Search Results - "Hall, N."
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Nutrient sensing and TOR signaling in yeast and mammals
Published in The EMBO journal (15-02-2017)“…Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily conserved TOR (target of rapamycin) controls cell growth…”
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Antimicrobial Peptide Structure and Mechanism of Action: A Focus on the Role of Membrane Structure
Published in Current topics in medicinal chemistry (01-01-2016)“…Antimicrobial peptides (AMPs) are showing increasing promise as potential candidate antibacterial drugs in the face of the rapidly emerging bacterial…”
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Target of rapamycin (TOR) in nutrient signaling and growth control
Published in Genetics (Austin) (01-12-2011)“…TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a…”
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4
mTOR substrate phosphorylation in growth control
Published in Cell (26-05-2022)“…The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved serine/threonine protein kinase that plays a central role in regulating cell…”
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Determining Critical Nutrient Thresholds Needed to Control Harmful Cyanobacterial Blooms in Eutrophic Lake Taihu, China
Published in Environmental science & technology (20-01-2015)“…Nutrient overenrichment has led to dramatic increases in harmful cyanobacterial blooms, creating serious threats to drinking water supplies, ecological and…”
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6
AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control
Published in Cell metabolism (03-03-2020)“…The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are interlinked, opposing signaling pathways involved in sensing availability of…”
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7
Multiple amino acid sensing inputs to mTORC1
Published in Cell research (01-01-2016)“…The evolutionarily conserved target of rapamycin complex 1 (TORC1) is a master regulator of cell growth and metabolism. In mammals, growth factors and cellular…”
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Regulation of mTORC2 Signaling
Published in Genes (04-09-2020)“…Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and…”
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Glutaminolysis Activates Rag-mTORC1 Signaling
Published in Molecular cell (10-08-2012)“…Amino acids control cell growth via activation of the highly conserved kinase TORC1. Glutamine is a particularly important amino acid in cell growth control…”
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Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
Published in Trends in cell biology (01-05-2012)“…Many cellular processes including apoptosis, autophagy, translation, energy metabolism, and inflammation are controlled by the mammalian target of rapamycin…”
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Activation of mTORC2 by Association with the Ribosome
Published in Cell (04-03-2011)“…The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller of growth. Mammalian TOR complex 2 (mTORC2) regulates AGC kinase…”
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12
Societal acceptance of wind farms: Analysis of four common themes across Australian case studies
Published in Energy policy (01-07-2013)“…Australia's renewable energy target (RET) seeks to provide 20 per cent of Australia's electricity generation from renewable energy sources by 2020. As wind…”
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13
The Search for Antiaging Interventions: From Elixirs to Fasting Regimens
Published in Cell (19-06-2014)“…The phenomenon of aging is an intrinsic feature of life. Accordingly, the possibility to manipulate it has fascinated humans likely since time immemorial…”
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14
Rapamycin passes the torch: a new generation of mTOR inhibitors
Published in Nature reviews. Drug discovery (01-11-2011)“…Key Points TOR (target of rapamycin) is a Ser/Thr kinase that is present in all eukaryotes. It integrates various stresses and various inputs that are…”
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Systematic review: adherence to a gluten‐free diet in adult patients with coeliac disease
Published in Alimentary pharmacology & therapeutics (15-08-2009)“…Summary Background Coeliac disease is increasingly diagnosed in adult patients who present with atypical symptoms or who are asymptomatic and detected by case…”
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What is a pericyte?
Published in Journal of cerebral blood flow and metabolism (01-02-2016)“…Pericytes, spatially isolated contractile cells on capillaries, have been reported to control cerebral blood flow physiologically, and to limit blood flow…”
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Structural Equations and Causation
Published in Philosophical studies (01-01-2007)“…Structural equations have become increasingly popular in recent years as tools for understanding causation. But standard structural equations approaches to…”
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mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology
Published in Proceedings of the National Academy of Sciences - PNAS (30-07-2013)“…The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller of growth. Mammalian TOR complex 2 (mTORC2) regulates AGC kinase…”
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Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
Published in Cell metabolism (02-05-2012)“…Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC kinase family members, including Akt, SGK1, and PKC, in response to…”
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mTOR and the control of whole body metabolism
Published in Current opinion in cell biology (01-04-2009)“…Mammalian Target of Rapamycin (mTOR) is a highly conserved protein kinase that functions as part of two distinct multiprotein complexes to regulate growth and…”
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