve the activation of microglia and astrocytes. It is a common…”
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Cognitive fluctuations in Lewy body dementia: towards a pathophysiological framework by Matar, Elie, Shine, James M, Halliday, Glenda M, Lewis, Simon J G

“…Fluctuating cognition is a complex and disabling symptom that is seen most frequently in the context of Lewy body dementias encompassing dementia with Lewy…”
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TDP-43 proteinopathies: a new wave of neurodegenerative diseases by de Boer, Eva Maria Johanna, Orie, Viyanti K, Williams, Timothy, Baker, Mark R, De Oliveira, Hugo M, Polvikoski, Tuomo, Silsby, Matthew, Menon, Parvathi, van den Bos, Mehdi, Halliday, Glenda M, van den Berg, Leonard H, Van Den Bosch, Ludo, van Damme, Philip, Kiernan, Matthew C, van Es, Michael A, Vucic, Steve

“…Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are evident in the brain and spinal cord of patients that present across a…”
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Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism by Prusiner, Stanley B., Woerman, Amanda L., Mordes, Daniel A., Watts, Joel C., Rampersaud, Ryan, Berry, David B., Patel, Smita, Oehler, Abby, Lowe, Jennifer K., Kravitz, Stephanie N., Geschwind, Daniel H., Glidden, David V., Halliday, Glenda M., Middleton, Lefkos T., Gentleman, Steve M., Grinberg, Lea T., Giles, Kurt

“…Prions are proteins that adopt alternative conformations that become self-propagating; the PrPScprion causes the rare human disorder Creutzfeldt–Jakob disease…”
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The neurobiological basis of cognitive impairment in Parkinson's disease by Halliday, Glenda M., Leverenz, James B., Schneider, Jay S., Adler, Charles H.

“…ABSTRACT The recent formalization of clinical criteria for Parkinson's disease with dementia (PDD) codifies many studies on this topic, including those…”
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Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria by Dickson, Dennis W, MD, Braak, Heiko, MD, Duda, John E, MD, Duyckaerts, Charles, MD, Gasser, Thomas, MD, Halliday, Glenda M, PhD, Hardy, John, PhD, Leverenz, James B, MD, Del Tredici, Kelly, MD, Wszolek, Zbigniew K, MD, Litvan, Irene, MD

“…Summary To date, there have been few systematic attempts to provide a standard operating procedure for the neuropathological diagnosis of Parkinson's disease…”
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Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease by Berg, Daniela, Postuma, Ronald B., Bloem, Bastiaan, Chan, Piu, Dubois, Bruno, Gasser, Thomas, Goetz, Christopher G., Halliday, Glenda M., Hardy, John, Lang, Anthony E., Litvan, Irene, Marek, Kenneth, Obeso, José, Oertel, Wolfgang, Olanow, C. Warren, Poewe, Werner, Stern, Matthew, Deuschl, Günther

“…ABSTRACT With advances in knowledge disease, boundaries may change. Occasionally, these changes are of such a magnitude that they require redefinition of the…”
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Loss of the metabolism and sleep regulating neuronal populations expressing orexin and oxytocin in the hypothalamus in amyotrophic lateral sclerosis by Gabery, Sanaz, Ahmed, Rebekah M, Caga, Jashelle, Kiernan, Matthew C, Halliday, Glenda M, Petersén, Åsa

“…Aims To determine the underlying cellular changes and clinical correlates associated with pathology of the hypothalamus in amyotrophic lateral sclerosis (ALS),…”
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Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease by Murphy, Karen E., Gysbers, Amanda M., Abbott, Sarah K., Spiro, Adena S., Furuta, Akiko, Cooper, Antony, Garner, Brett, Kabuta, Tomohiro, Halliday, Glenda M.

“…ABSTRACT Lysosomes are the primary catabolic compartment for the degradation of intracellular proteins through autophagy. The presence of abnormal…”
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Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies by Forrest, Shelley L, Kril, Jillian J, Stevens, Claire H, Kwok, John B, Hallupp, Marianne, Kim, Woojin S, Huang, Yue, McGinley, Ciara V, Werka, Hellen, Kiernan, Matthew C, Götz, Jürgen, Spillantini, Maria Grazia, Hodges, John R, Ittner, Lars M, Halliday, Glenda M

“…See Josephs (doi:10.1093/brain/awx367) for a scientific commentary on this article. Mutations in the MAPT gene on chromosome 17 are associated with…”
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Amyotrophic lateral sclerosis and frontotemporal dementia: distinct and overlapping changes in eating behaviour and metabolism by Ahmed, Rebekah M, Dr, Irish, Muireann, PhD, Piguet, Olivier, PhD, Halliday, Glenda M, Prof, Ittner, Lars M, Prof, Farooqi, Sadaf, Prof, Hodges, John R, Prof, Kiernan, Matthew C, Prof

“…Summary Metabolic changes incorporating fluctuations in weight, insulin resistance, and cholesterol concentrations have been identified in several…”
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LRRK2‐mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients by Atashrazm, Farzaneh, Hammond, Deborah, Perera, Gayathri, Bolliger, Marc F., Matar, Elie, Halliday, Glenda M., Schüle, Birgitt, Lewis, Simon J.G., Nichols, R. Jeremy, Dzamko, Nicolas

“…Background Leucine‐rich repeat kinase 2 is a potential therapeutic target for the treatment of Parkinson's disease, and clinical trials of leucine‐rich repeat…”
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The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years by Hely, Mariese A., Reid, Wayne G.J., Adena, Michael A., Halliday, Glenda M., Morris, John G.L.

“…After 20 years follow‐up of newly diagnosed patients with Parkinson's disease (PD), 100 of 136 (74%) have died. The mortality rate fell in the first 3 years of…”
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Role of the Long Non-Coding RNA MAPT-AS1 in Regulation of Microtubule Associated Protein Tau (MAPT) Expression in Parkinson's Disease by Coupland, Kirsten G, Kim, Woojin S, Halliday, Glenda M, Hallupp, Marianne, Dobson-Stone, Carol, Kwok, John B J

“…Studies investigating the pathogenic role of the microtubule associated protein tau (MAPT) gene in Parkinson's disease (PD) have indicated that DNA methylation…”
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Neuronal network disintegration: common pathways linking neurodegenerative diseases by Ahmed, Rebekah M, Devenney, Emma M, Irish, Muireann, Ittner, Arne, Naismith, Sharon, Ittner, Lars M, Rohrer, Jonathan D, Halliday, Glenda M, Eisen, Andrew, Hodges, John R, Kiernan, Matthew C

“…Neurodegeneration refers to a heterogeneous group of brain disorders that progressively evolve. It has been increasingly appreciated that many…”
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