Search Results - "Hallahan, Andrew R."

Clinical indicators for common paediatric conditions: Processes, provenance and products of the CareTrack Kids study by Wiles, Louise K, Hooper, Tamara D, Hibbert, Peter D, Molloy, Charlotte, White, Les, Jaffe, Adam, Cowell, Christopher T, Harris, Mark F, Runciman, William B, Schmiede, Annette, Dalton, Chris, Hallahan, Andrew R, Dalton, Sarah, Williams, Helena, Wheaton, Gavin, Murphy, Elisabeth, Braithwaite, Jeffrey

“…In order to determine the extent to which care delivered to children is appropriate (in line with evidence-based care and/or clinical practice guidelines…”
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Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade by Berman, David M., Karhadkar, Sunil S., Hallahan, Andrew R., Pritchard, Joel I., Eberhart, Charles G., Watkins, D. Neil, Chen, James K., Cooper, Michael K., Taipale, Jussi, Olson, James M., Beachy, Philip A.

“…Constitutive Hedgehog (Hh) pathway activity is associated with initiation of neoplasia, but its role in the continued growth of established tumors is unclear…”
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BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect by Olson, James M, Hallahan, Andrew R, Pritchard, Joel I, Chandraratna, Roshantha A S, Ellenbogen, Richard G, Geyer, J Russel, Overland, Ryan P, Strand, Andrew D, Tapscott, Stephen J

“…The mechanisms of retinoid activity in tumors remain largely unknown. Here we establish that retinoids cause extensive apoptosis of medulloblastoma cells. In a…”
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ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma by Ingram, Wendy J, Crowther, Lisa M, Little, Erica B, Freeman, Ruth, Harliwong, Ivon, Veleva, Desi, Hassall, Timothy E, Remke, Marc, Taylor, Michael D, Hallahan, Andrew R

“…Resistance to radiation treatment remains a major clinical problem for patients with brain cancer. Medulloblastoma is the most common malignant brain tumor of…”
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Quality of Health Care for Children in Australia, 2012-2013 by Braithwaite, Jeffrey, Hibbert, Peter D, Jaffe, Adam, White, Les, Cowell, Christopher T, Harris, Mark F, Runciman, William B, Hallahan, Andrew R, Wheaton, Gavin, Williams, Helena M, Murphy, Elisabeth, Molloy, Charlotte J, Wiles, Louise K, Ramanathan, Shanthi, Arnolda, Gaston, Ting, Hsuen P, Hooper, Tamara D, Szabo, Natalie, Wakefield, John G, Hughes, Clifford F, Schmiede, Annette, Dalton, Chris, Dalton, Sarah, Holt, Joanna, Donaldson, Liam, Kelley, Ed, Lilford, Richard, Lachman, Peter, Muething, Stephen

“…IMPORTANCE: The quality of routine care for children is rarely assessed, and then usually in single settings or for single clinical conditions. OBJECTIVE: To…”
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RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer by Julian, Elaine, Hallahan, Andrew R, Wainwright, Brandon J

“…The Notch signalling pathway plays crucial roles in neural development, functioning by preventing premature differentiation and promotion of glial cell fates…”
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p38 MAP kinase: a convergence point in cancer therapy by Olson, James M, Hallahan, Andrew R

“…Recent studies show that activation of p38 mitogen-activated protein kinase (MAPK) results in cancer cell apoptosis initiated by retinoids, cisplatin and other…”
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The Smo/Smo Model : Hedgehog-Induced Medulloblastoma with 90% Incidence and Leptomeningeal Spread by HATTON, Beryl A, VILLAVICENCIO, Elisabeth H, HALLAHAN, Andrew R, OLSON, James M, TSUCHIYA, Karen D, PRITCHARD, Joel I, DITZLER, Sally, PULLAR, Barbara, HANSEN, Stacey, KNOBLAUGH, Sue E, LEE, Donghoon, EBERHART, Charles G

“…Toward the goal of generating a mouse medulloblastoma model with increased tumor incidence, we developed a homozygous version of our ND2:SmoA1 model…”
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The SmoA1 mouse model reveals that Notch signaling is critical for the growth and survival of Sonic hedgehog-induced medulloblastomas by HALLAHAN, Andrew R, PRITCHARD, Joel I, OLSON, James M, HANSEN, Stacey, BENSON, Mark, STOECK, Jennifer, HATTON, Beryl A, RUSSELL, Thomas L, ELLENBOGEN, Richard G, BERNSTEIN, Irwin D, BEACHY, Phillip A

“…To develop a genetically faithful model of medulloblastoma with increased tumor incidence compared with the current best model we activated the Sonic Hedgehog…”
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The outcomes and treatment burden of childhood acute myeloid leukaemia in Australia, 1997-2008: A report from the Australian Paediatric Cancer Registry by Foresto, Steven A., Youlden, Danny R., Baade, Peter D., Hallahan, Andrew R., Aitken, Joanne F., Moore, Andrew S.

“…Childhood acute myeloid leukaemia (AML) requires intensive therapy and is associated with survival rates that are substantially inferior to many other…”
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Targeting the inhibitor of apoptosis proteins as a novel therapeutic strategy in medulloblastoma by Keating, Joanna, Tsoli, Maria, Hallahan, Andrew R, Ingram, Wendy J, Haber, Michelle, Ziegler, David S

“…Medulloblastoma is the most common malignant brain tumor of childhood. Novel therapeutic strategies are urgently needed to overcome cytotoxic resistance. We…”
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Conditional survival estimates for childhood cancer in Australia, 2002–2011: A population-based study by Youlden, Danny R, Baade, Peter D, Hallahan, Andrew R, Valery, Patricia C, Green, Adèle C, Aitken, Joanne F

“…Highlights • We examined how a child's survival outlook changes after a diagnosis of cancer. • Conditional survival was calculated for all children with cancer…”
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CareTrack Kids—part 1. Assessing the appropriateness of healthcare delivered to Australian children: study protocol for clinical indicator development by Wiles, Louise K, Hooper, Tamara D, Hibbert, Peter D, White, Les, Mealing, Nicole, Jaffe, Adam, Cowell, Christopher T, Harris, Mark F, Runciman, William B, Goldstein, Stan, Hallahan, Andrew R, Wakefield, John G, Murphy, Elisabeth, Lau, Annie, Wheaton, Gavin, Williams, Helena M, Hughes, Clifford, Braithwaite, Jeffrey

“…Introduction Despite the widespread availability of clinical guidelines, considerable gaps remain between the care that is recommended (appropriate care) and…”
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Proteomic profiling of high risk medulloblastoma reveals functional biology by Staal, Jerome A, Lau, Ling San, Zhang, Huizhen, Ingram, Wendy J, Hallahan, Andrew R, Northcott, Paul A, Pfister, Stefan M, Wechsler-Reya, Robert J, Rusert, Jessica M, Taylor, Michael D, Cho, Yoon-Jae, Packer, Roger J, Brown, Kristy J, Rood, Brian R

“…Genomic characterization of medulloblastoma has improved molecular risk classification but struggles to define functional biological processes, particularly…”
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CareTrack Kids—part 2. Assessing the appropriateness of the healthcare delivered to Australian children: study protocol for a retrospective medical record review by Hooper, Tamara D, Hibbert, Peter D, Mealing, Nicole, Wiles, Louise K, Jaffe, Adam, White, Les, Cowell, Christopher T, Harris, Mark F, Runciman, William B, Goldstein, Stan, Hallahan, Andrew R, Wakefield, John G, Murphy, Elisabeth, Lau, Annie, Wheaton, Gavin, Williams, Helena M, Hughes, Clifford, Braithwaite, Jeffrey

“…Introduction Australian and international clinical practice guidelines are available for common paediatric conditions. Yet there is evidence that there are…”
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Targeting Survivin with YM155 (Sepantronium Bromide): A novel therapeutic strategy for paediatric acute myeloid leukaemia by Smith, Amanda M, Little, Erica B, Zivanovic, Andjelija, Hong, Priscilla, Liu, Alfred K.S, Burow, Rachel, Stinson, Caedyn, Hallahan, Andrew R, Moore, Andrew S

“…Highlights • YM155 inhibits proliferation and induces apoptosis of AML in vitro. • Survivin mRNA and protein expression is downregulated in AML cells treated…”
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CareTrack Kids—part 3. Adverse events in children's healthcare in Australia: study protocol for a retrospective medical record review by Hibbert, Peter D, Hallahan, Andrew R, Muething, Stephen E, Lachman, Peter, Hooper, Tamara D, Wiles, Louise K, Jaffe, Adam, White, Les, Wheaton, Gavin R, Runciman, William B, Dalton, Sarah, Williams, Helena M, Braithwaite, Jeffrey

“…Introduction A high-quality health system should deliver care that is free from harm. Few large-scale studies of adverse events have been undertaken in…”
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Haemopoietic stem cell transplantation for children in Australia and New Zealand, 1998–2006: a report on behalf of the Australasian Bone Marrow Transplant Recipient Registry and the Australian and New Zealand Children's Haematology Oncology Group by Moore, Andrew S, Shaw, Peter J, Hallahan, Andrew R, Carter, Tina L, Kilo, Tatjana, Nivison‐Smith, Ian, O’Brien, Tracey A, Tapp, Heather, Teague, Lochie, Wilson, Shaun R, Tiedemann, Karin

“…Objective: To document haemopoietic stem cell transplantation (HSCT) activity and trends among paediatric patients in Australia and New Zealand. Design,…”
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Improved outcomes of children with malignancy admitted to a pediatric intensive care unit by HALLAHAN, Andrew R, SHAW, Peter J, ROWELL, Gregory, O'CONNELL, Anthony, SCHELL, David, GILLIS, Jonathan

“…To assess the acute and long-term outcomes of children admitted to the intensive care unit with cancer or complications after bone marrow transplantation…”
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A statistical method for predicting splice variants between two groups of samples using GeneChip expression array data by Fan, Wenhong, Khalid, Najma, Hallahan, Andrew R, Olson, James M, Zhao, Lue Ping

“…Alternative splicing of pre-messenger RNA results in RNA variants with combinations of selected exons. It is one of the essential biological functions and…”
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