Plasma glucose and insulin response to two oral nutrition supplements in adults with type 2 diabetes mellitus

The purpose of this clinical trial was to compare the glucose usage of two oral nutritional supplement (ONS) products and to assess whether a diabetes-specific formulation provides improved glucose stabilization and management compared with a standard formula. A total of 12 subjects with type 2 diab...

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Bibliographic Details
Published in:	BMJ open diabetes research & care Vol. 4; no. 1; p. e000240
Main Authors:	Huhmann, Maureen B, Smith, Kristen N, Schwartz, Sherwyn L, Haller, Stacie K, Irvin, Sarah, Cohen, Sarah S
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group 01-01-2016
Subjects:	Clinical Care/Education/Nutrition/Psychosocial Research Nutrition Nutritional Intervention
Online Access:	Get full text
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Summary:	The purpose of this clinical trial was to compare the glucose usage of two oral nutritional supplement (ONS) products and to assess whether a diabetes-specific formulation provides improved glucose stabilization and management compared with a standard formula. A total of 12 subjects with type 2 diabetes (7 males and 5 females) completed a randomized, cross-over design trial. Each subject consumed isocaloric amounts of either the standard ONS or the diabetes-specific formula ONS on different dates, 1 week apart. Glucose and insulin measures were recorded at baseline, and 10, 20, 30, 60, 90, 120, 150, 180, 210 and 240 min after the beverage was consumed and then used to calculate area under the curve (AUC) for each subject. The mean glucose AUC was lower in the diabetes-specific ONS group than in the standard group (p<0.0001), but there was not a significant difference observed for mean insulin AUC (p=0.068). A sensitivity analysis of the mean insulin AUC measures was performed by removing a potential outlier from the analysis, and this resulted in a significant difference between the groups (p=0.012). First-phase insulin measures and an insulinogenic index calculated for the beverages showed no significant differences. On the basis of the results of this trial of 12 subjects, the diabetes-specific ONS appears to provide better glucose maintenance in persons with type 2 diabetes when compared to the standard formula ONS. NCT02612675.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2052-4897 2052-4897
DOI:	10.1136/bmjdrc-2016-000240