Search Results - "Halle, Bertil"

How amide hydrogens exchange in native proteins by Persson, Filip, Halle, Bertil

“…Amide hydrogen exchange (HX) is widely used in protein biophysics even though our ignorance about the HX mechanism makes data interpretation imprecise…”
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Thermal Signature of Hydrophobic Hydration Dynamics by Qvist, Johan, Halle, Bertil

“…Hydrophobic hydration, the perturbation of the aqueous solvent near an apolar solute or interface, is a fundamental ingredient in many chemical and biological…”
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Structural dynamics of supercooled water from quasielastic neutron scattering and molecular simulations by Qvist, Johan, Schober, Helmut, Halle, Bertil

“…One of the outstanding challenges presented by liquid water is to understand how molecules can move on a picosecond time scale despite being incorporated in a…”
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Transient Access to the Protein Interior: Simulation versus NMR by Persson, Filip, Halle, Bertil

“…Many proteins rely on rare structural fluctuations for their function, whereby solvent and other small molecules gain transient access to internal cavities. In…”
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Internal Water and Microsecond Dynamics in Myoglobin by Kaieda, Shuji, Halle, Bertil

“…Myoglobin (Mb) binds diatomic ligands, like O2, CO, and NO, in a cavity that is only transiently accessible. Crystallography and molecular simulations show…”
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Nuclear magnetic relaxation by the dipolar EMOR mechanism: Three-spin systems by Chang, Zhiwei, Halle, Bertil

“…In aqueous systems with immobilized macromolecules, including biological tissue, the longitudinal spin relaxation of water protons is primarily induced by…”
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Nuclear magnetic relaxation by the dipolar EMOR mechanism: General theory with applications to two-spin systems by Chang, Zhiwei, Halle, Bertil

“…In aqueous systems with immobilized macromolecules, including biological tissue, the longitudinal spin relaxation of water protons is primarily induced by…”
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Protein hydration dynamics in solution: a critical survey by Halle, Bertil, Halle, Bertil

“…The properties of water in biological systems have been studied for well over a century by a wide range of physical techniques, but progress has been slow and…”
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Hydration and Mobility of Trehalose in Aqueous Solution by Winther, Louise Revsbech, Qvist, Johan, Halle, Bertil

“…The disaccharide trehalose stabilizes proteins against unfolding, but the underlying mechanism is not well understood. Because trehalose is preferentially…”
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Cell water dynamics on multiple time scales by Persson, Erik, Halle, Bertil

“…Water-biomolecule interactions have been extensively studied in dilute solutions, crystals, and rehydrated powders, but none of these model systems may capture…”
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Flexibility and Packing in Proteins by Halle, Bertil

“…Structural flexibility is an essential attribute, without which few proteins could carry out their biological functions. Much information about protein…”
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Does the Dynamic Stokes Shift Report on Slow Protein Hydration Dynamics? by Halle, Bertil, Nilsson, Lennart

“…The time-dependent fluorescence frequency shift of protein-attached probes has a much slower decay than that for the free probe. The decay times, ranging from…”
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Biomolecular Cryocrystallography: Structural Changes during Flash-Cooling by Halle, Bertil, Petsko, Gregory A.

“…To minimize radiation damage, crystal structures of biological macromolecules are usually determined after rapid cooling to cryogenic temperatures, some…”
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Rotational dynamics in supercooled water from nuclear spin relaxation and molecular simulations by Qvist, Johan, Mattea, Carlos, Sunde, Erik P, Halle, Bertil

“…Structural dynamics in liquid water slow down dramatically in the supercooled regime. To shed further light on the origin of this super-Arrhenius temperature…”
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physical state of water in bacterial spores by Sunde, Erik P, Setlow, Peter, Hederstedt, Lars, Halle, Bertil

“…The bacterial spore, the hardiest known life form, can survive in a metabolically dormant state for many years and can withstand high temperatures, radiation,…”
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Molecular Origin of Time-Dependent Fluorescence Shifts in Proteins by Nilsson, Lennart, Halle, Bertil, Eisenthal, Kenneth B.

“…Time-resolved fluorescence spectroscopy is used increasingly to probe molecular motions at the aqueous interfaces of biological macromolecules and membranes…”
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dry ligand-binding cavity in a solvated protein by Qvist, Johan, Davidovic, Monika, Hamelberg, Donald, Halle, Bertil

“…Ligands usually bind to proteins by displacing water from the binding site. The affinity and kinetics of binding therefore depend on the hydration…”
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Nanosecond to Microsecond Protein Dynamics Probed by Magnetic Relaxation Dispersion of Buried Water Molecules by Persson, Erik, Halle, Bertil

“…Large-scale protein conformational motions on nanosecond−microsecond time scales are important for many biological processes, but remain largely unexplored…”
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Biomolecular Hydration: From Water Dynamics to Hydrodynamics by Halle, Bertil, Davidovic, Monika

“…Thermally driven rotational and translational diffusion of proteins and other biomolecules is governed by frictional coupling to their solvent environment…”
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Time scales of water dynamics at biological interfaces: peptides, proteins and cells by Qvist, Johan, Persson, Erik, Mattea, Carlos, Halle, Bertil

“…Water 2H and 17O spin relaxation is used to study water dynamics in the hydration layers of two small peptides, two globular proteins and in living cells of…”
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