Search Results - "Hallab, Nadim J"

Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: A novel mechanism for implant debris reactivity by Caicedo, Marco S., Desai, Ronak, McAllister, Kyron, Reddy, Anand, Jacobs, Joshua J., Hallab, Nadim J.

“…Immune reactivity to soluble and particulate implant debris remains the primary cause of aseptic inflammation and implant loosening. However, the intracellular…”
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Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms by Caicedo, Marco S., Samelko, Lauryn, McAllister, Kyron, Jacobs, Joshua J., Hallab, Nadim J.

“…Recent investigations indicate that innate immune “danger‐signaling” pathways mediate metal implant debris induced‐inflammatory responses, for example, NALP3…”
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Micrometer-sized titanium particles can induce potent Th2-type responses through TLR4-independent pathways by Mishra, Pankaj K, Wu, Wenhui, Rozo, Cristina, Hallab, Nadim J, Benevenia, Joseph, Gause, William C

“…Wear debris in joint replacements has been suggested as a cause of associated tissue-damaging inflammation. In this study, we examined whether solid titanium…”
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Cobalt-alloy implant debris induce HIF-1α hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure by Samelko, Lauryn, Caicedo, Marco S, Lim, Seung-Jae, Della-Valle, Craig, Jacobs, Joshua, Hallab, Nadim J

“…The historical success of orthopedic implants has been recently tempered by unexpected pathologies and early failures of some types of…”
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Influence of pH on the tribocorrosion behavior of CpTi in the oral environment: synergistic interactions of wear and corrosion by Mathew, Mathew T., Abbey, Savithri, Hallab, Nadim J., Hall, Deborah J., Sukotjo, Cortino, Wimmer, Markus A.

“…Dental implants made of titanium alloys have been used as a predictable therapy approach to replace missing teeth. The oral environment subjects titanium…”
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Metal-on-metal Bearing Surfaces by Jacobs, Joshua J, Urban, Robert M, Hallab, Nadim J, Skipor, Anastasia K, Fischer, Alfons, Wimmer, Markus A

“…Metal-on-metal bearing couples remain a popular option in total hip arthroplasty and are the only currently available option for surface replacement…”
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COVID-19 (SARS-CoV-2) lymphocyte responses are associated with inflammatory biomarkers in total joint replacement surgery candidates pre-operatively by Caicedo, Marco S, Flores, Vianey, Padilla, Alicia, Lauryn, Samelko, Jacobs, Joshua J, Hallab, Nadim J

“…Background Recent studies indicate that, in addition to antibody production, lymphocyte responses to SARS-CoV-2 may play an important role in protective…”
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Spinal implant debris-induced osteolysis by Hallab, Nadim J, Cunningham, Brian W, Jacobs, Joshua J

“…Generally, implant-induced osteolysis is a manifestation of an adverse cellular response to phagocytosable particulate wear and corrosion debris. Initially…”
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Biologic Responses to Orthopedic Implants: Innate and Adaptive Immune Responses to Implant Debris by Hallab, Nadim J

“…Almost 20% of joint replacement implants fail at 15 to 20 years. Reports suggest that systemic effects of metal-on-metal implants and local effects of total…”
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Metal Release in Patients Who Have Had a Primary Total Hip Arthroplasty. A Prospective, Controlled, Longitudinal Study by JACOBS, JOSHUA J, SKIPOR, ANASTASIA K, PATTERSON, LESLIE M, HALLAB, NADIM J, PAPROSKY, WAYNE G, BLACK, JONATHAN, GALANTE, JORGE O

“…There is an increasing recognition that, in the long term, total joint replacement may be associated with adverse local and remote tissue responses that are…”
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Evaluation and Treatment of Painful Total Hip Arthroplasties With Modular Metal Taper Junctions by Meneghini, R Michael, Hallab, Nadim J, Jacobs, Joshua J

“…Modern primary total hip arthroplasty femoral components have evolved to include modular necks. Subsequently, the additional taper junction provides another…”
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Characterization of residual debris on packaged hip arthroplasty stems demonstrates the dominance of less than 10 μm sized particulate: Updated USP788 guidelines for orthopedic implants by Hallab, Nadim J, Hallab, Salem R, Alexander, Anastasia, Pourzal, Robin

“…Past evaluation of particle contamination on packaged implants has typically been conducted using US Pharmacopeia (USP) 788, a 1970s pharmaceutical guideline…”
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Biological Responses to Spinal Implant Debris by Hallab, Nadim J.

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Orthopedic implant cobalt-alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and zirconium alloy-based particles in vitro, in human osteoblasts, fibroblasts, and macrophages by Dalal, Ali, Pawar, Vivek, McAllister, Kyron, Weaver, Carolyn, Hallab, Nadim J.

“…The performance of total joint arthroplasty (TJA) depends on the size/shape, material, and amounts of implant debris. Much remains unknown in terms of which…”
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Chemokines Associated with Pathologic Responses to Orthopedic Implant Debris by Hallab, Nadim J, Jacobs, Joshua J

“…Despite the success in returning people to health saving mobility and high quality of life, the over 1 million total joint replacements implanted in the US…”
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Biologic effects of implant debris by Hallab, Nadim J, Jacobs, Joshua J

“…Biologic response to orthopedic implants debris is central to clinical performance. Eventual implant loosening due to aseptic osteolysis has been attributed to…”
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TLR4 (not TLR2) dominate cognate TLR activity associated with CoCrMo implant particles by Samelko, Lauryn, Landgraeber, Stefan, McAllister, Kyron, Jacobs, Joshua, Hallab, Nadim J.

“…ABSTRACT Innate immune reactions to orthopedic implant debris are the primary cause of total joint replacement (TJR) failure over the long term (15–20 years)…”
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Local application of rhTGF-β2 enhances peri-implant bone volume and bone-implant contact in a rat model by De Ranieri, Aladino, Virdi, Amarjit S., Kuroda, Shinji, Shott, Susan, Leven, Robert M., Hallab, Nadim J., Sumner, Dale R.

“…Orthopedic and dental implant fixation depends upon bone regeneration. Growth factors such as transforming growth factor-beta (TGF-β) have been shown to…”
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Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton’s tyrosine kinase-dependent pathway by Mishra, Pankaj K., Palma, Mark, Buechel, Bonnie, Moore, Jeffrey, Davra, Viralkumar, Chu, Niansheng, Millman, Ariel, Hallab, Nadim J., Kanneganti, Thirumala-Devi, Birge, Raymond B., Behrens, Edward M., Rivera, Amariliz, Beebe, Kathleen S., Benevenia, Joseph, Gause, William C.

“…Initiation of the innate sterile inflammatory response that can develop in response to microparticle exposure is little understood. Here, we report that a…”
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In vitro simulation of fretting-corrosion in hip implant modular junctions: The influence of pH by Royhman, Dmitry, Patel, Megha, Jacobs, Joshua J., Wimmer, Markus A., Hallab, Nadim J., Mathew, Mathew T.

“…•This study evaluates the effects of pH variation on the wear and electrochemical properties of Ti6Al4V/CoCrMo couples, by simulating fretting-corrosion at…”
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