Search Results - "Hallenbeck, J M"

Elevated pro-inflammatory CD4+CD28- lymphocytes and stroke recurrence and death by NADAREISHVILI, Z. G, LI, H, WRIGHT, V, MARIC, D, WARACH, S, HALLENBECK, J. M, DAMBROSIA, J, BARKER, J. L, BAIRD, A. E

“…To determine if the CD4+CD28- T-cell subset is expanded in patients with recurrent stroke or death after acute ischemic stroke. This subset of the peripheral…”
Get full text

Growth Arrest and DNA Damage-Inducible Protein GADD34 Assembles a Novel Signaling Complex Containing Protein Phosphatase 1 and Inhibitor 1 by Connor, John H., Weiser, Douglas C., Li, Shi, Hallenbeck, John M., Shenolikar, Shirish

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke by KOCHANEK, P. M, HALLENBECK, J. M

“…The extent to which polymorphonuclear leukocytes and monocytes/macrophages contribute to the pathobiology of cerebral ischemia and stroke is an issue of…”
Get full text

Advances in the Vascular Pathophysiology of Ischemic Stroke by del Zoppo, Gregory J, Hallenbeck, John M

“…The cerebral vascular supply is constructed to protect the cerebral hemispheres and brainstem from the consequences of blood flow cessation. Reversal of blood…”
Get full text

TNF-alpha pretreatment induces protective effects against focal cerebral ischemia in mice by Nawashiro, H, Tasaki, K, Ruetzler, C A, Hallenbeck, J M

“…Cytokines are recognized to play an important role in acute stroke. Tumor necrosis factor-alpha (TNF) is one of the pro-inflammatory cytokines and is expressed…”
Get more information

Acute focal ischemia-induced alterations in MAP2 immunostaining: description of temporal changes and utilization as a marker for volumetric assessment of acute brain injury by Dawson, D A, Hallenbeck, J M

“…The utility of microtubule-associated protein 2 (MAP2) immunostaining as a marker of acute focal ischemic injury was investigated. Permanent middle cerebral…”
Get more information

Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody : A bedside-to-bench study by FURUYA, Kazuhide, TAKEDA, Hidetaka, DEL ZOPPO, Gregory J, HALLENBECK, John M, AZHAR, Salman, MCCARRON, Richard M, YONG CHEN, RUETZLER, Christl A, WOLCOTT, Karen M, DEGRABA, Thomas J, ROTHLEIN, Robert, HUGLI, Tony E

“…Enlimomab, a murine monoclonal anti-human intercellular adhesion molecule (ICAM)-1 antibody, had a negative outcome in a multicenter acute-stroke trial. We did…”
Get full text

Interleukin-1 beta mRNA expression in ischemic rat cortex by Liu, T, McDonnell, P C, Young, P R, White, R F, Siren, A L, Hallenbeck, J M, Barone, F C, Feurestein, G Z

“…Interleukin-1 beta is a proinflammatory cytokine produced by blood-borne and resident brain inflammatory cells. The present study was conducted to determine if…”
Get full text

High Susceptibility to Cerebral Ischemia in GFAP-Null Mice by Nawashiro, Hiroshi, Brenner, Michael, Fukui, Shinji, Shima, Katsuji, Hallenbeck, John M.

“…Astrocytes perform a variety of functions in the adult central nervous system (CNS) that contribute to the survival of neurons. Thus, it is likely that the…”
Get full text

Inhibition of tumor necrosis factor and amelioration of brain infarction in mice by Nawashiro, H, Martin, D, Hallenbeck, J M

“…Tumor necrosis factor alpha (TNF-alpha) is expressed in the ischemic brain; however, its precise role is not fully understood. We studied the effect of the…”
Get more information

Hibernation in ground squirrels induces state and species-specific tolerance to hypoxia and aglycemia: an in vitro study in hippocampal slices by Frerichs, K U, Hallenbeck, J M

“…Hibernation in mammals is associated with a regulated depression of global cellular functions accompanied by reductions of cerebral blood flow that would…”
Get more information

Inhibition of tumor necrosis factor-alpha reduces focal cerebral ischemic injury in the spontaneously hypertensive rat by Dawson, Deborah A., Martin, David, Hallenbeck, John M.

“…Tumor necrosis factor-alpha (TNF-α) is acutely expressed following focal cerebral ischemia, but its pathophysiological role remains to be extensively…”
Get full text

Cerebrovascular Hemodynamics and Ischemic Tolerance: Lipopolysaccharide-Induced Resistance to Focal Cerebral Ischemia Is Not Due to Changes in Severity of the Initial Ischemic Insult, but Is Associated With Preservation of Microvascular Perfusion by Dawson, Deborah A., Furuya, Kazuhide, Gotoh, Jun, Nakao, Yasuaki, Hallenbeck, John M.

“…Lipopolysaccharide (LPS), administered 72 hours before middle cerebral artery (MCA) occlusion, confers significant protection against ischemic injury. For…”
Get full text

The many faces of tumor necrosis factor in stroke by Hallenbeck, John M

“…The cytokine, TNF, participates in virtually every aspect of stroke. Its effects, however, often appear contradictory. Analysis of the current model for TNF…”
Get full text

The Protective Effect of Ceramide in Immature Rat Brain Hypoxia-Ischemia Involves Up-regulation of Bcl-2 and Reduction of TUNEL-Positive Cells by Chen, Yong, Ginis, Irene, Hallenbeck, John M.

“…Preconditioning brain with tumor necrosis factor alpha (TNF-α) can induce tolerance to experimental hypoxia and stroke and ceramide is a downstream messenger…”
Get full text

Ischemic tolerance and endogenous neuroprotection by Dirnagl, Ulrich, Simon, Roger P., Hallenbeck, John M.

“…Practically any stimulus capable of causing injury to a tissue or organ can, when applied close to (but below) the threshold of damage, activate endogenous…”
Get full text

Mechanisms for Increased Levels of Phosphorylation of Elongation Factor-2 during Hibernation in Ground Squirrels by Chen, Yun, Matsushita, Masayuki, Nairn, Angus C, Damuni, Zahi, Cai, Decheng, Frerichs, Kai U, Hallenbeck, John M

“…Previously, eEF-2 phosphorylation has been identified as a reversible mechanism involved in the inhibition of the elongation phase of translation. In this…”
Get full text

Evidence for activation of endothelium and monocytes in hypertensive rats by Liu, Y, Liu, T, McCarron, R M, Spatz, M, Feuerstein, G, Hallenbeck, J M, Sirén, A L

“…We have proposed that an interaction between perivascular macrophages and endothelium via cytokines could underlie the increased risk of stroke in…”
Get full text

Local cerebral blood flow during hibernation, a model of natural tolerance to "cerebral ischemia" by Frerichs, K U, Kennedy, C, Sokoloff, L, Hallenbeck, J M

“…The breakdown of cellular homeostasis and progressive neuronal destruction in cerebral ischemia appears to be mediated by a complex network of causes that are…”
Get more information

Increased endothelial expression of intercellular adhesion molecule-1 in symptomatic versus asymptomatic human carotid atherosclerotic plaque by DEGRABA, T. J, SIREN, A.-L, PENIX, L, MCCARRON, R. M, HARGRAVES, R, SOOD, S, PETTIGREW, K. D, HALLENBECK, J. M

“…The mechanisms that cause carotid atherosclerotic plaque to become symptomatic remain unclear. Evidence suggests that mediators of inflammation are not only…”
Get full text