Search Results - "Halleen, J M"

Estrogen receptor specificity in the regulation of the skeleton in female mice by Lindberg, MK, Alatalo, SL, Halleen, JM, Mohan, S, Gustafsson, JA, Ohlsson, C

“…There are two known estrogen receptors, estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta), which may mediate the actions of estrogen. The…”
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Tartrate‐Resistant Acid Phosphatase 5b: A Novel Serum Marker of Bone Resorption by Halleen, Jussi M., Alatalo, Sari L., Suominen, Harri, Cheng, Sulin, Janckila, Anthony J., Väänänen, H. Kalervo

“…Human serum contains two forms of tartrate‐resistant acid phosphatase (TRAP), 5a and 5b. Of these, 5a contains sialic acid and 5b does not. We show here that…”
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The anti-tumor agent sagopilone shows antiresorptive effects both in vitro and in vivo by Strube, A., Suominen, M. I., Rissanen, J. P., Mumberg, D., Klar, U., Halleen, J. M., Käkönen, S.-M.

“…Summary Sagopilone, a fully synthetic epothilone and very potent anti-tumor agent, has proved to be efficient in inhibiting bone destruction and tumor burden…”
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Estrogen receptor alpha, but not estrogen receptor beta, is involved in the regulation of the OPG/RANKL (osteoprotegerin/receptor activator of NF-kappa B ligand) ratio and serum interleukin-6 in male mice by Lindberg, MK, Erlandsson, M, Alatalo, SL, Windahl, S, Andersson, G, Halleen, JM, Carlsten, H, Gustafsson, JA, Ohlsson, C

“…Estrogens are important for the male skeleton. Osteoprotegerin (OPG), receptor activator of NF-kappa B ligand (RANKL), interleukin-6 (IL-6), IL-1 and tumor…”
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Serum tartrate-resistant acid phosphatase 5b is a specific and sensitive marker of bone resorption by HALLEEN, Jussi M, ALATALO, Sari L, JANCKILA, Anthony J, WOITGE, Henning W, SEIBEL, Markus J, VÄÄNÄNEN, H. Kalervo

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Endogenous expression and endocytosis of tartrate-resistant acid phosphatase (TRACP) by osteoblast-like cells by Perez-Amodio, S., Vogels, I.M.C., Schoenmaker, T., Jansen, D.C., Alatalo, S.L., Halleen, J.M., Beertsen, W., Everts, V.

“…Tartrate-resistant acid phosphatase (TRACP) is produced by macrophages and other cells of the monohistiocytic lineage. In particular, osteoclasts are…”
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Serum TRACP 5b and ICTP as Markers of Bone Metastases in Breast Cancer by KORPELA, J, TIITINEN, S. L, HIEKKANEN, H, HALLEEN, J. M, SELANDER, K. S, VÄÄNÄNEN, H. K, SUOMINEN, P, HELENIUS, H, SALMINEN, E

“…Background: The purpose of this cross-sectional study was to evaluate the value of serum tartrate-resistant acid phosphatase 5b (TRACP 5b) and carboxyterminal…”
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Rapid Screening Method for Osteoclast Differentiation in Vitro That Measures Tartrate-resistant Acid Phosphatase 5b Activity Secreted into the Culture Medium by Alatalo, Sari L, Halleen, Jussi M, Hentunen, Teuvo A, Monkkonen, Jukka, Vaananen, H. Kalervo

“…Osteoclasts secrete tartrate-resistant acid phosphatase (TRAP; EC 3.1.3.2) 5b into the circulation. We studied the release of TRAP 5b from osteoclasts using a…”
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Serum tartrate-resistant acid phosphatase 5b (TRACP 5b) as a marker of skeletal changes in prostate cancer by Salminen, Eeva, Ala-Houhala, M, Korpela, J, Varpula, M, Tiitinen, S L, Halleen, J M, Väänänen, H K

“…Skeletal metastases are a significant problem in prostate cancer (PC). The patients are also exposed to treatment-related skeletal changes. This…”
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Clinical Significance of Immunoassays for Type-5 Tartrate-resistant Acid Phosphatase by Nakasato, Yuri R, Janckila, Anthony J, Halleen, Jussi M, Vaananen, H. Kalervo, Walton, Stephanie P, Yam, Lung T

“…Tartrate-resistant acid phosphatase (TRAP; EC 3.1.3.2) is a product of osteoclasts and a biochemical marker of bone resorption rate. However, erythrocytes and…”
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The cell biology of osteoclast function by Väänänen, H K, Zhao, H, Mulari, M, Halleen, J M

“…Osteoclasts are multinucleated cells responsible for bone resorption. They have developed an efficient machinery for dissolving crystalline hydroxyapatite and…”
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Characterization of Serum Tartrate‐Resistant Acid Phosphatase and Development of a Direct Two‐Site Immunoassay by Halleen, Jussi M., Hentunen, Teuvo A., Karp, Matti, Käkönen, Sanna‐Maria, Pettersson, Kim, Väänänen, H. Kalervo

“…Osteoclasts secrete tartrate‐resistant acid phosphatase (TRAP) to the circulation, where the amount of TRAP is expected to correlate with the bone resorption…”
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Biochemical Markers of Bone Metabolism and Prediction of Fracture in Elderly Women by Gerdhem, Paul, Ivaska, Kaisa K, Alatalo, Sari L, Halleen, Jussi M, Hellman, Jukka, Isaksson, Anders, Pettersson, Kim, Väänänen, H Kalervo, Åkesson, Kristina, Obrant, Karl J

“…We studied the ability of various markers of bone turnover to predict fracture in 1040 randomly recruited 75‐year‐old women. A total of 178 of the women…”
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Two‐Site Immunoassays for Osteoclastic Tartrate‐Resistant Acid Phosphatase Based on Characterization of Six Monoclonal Antibodies by Halleen, Jussi M., Karp, Matti, Viloma, Sari, Laaksonen, Pirjo, Hellman, Jukka, Käkönen, Sanna‐Maria, Stepan, Jan J., Holmes, Stephen, Väänänen, H. Kalervo, Pettersson, Kim

“…Tartrate‐resistant acid phosphatase (TRAP), an enzyme expressed in bone‐resorbing osteoclasts, is secreted into the circulation during bone resorption. We used…”
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Serum TRACP 5b Is a Useful Marker for Monitoring Alendronate Treatment: Comparison With Other Markers of Bone Turnover by Nenonen, Arja, Cheng, Sulin, Ivaska, Kaisa K, Alatalo, Sari L, Lehtimäki, Terho, Schmidt‐Gayk, Heinrich, Uusi‐Rasi, Kirsti, Heinonen, Ari, Kannus, Pekka, Sievänen, Harri, Vuori, Ilkka, Väänänen, H Kalervo, Halleen, Jussi M

“…We studied clinical performance of serum TRACP 5b and other bone turnover markers, including S‐CTX, U‐DPD, S‐PINP, S‐BALP, and S‐OC, for monitoring alendronate…”
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Intracellular Machinery for Matrix Degradation in Bone‐Resorbing Osteoclasts by Vääräniemi, Jukka, Halleen, Jussi M, Kaarlonen, Katja, Ylipahkala, Hannele, Alatalo, Sari L, Andersson, Göran, Kaija, Helena, Vihko, Pirkko, Väänänen, H Kalervo

“…In osteoclasts, TRACP co‐localized with cathepsin K in transcytotic vesicles and was activated by cathepsin K in vitro, suggesting that TRACP may degrade…”
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Serum tartrate-resistant acid phosphatase 5b, but not 5a, correlates with other markers of bone turnover and bone mineral density by Halleen, J M, Ylipahkala, H, Alatalo, S L, Janckila, A J, Heikkinen, J E, Suominen, H, Cheng, S, Väänänen, H K

“…Human serum contains two isoforms of tartrate-resistant acid phosphatase (TRACP) known as TRACP 5a and TRACP 5b with pH optima of 5.0 and 5.8, respectively…”
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Macrophages overexpressing tartrate-resistant acid phosphatase show altered profile of free radical production and enhanced capacity of bacterial killing by Räisänen, Seija R., Alatalo, Sari L., Ylipahkala, Hannele, Halleen, Jussi M., Cassady, A. Ian, Hume, David A., Väänänen, H. Kalervo

“…Activated macrophages and osteoclasts express high amounts of tartrate-resistant acid phosphatase (TRACP, acp5). TRACP has a binuclear iron center with a…”
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Intracellular Fragmentation of Bone Resorption Products by Reactive Oxygen Species Generated by Osteoclastic Tartrate-resistant Acid Phosphatase by Halleen, Jussi M., Räisänen, Seija, Salo, Jari J., Reddy, Sakamuri V., Roodman, G. David, Hentunen, Teuvo A., Lehenkari, Petri P., Kaija, Helena, Vihko, Pirkko, Väänänen, H. Kalervo

“…Tartrate-resistant acid phosphatase (TRAP) is highly expressed in bone-resorbing osteoclasts and activated macrophages. It has been suggested that a…”
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Potential Function for the ROS‐Generating Activity of TRACP by Halleen, Jussi M, Räisänen, Seija R, Alatalo, Sari L, Väänänen, H Kalervo

“…TRACP is an enzyme with unknown biological function. It is expressed primarily in bone‐resorbing osteoclasts and activated macrophages. In addition to its…”
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